Category: 70298-88-3

《Light-Driven Coordination-Induced Spin-State Switching: Rational Design of Photodissociable Ligands》 was published in Chemistry – A European Journal in 2012. These research results belong to Thies, Steffen; Sell, Hanno; Bornholdt, Claudia; Schuett, Christian; Koehler, Felix; Tuczek, Felix; Herges, Rainer. Application of 70298-88-3 The article mentions the following:

The bistability of spin states (e.g., spin crossover) in bulk materials is well investigated and understood. The authors recently extended spin-state switching to isolated mols. at room temperature (light-driven coordination-induced spin-state switching, or LD-CISSS). Whereas bistability and hysteresis in conventional spin-crossover materials are caused by cooperative effects in the crystal lattice, spin switching in LD-CISSS is achieved by reversibly changing the coordination number of a metal complex by means of a photochromic ligand that binds in one configuration but dissociates in the other form. The authors present math. proof that the maximum efficiency in property switching by such a photodissociable ligand (PDL) is only dependent on the ratio of the association constants of both configurations. Rational design by using DFT calculations was applied to develop a photoswitchable ligand with a high switching efficiency. The starting point was a nickel-porphyrin as the transition-metal complex and 3-phenylazopyridine as the photodissociable ligand. Calculations and experiments were performed in two iterative steps to find a substitution pattern at the phenylazopyridine ligand that provided optimum performance. Following this strategy, the authors synthesized an improved photodissociable ligand that binds to the Ni-porphyrin with an association constant that is 5.36 times higher in its trans form than in the cis form. The switching efficiency between the diamagnetic and paramagnetic state is efficient as well (72 % paramagnetic Ni-porphyrin after irradiation at 365 nm, 32 % paramagnetic species after irradiation at 440 nm). Potential applications arise from the fact that the LD-CISSS approach for the first time allows reversible switching of the magnetic susceptibility of a homogeneous solution Photoswitchable contrast agents for magnetic resonance imaging and light-controlled magnetic levitation are conceivable applications. In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn October 7, 1983 ,《Regiospecific electrophilic substitution of aminopyridines: ortho lithiation of 2-, 3-, and 4-(pivaloylamino)pyridines》 was published in Journal of Organic Chemistry. The article was written by Turner, James A.. The article contains the following contents:

2- And 4-(Pivaloylamino)pyridines undergo lithiation exclusively at C-3 and then react with a variety of electrophiles to produce 2,3- and 3,4-disubstituted pyridines, resp. Removal of the pivaloyl protecting group results in overall electrophilic substitution of an aminopyridine. Utilization of this method is exemplified by efficient syntheses of 2- and 4-aminonicotinaldehydes. Minor modifications of the reaction conditions permitted exclusive ortho lithiation of 2-(pivaloylamino)pyridines addnl. functionalized by chloro, fluoro, or Me groups. Although the major product from reaction of 3-(pivaloylamino)pyridine by this method was lithiation at C-4, the reaction was complicated by substantial quantities of product derived from nucleophilic attack by BuLi on the pyridine nucleus. In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Biggadike, Keith; Boudjelal, Mohamed; Clackers, Margaret; Coe, Diane M.; Demaine, Derek A.; Hardy, George W.; Humphreys, Davina; Inglis, Graham G. A.; Johnston, Michael J.; Jones, Haydn T.; House, David; Loiseau, Richard; Needham, Deborah; Skone, Philip A.; Uings, Iain; Veitch, Gemma; Weingarten, Gordon G.; McLay, Iain M.; Macdonald, Simon J. F. published their research in Journal of Medicinal Chemistry on December 27 ,2007. The article was titled 《Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity》.Reference of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide The article contains the following contents:

