Category: 70298-88-3

《Ortho-functionalization of aminopyridines; regioselective lithiation of 3-pivaloylaminopyridines》 was published in Synthesis in 1982. These research results belong to Gungor, T.; Marsais, F.; Queguiner, G.. Application of 70298-88-3 The article mentions the following:

3-Pivaloylaminopyridine (I) was selectively lithiated in the 4-position. Treatment of the lithio derivative with RCHO (R = Ph, 4-MeC6H4, 2-MeOC6H4, 3,4-methylenedioxyphenyl, 2-thienyl, Me) gave the alcs. II. I-4-d was also prepared The results came from multiple reactions, including the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

El-Zahraa, F.; El-Basil, S.; El-Sayed, M.; Ghoneim, K. M.; Khalifa, M. published an article on January 31 ,1979. The article was titled 《Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics》, and you may find the article in Pharmazie.HPLC of Formula: 70298-88-3 The information in the text is summarized as follows:

Eighteen Ph2CHCONHR (I; R = e.g., 2,6-, 2,5-, 2,4-, 3,4-, 3,5-Me2C6H3, 4,5-MeClC6H3, 4-O2NC6H4) and 14 Me3CCONHR1 (II; R1 = e.g., 3,6-Me2C6H3, 3-pyridyl, 4-nitro-2-pyridyl) were prepared in 45-90% yield by reaction of the acid chloride with the resp. amine. The most active intradermal anesthesia in guinea pigs was I (R = 4-methyl-5-chlorophenyl); its activity was more than double that of procaine hydrochloride. As a corneal anesthetic II (R1 = 2,6-Me2C6H3) was the most active anesthetic and for plexus anesthesia I (R = 2,6-Me2C6H3) was the most active. In the experimental materials used by the author, we found 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3HPLC of Formula: 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.HPLC of Formula: 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Pd-catalyzed oxidative C-H/C-H cross-coupling of pyridines with heteroarenes》 was published in Chemical Science in 2013. These research results belong to Liu, Bo; Huang, Yumin; Lan, Jingbo; Song, Feijie; You, Jingsong. Electric Literature of C10H14N2O The article mentions the following:

The authors have developed for the first time a general, concise and highly selective method for the C2-heteroarylation of pyridines and related azines with a broad range of heteroarenes via a two-fold C-H activation, which streamlines the previous approaches that require the activated azine N-oxide as the coupling partner. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Electric Literature of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy published their research in Perkin 1 on December 21 ,2000. The article was titled 《Reaction of magnesiated bases on substituted pyridines: deprotonation or 1,4-addition?》.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide The article contains the following contents:

N-(tert.-Butyl)pyridine-2-carboxamide, N-phenylpyridine-2-carboxamide, and 2,2-dimethyl-N-(2-pyridyl)propanamide are readily deprotonated at C-3 with a stoichiometric amount of iso-PrMgCl or Bu2Mg in THF under reflux. Subsequent trapping with various electrophiles (deuterated water, aldehydes, iodine and di-Me disulfide) gives 2,3-disubstituted pyridines carrying a useful carboxylic acid- or amino-derived function at C-2. When N-(tert.-butyl)pyridine-3-carboxamide and 2,2-dimethyl-N-(3-pyridyl)propanamide are subjected to the same reaction conditions, 1,4-addition to the pyridine ring occurs, giving 4-alkyl derivatives Starting from N-(tert-butyl)pyridine-4-carboxamide, 1,2-addition and deprotonation reactions occur simultaneously. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rocca, Patrick; Marsais, Francis; Godard, Alain; Queguiner, Guy published an article in Tetrahedron. The title of the article was 《Connection between metalation and cross-coupling strategies. A new convergent route to azacarbazoles》.Computed Properties of C10H14N2O The author mentioned the following in the article:

New convergent synthesis of azacarbazoles through metalation, cross-coupling reaction, and intramol. substitution via (2-aminobenzene)boronic acid and ortho-fluoroiodopyridines are presented. Thus, 2-(HO)2BC6H4NHCOCMe3 coupled with pyridines I (X = F, Cl, Y = iodo, Z = H; X = H, Y = F, Z = iodo; X = H, Y = iodo, Z = F; X = iodo, Y = F, Z = H) to give the corresponding (pyridylphenyl)propanamides II (R = F, Cl). The 3-fluoro-4-pyridyl derivative of II was treated with pyridinium chloride under reflux to give β-carboline III. The α-, γ-, and δ-carbolines were prepared similarly. In the experiment, the researchers used many compounds, for example, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Computed Properties of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Computed Properties of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn May 2, 2009 ,《Formation of new 4-isocyanobut-2-enenitriles by thermal ring cleavage of 3-pyridyl azides》 appeared in Tetrahedron. The author of the article were Stockmann, Vegar; Bakke, Jan M.; Bruheim, Per; Fiksdahl, Anne. The article conveys some information:

A new thermal ring cleavage of 3-pyridyl nitrenes for the formation of 4-isocyanobut-2-enenitrile products is reported. Thermolysis of 4-(thien-3-yl)-3-pyridyl azide and 3-azido-4-(1-TIPS-1H-pyrrol-3-yl)pyridine afforded two new isonitrile-nitrile products by ring cleavage; 4-isocyano-2-(thiophen-3-yl)but-2-enenitrile (I, 27%) and 4-isocyano-2-(1-TIPS-1H-pyrrol-3-yl)but-2-enenitrile (II, 20%), in addition to the previously reported pyrido[3,4-b]thienopyrrole (29%) and pyrido[3,4-b]pyrrolo[3,2-d]pyrrole (71%) products. Minor amounts of 2-(thien-3-yl)-1H-pyrrole-3-carbonitrile (III, 6%), formed by ring contraction, were also isolated after thermolysis of 4-(thien-3-yl)-3-pyridyl azide. Isonitriles I and II underwent degradation into amine and formamide, resp., by acidic hydrolysis. The nature and chem. of compounds I, III and II were investigated.2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C10H14N2OOn March 15, 2011, Metro, Thomas-Xavier; Fayet, Christine; Arnaud, Florian; Rameix, Nathalie; Fraisse, Pierre; Janody, Simon; Sevrin, Mireille; George, Pascal; Vogel, Rachel published an article in Synlett. The article was 《Synthesis of 2,2-disubstituted azaindolines by intramolecular cyclization in acidic media》. The article mentions the following:

The synthesis of a diverse array of 2,2-disubstituted azaindolines, e.g. I, is reported. The bicyclic core is built by a simple acidic treatment of conveniently substituted aminopyridines. The results came from multiple reactions, including the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Synthetic Route of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stockmann, Vegar; Fiksdahl, Anne published their research in Tetrahedron on August 4 ,2008. The article was titled 《Preparation of new pyrido[3,4-b]thienopyrroles and pyrido[4,3-e]thienopyridazines》.Category: amides-buliding-blocks The article contains the following contents:

Two new types of pyrido-fused tris-heterocycles (1a,b and 2a,b) were prepared from 3-aminopyridine in five/six steps. A synthetic strategy for the preparation of the novel pyrido[3,4-b]thieno[2,3- and 3,2-d]pyrroles (1a,b) and pyrido[4,3-e]thieno[2,3- and 3,2-c]pyridazines (2a,b) was studied. The Suzuki cross coupling of the appropriate 2- and 3-thienoboronic acids (3,4) and 4-bromo-3-pyridylpivaloylamide (9) afforded the biaryl coupling products (10,11) in high yields (85%). Diazotization of the hydrolyzed (2-thienyl)-coupling product (12) and azide substitution gave the 3-azido-4-(2-thienyl)pyridine intermediate (72%, 14). 3-Azido-4-(3-thienyl)pyridine (15) was prepared by exchanging the previous order of reactions. The desired β-carboline thiophene analogs (1a,b) were obtained via the nitrene by thermal decomposition of the azido precursors (14,15). By optimizing conditions for intramol. diazocoupling, the corresponding pyridazine products (72-83%, 2a,b) were afforded. After reading the article, we found that the author used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Category: amides-buliding-blocks)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocksOn September 16, 2016 ,《Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids》 was published in Organic Letters. The article was written by Zhu, Yan-Ping; Sergeyev, Sergey; Franck, Philippe; Orru, Romano V. A.; Maes, Bert U. W.. The article contains the following contents:

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with com. reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols. In the experimental materials used by the author, we found 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Category: amides-buliding-blocks)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nguyen, Trang T.; Hull, Kami L. published their research in ACS Catalysis on December 2 ,2016. The article was titled 《Rhodium-Catalyzed Oxidative Amidation of Sterically Hindered Aldehydes and Alcohols》.Related Products of 70298-88-3 The article contains the following contents:

In the presence of Rh(cod)2BF4, either 1,4-bis(diphenylphosphino)butane, tricyclohexylphosphine, or Xantphos, and either styrene, Me methacrylate, or α,α,α-trifluoroacetophenone with cesium acetate in THF, pivaldehyde or β,β-disubstituted alcs. underwent oxidative amidation with aliphatic and aromatic amines to yield hindered α,α-disubstituted amides in 25-94% yields. Mechanistic studies were performed to gain insight into the catalytic cycles for aldehyde and alc. amidation. The results came from multiple reactions, including the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Related Products of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics