Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7073-94-1, name is 1-Bromo-2-isopropylbenzene, A new synthetic method of this compound is introduced below., Computed Properties of C9H11Br
1-Br-2-isopropylbenzene (1.306 g, 6.561 mmol, 2.7 eq)Was added THF (13.122 mL) and t-BuLi (8.36 mL) was added at -78 C. This was reacted for 2 hours and then heated to room temperature to prepare lithium cumene. The ligand precursor prepared above N-(2,6-diisopropylphenyl)-1-(6-(2-methyl-1,2,3,4-tetrahydroquinolin-8-yl)pyridin-2-yl)methanimine(1 g, 2.43 mmol, 1 eq) was added diethyl ether (24.3 mL), and the lithium cumene was added dropwise at -78 C. The reaction was allowed to warm to room temperature overnight, quenched with 1 N NH4Cl and worked up with Ether / H2O. The water was dried with Na2SO4 and the solvent was vacuum dried with a rotary evaporator. Yellow oil, 1.48 g, was obtained in quantitative yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LG Chemical Co., Ltd.; Han, Hyo Jung; Han, Ki Won; Jang, Jae Kwon; Lee, Eun Jung; Lee, Chung Hoon; (59 pag.)KR2017/95036; (2017); A;,
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bromide – Wiktionary