The synthesis and biol. activity of tetrahydronaphthalene derivatives coupled to various heterocycles, e.g. I, are described. These compounds are potent glucocorticoid receptor agonists with efficacy selectivity in an NFκB glucocorticoid receptor (GR) agonist assay (representing transrepression effects) over an MMTV GR agonist assay (representing transactivation effects). Quinolones, indoles, and C- and N-linked quinolines are some of the heterocycles that provide efficacy selectivity. For example, one enantiomer of the isoquinoline II has NFκB agonism with pIC50 of 8.66 (89%) and reduced efficacy in MMTV agonism (6%), and one enantiomer of the quinoline III has NFκB agonism with pIC50 of 9.30 (101%) and reduced efficacy in MMTV agonism with pEC50 of 8.02 (47%). A description of how a compound from each class is modeled in the active site of the receptor is given. In the experimental materials used by the author, we found 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Reference of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Reference of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Madak, Joseph T.; Cuthbertson, Christine R.; Miyata, Yoshinari; Tamura, Shuzo; Petrunak, Elyse M.; Stuckey, Jeanne A.; Han, Yanyan; He, Miao; Sun, Duxin; Showalter, Hollis D.; Neamati, Nouri published an article in Journal of Medicinal Chemistry. The title of the article was 《Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase》.Application of 70298-88-3 The author mentioned the following in the article:

We pursued a structure-guided approach toward the development of improved dihydroorotate dehydrogenase (DHODH) inhibitors with the goal of forming new interactions between DHODH and the brequinar class of inhibitors. Two potential residues, T63 and Y356, suitable for novel H-bonding interactions, were identified in the brequinar-binding pocket. Analogs were designed to maintain the essential pharmacophore and form new electrostatic interactions through strategically positioned H-bond accepting groups. This effort led to the discovery of potent quinoline-based analogs 41 (DHODH IC50 = 9.71 ± 1.4 nM) and 43 (DHODH IC50 = 26.2 ± 1.8 nM). A cocrystal structure between 43 and DHODH depicts a novel water mediated H-bond interaction with T63. Addnl. optimization led to the 1,7-naphthyridine 46 (DHODH IC50 = 28.3 ± 3.3 nM) that forms a novel H-bond with Y356. Importantly, compound 41 possesses significant oral bioavailability (F = 56%) and an elimination t1/2 = 2.78 h (PO dosing). In conclusion, the data supports further preclin. studies of our lead compounds toward selection of a candidate for early-stage clin. development. The results came from multiple reactions, including the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Martinez-Viturro, Carlos M.; Dominguez, Domingo published an article in Tetrahedron Letters. The title of the article was 《Synthesis of aza analogues of the anticancer agent batracylin》.Recommanded Product: 70298-88-3 The author mentioned the following in the article:

Three series of pyrido-fused pyrimido[2,1-a]isoindol-7-ones were prepared from readily available (aminopyridinyl)(aryl)methanones by reduction followed by a Mitsunobu reaction with phthalimide and acid-catalyzed cyclodehydration. This approach provided a wide variety of aza analogs of the antitumor agent batracylin. After reading the article, we found that the author used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Recommanded Product: 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn September 30, 1990 ,《Synthesis of 3-amino-4-phenylpyridines: a novel strategy for the preparation of CD ring models of streptonigrin》 was published in Journal of the Chemical Society. The article was written by Marsais, Francis; Rovera, Jean Claude; Turck, Alain; Godard, Alain; Queguiner, Guy. The article contains the following contents:

3-Amino-4-phenylpyridine derivatives were prepared 3-Pivaloylaminopyridines were lithiated by BuLi before reaction with iodine as electrophile to afford 4-iodo-3-pivaloylaminopyridines. Cross-coupling of the latter with suitable phenylboronic acids gives CD ring models e.g. I, of streptonigrin. In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 70298-88-3On September 10, 2009 ,《Design, Synthesis, and Structure-Activity Relationships of Aminopyridine N-Oxides, a Novel Scaffold for the Potent and Selective Inhibition of p38 Mitogen Activated Protein Kinase》 was published in Journal of Medicinal Chemistry. The article was written by Lumeras, Wenceslao; Caturla, Francisco; Vidal, Laura; Esteve, Cristina; Balague, Cristina; Orellana, Adelina; Dominguez, Maria; Roca, Ramon; Huerta, Josep M.; Godessart, Nuria; Vidal, Bernat. The article contains the following contents:

A novel series of aminopyridine N-oxides, e.g. I, were designed, synthesized, and tested for their ability to inhibit p38α MAP kinase. Some of these compounds showed a significant reduction in the LPS-induced TNFα production in human whole blood. Structure-activity relationship studies revealed that N-oxide oxygen was essential for activity and was probably a determinant factor for a marked selectivity against other related kinases. Compound I was identified as a potent and selective p38α inhibitor with an appropriate balance between potency and pharmacokinetics. In vivo efficacy of I was demonstrated in reducing TNFα levels in an acute murine model of inflammation (ED50 = 1 mg/kg in LPS-induced TNFα production when dosed orally 1.5 h prior to LPS administration). The oral efficacy of I was further demonstrated in a chronic model of adjuvant arthritis in rats with established disease when administered orally (ED50 = 4.5 mg/kg). The experimental process involved the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3SDS of cas: 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fiakpui, Charles Y.; Knaus, Edward E. published an article in Canadian Journal of Chemistry. The title of the article was 《An improved synthesis of 1,3-dihydro-1-methyl-5-phenyl-2H-pyrido[3,4-e]-1,4-diazepin-2-one via ortho-directed lithiation of 3-[(tert-butylcarbonyl)- and 3-[(tert-butoxycarbonyl)amino)pyridine]》.Formula: C10H14N2O The author mentioned the following in the article:

The ortho-directed lithiation of the title compounds I (R = CMe3, OCMe3) with alkyllithiums and benzoylation with PhCONEt2 followed by acid hydrolysis gave 63-66% 3-amino-4-benzoylpyridine (II). Amidation of R1NHCH2CO2H (R1 = PhCH2O2C, Me3CO2C) with II afforded[[(aminomethyl)carbonyl]amino]benzoylpyridines III (same R1). Acid-catalyzed hydrolysis and cyclocondensation of III, followed by methylation gave pyridodiazepinone IV in 36% overall yield from I.2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Formula: C10H14N2O) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Formula: C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《The chemistry of N-substituted benzotriazoles. Part 20. Mono-N-tert-butylation of aromatic and heteroaromatic amines》 was published in Journal of the Chemical Society in 1989. These research results belong to Katritzky, Alan R.; Vanden Eynde, Jean Jacques. Related Products of 70298-88-3 The article mentions the following:

Adducts R1CH(1-benzotriazolyl)NHR2, (R1 = Pr, CHMe2, CMe3, R2 = 2-, 3-pyridyl, Ph, 4-methyl-2-pyridyl, 5-chloro-2-pyridyl, 3-ClC6H4, 3-, 4-O2NC6H4), readily available from aldehydes, primary aromatic or heteroaromatic amines, and benzotriazole are converted by H2O2-SeO2 into mixtures of R1CONHR2 and HCONR1R2 in proportions which depend rationally on the nature of the R1 group. For R1 = CMe3, the formamide Me3CNR2CHO is formed in satisfactory yields, thus enabling the title reaction to be achieved. After reading the article, we found that the author used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Related Products of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Related Products of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 70298-88-3On October 12, 2011 ,《Light-Induced Spin Change by Photodissociable External Ligands: A New Principle for Magnetic Switching of Molecules》 was published in Journal of the American Chemical Society. The article was written by Thies, Steffen; Sell, Hanno; Schuett, Christian; Bornholdt, Claudia; Naether, Christian; Tuczek, Felix; Herges, Rainer. The article contains the following contents:

Magnetic bistability in spin-crossover materials generally is a collective phenomenon that arises from the cooperative interaction of a large number of microscopic magnetic moments within the crystal lattice in the solid state. The authors now report on individual mols. in homogeneous solution that are switched between the diamagnetic and paramagnetic states at room temperature by light-driven coordination-induced spin-state switching (LD-CISSS). Switching of the coordination number (and concurrently of the spin state) was achieved by using Ni-porphyrin as a square-planar platform and azopyridines as photodissociable axial ligands. The square-planar Ni-porphyrin is diamagnetic (low-spin, S = 0), and all complexes with axial ligands are paramagnetic (high-spin, S = 1). Association constants were determined for all conceivable 1:1 and 1:2 porphyrin/azopyridine complexes. The binding constants of the trans azopyridines are larger than those of the corresponding cis isomers. Thus, upon irradiation with UV light (365 nm, trans → cis) and visible light (455 nm, cis → trans), switching of the magnetic properties was achieved. Upon substitution of the azopyridines at the 4- and 4′-positions with larger substituents, the difference in trans and cis association constants, and thus the switching efficiency, was increased. A photoinduced, reversible switching between 20 and 68% paramagnetic Ni species in solution was achieved with iso-Pr substituents at room temperature In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Product Details of 70298-88-3) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Product Details of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics