Category: 70-55-3

Artigas, Albert; Castanyer, Cristina; Roig, Nil; Lledo, Agusti; Sola, Miquel; Pla-Quintana, Anna; Roglans, Anna published an article in 2021. The article was titled 《Synthesis of Fused Dihydroazepine Derivatives of Fullerenes by a Rh-Catalyzed Cascade Process》, and you may find the article in Advanced Synthesis & Catalysis.Recommanded Product: 70-55-3 The information in the text is summarized as follows:

A synthetic methodol. was reported that functionalizes C60 and C70 fullerenes with dihydroazepine rings by a cascade reaction encompassing a rhodium-catalyzed cycloisomerization of 1,5-bisallenes and a [4+2] cycloaddition This transition metal-catalyzed cascade reaction provided a versatile and step-economical approach to the synthesis of 6,7-membered polyheterocyclic fullerene adducts. Electrochem. characterization of the products obtained ventures their application in organic and perovskite photovoltaic devices.4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C7H9NO2SIn 2022 ,《Solvent-Triggered Long-Range Proton Transport in 7-Hydroxyquinoline Using a Sulfonamide Transporter Group》 was published in Journal of Organic Chemistry. The article was written by Nakashima, Kosuke; Georgiev, Anton; Yordanov, Dancho; Matsushima, Yasuyuki; Hirashima, Shin-ichi; Miura, Tsuyoshi; Antonov, Liudmil. The article contains the following contents:

The ability of long-range proton transport by substitution of 7-hydroxyquinoline at the eighth position with sulfonamide and sulfonylhydrazone rotor units to act as a crane-arm has been studied. Different proton transport pathways triggered by different stimuli have been established depending on the structure of the crane-arms. Solvent-driven proton switching from OH to the quinoline nitrogen (Nquin) site, facilitated by a sulfonamide transporter group in polar protic and aprotic solvents, has been confirmed by optical (absorption and fluorescence) and NMR spectroscopies as well as by single-crystal X-ray structure anal. Photoinduced long-range proton transport to the Nquin site upon 340 nm UV light irradiation has been estimated in sulfonylhydrazone, which is not sensitive to solvent-driven switching. Both compounds have exhibited acid-triggered switching by trifluoroacetic acid due to the formation of a stable six-membered intramol. hydrogen bonding interaction between the protonated Nquin and crane-arm. The structures of acid-switched form were confirmed by NMR spectroscopy and single-crystal X-ray structure anal. The behavior of the compounds suggests a big step forward in the advanced proton pump-switching architecture because they cover three distinct driving forces in the switching process: solvent, light, and acid. The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Separation Science plus included an article by Hidalgo-Serrano, Miriam; Borrull, Francesc; Marce, Rosa M.; Pocurull, Eva. Electric Literature of C7H9NO2S. The article was titled 《Presence of benzotriazoles, benzothiazoles and benzenesulfonamides in surface water samples by liquid chromatography coupled to high-resolution mass spectrometry》. The information in the text is summarized as follows:

An anal. method has been developed for the simultaneous determination of seven benzotriazole, five benzothiazole and four benzenesulfonamide derivatives in surface water samples. The procedure is based on solid-phase extraction with Oasis HLB, followed by high-performance liquid chromatog. coupled to high-resolution mass spectrometry. Apparent recoveries ranged from 40 to 101%, except for compounds the matrix effect of which was above -60%. The repeatability (n = 5) of the method was below 20% for all compounds except 4-hydroxybenzotriazole in river water. The method limits of detection for most compounds ranged from 1 to 12 ng/L for both river water and seawater. The method was then used for the determination of the studied compounds in several river water and seawater samples from harbor and coastal areas. 1-H-Benzotriazole (up to 78 ng/L in river water and above the upper limit of the calibration curve in seawater) and 4-methyl-1-H-benzotriazole (up to 44 ng/L in river water and 338 ng/L in seawater) were the most abundant compounds quantified in the samples, even though 5-methyl-1-H-benzotriazole and 2-hydroxybenzothiazole were also found in most samples. Some compounds were frequently found in certain types of samples, such as 2-aminobenzothiazole in river water. Benzenesulfonamide derivatives could not be quantified in any sample. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Boron-Catalyzed N-Alkylation of Arylamines and Arylamides with Benzylic Alcohols》 was published in Journal of Organic Chemistry in 2020. These research results belong to Guru, Murali Mohan; Thorve, Pradip Ramdas; Maji, Biplab. Name: 4-Methylbenzenesulfonamide The article mentions the following:

A sustainable boron-based catalytic approach for chemoselective N-alkylation of primary and secondary aromatic amines and amides with primary, secondary, and tertiary benzylic alcs. have been presented. The metal-free protocol operates at low catalyst loading, tolerates several functional groups and generates H2O as the sole byproduct. Preliminary mechanistic studies were performed to demonstrate the crucial role of boron catalyst for the activation of the intermediate dibenzyl ether and to identify the rate-determining step. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Name: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocksIn 2022 ,《Synthesis, characterization, molecular modeling against EGFR target and ADME/T analysis of novel purine derivatives of sulfonamides》 appeared in Journal of Molecular Structure. The author of the article were Bhat, Mashooq A.; Tuzun, Burak; Alsaif, Nawaf A.; Ali Khan, Azmat; Naglah, Ahmed M.. The article conveys some information:

A novel series of purine derivatives containing sulfonamide moiety I [R = NH, CH2CH2NH, NHSO2, etc.; R1 = SO2OH, SO2NH2, SO2NC(NH)2, etc.] were synthesized in good yield by the single-step reaction method. The chem. activities of the mols. at the B3LYP, HF, M062X level 3-21 g, 6-31 g, and SDD basis were set with the Gaussian package program. The biol. activities of the mols. against the epidermal growth factor receptor (EGFR) proteins (PDB ID: 1M17 and 2ITN) were compared with the Maestro Mol. modeling platform by Schrodinger. Compound I [R = NH; R1 = SO2NH-2-4,5-dimethyloxazole] had the highest value in all basis sets, according to the numerical value of the HOMO parameter. The interactions of compound I [R = NH; R1 = SO2NH-2-4,5-dimethyloxazole] with Epidermal Growth Factor Receptor ID: 1M17 and ID: 2ITN proteins, presented the highest activity. Finally, ADME/T anal. was performed to examine the drug properties of the mols. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Category: amides-buliding-blocks)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 70-55-3In 2021 ,《Rhodium(III)-Catalyzed Aryl Borrowing Amination of Diaryl Methanols Containing Pyridine-Directing Groups》 appeared in Advanced Synthesis & Catalysis. The author of the article were Liu, Zheng-Qiang; Tao, Jing; Zhuang, Xin; Hong, Chuan-Ming; Luo, Zhen; Wu, Yu-Fei; Li, Qing-Hua; Liu, Tang-Lin. The article conveys some information:

The rhodium(III)-catalyzed aryl borrowing amination of various diaryl methanols with sulfonamides was developed. The amination of alcs. via C-C bond activation was less developed and remains a challenge. These aryl borrowing reactions feature mild reaction conditions, good functional group tolerance and compatibility with a wide range of alcs., overall comprising an atom- and step-economic procedure. Mechanistic studies indicated that a rhodacycle complex exist during the aryl borrowing amination reaction. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Asian Journal of Organic Chemistry included an article by Paul, Dipankar; Borah, Apurba; Khatua, Snehadrinarayan; Nath Chatterjee, Paresh. Computed Properties of C7H9NO2S. The article was titled 《para-Toluenesulfonic Acid-Catalyzed, Ultrasound-Promoted, One-Pot, Three-Component Coupling of Aldehydes, -Dicarbonyls/Amides and Electron-Rich Arenes》. The information in the text is summarized as follows:

An ultrasound-promoted, metal-free method for the three-component coupling of aldehydes, β-dicarbonyls/amides and electron-rich arenes was reported. The versatility of the method was established by employing varieties of functionally diverse components for coupling. In lieu of expensive, toxic or specifically designed catalysts, the method presented employed com. available, inexpensive and non-toxic para-toluenesulfonic acid monohydrate (pTSA) as an efficient catalyst. An insight into the mechanistic pathway of the three-component coupling reaction was also provided by isolating the intermediate and subsequently converting it to the final product. The flexibility of choosing the components in the method described allowed one-pot access to a variety of relevant organic motifs. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Discovery and characterization of an acridine radical photoreductant》 was written by MacKenzie, Ian A.; Wang, Leifeng; Onuska, Nicholas P. R.; Williams, Olivia F.; Begam, Khadiza; Moran, Andrew M.; Dunietz, Barry D.; Nicewicz, David A.. Formula: C7H9NO2S And the article was included in Nature (London, United Kingdom) in 2020. The article conveys some information:

Photoinduced electron transfer (PET) is a phenomenon whereby the absorption of light by a chem. species provides an energetic driving force for an electron-transfer reaction1-4. This mechanism is relevant in many areas of chem., including the study of natural and artificial photosynthesis, photovoltaics and photosensitive materials. In recent years, research in the area of photoredox catalysis has enabled the use of PET for the catalytic generation of both neutral and charged organic free-radical species. These technologies have enabled previously inaccessible chem. transformations and have been widely used in both academic and industrial settings. Such reactions are often catalyzed by visible-light-absorbing organic mols. or transition-metal complexes of ruthenium, iridium, chromium or copper5,6. Although various closed-shell organic mols. have been shown to behave as competent electron-transfer catalysts in photoredox reactions, there are only limited reports of PET reactions involving neutral organic radicals as excited-state donors or acceptors. This is unsurprising because the lifetimes of doublet excited states of neutral organic radicals are typically several orders of magnitude shorter than the singlet lifetimes of known transition-metal photoredox catalysts7-11. Here we document the discovery, characterization and reactivity of a neutral acridine radical with a maximum excited-state oxidation potential of -3.36 V vs. a SCE, which is similarly reducing to elemental lithium, making this radical one of the most potent chem. reductants reported12. Spectroscopic, computational and chem. studies indicate that the formation of a twisted intramol. charge-transfer species enables the population of higher-energy doublet excited states, leading to the observed potent photoreducing behavior. We demonstrate that this catalytically generated PET catalyst facilitates several chem. reactions that typically require alkali metal reductants and can be used in other organic transformations that require dissolving metal reductants. After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hopkins, Megan D.; Ozmer, Garett L.; Witt, Ryan C.; Brandeburg, Zachary C.; Rogers, David A.; Keating, Claire E.; Petcoff, Presley L.; Sheaff, Robert J.; Lamar, Angus A. published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《PhI(OAc)2 and iodine-mediated synthesis of N-alkyl sulfonamides derived from polycyclic aromatic hydrocarbon scaffolds and determination of their antibacterial and cytotoxic activities》.Reference of 4-Methylbenzenesulfonamide The article contains the following contents:

The development of new approaches toward chemo- and regioselective functionalization of polycyclic aromatic hydrocarbon (PAH) scaffolds will provide opportunities for the synthesis of novel biol. active small mols. that exploit the high degree of lipophilicity imparted by the PAH unit. Herein, new synthetic method for C-X bond substitution that is speculated to operate via a N-centered radical (NCR) mechanism according to exptl. observations was reported. A series of PAH sulfonamides have been synthesized and their biol. activity has been evaluated against Gram-neg. and Gram-pos. bacterial strains (using a BacTiter-Glo assay) along with a series of mammalian cell lines (using CellTiter-Blue and CellTiter-Glo assays). The viability assays have resulted in the discovery of a number of bactericidal compounds that exhibit potency similar to other well-known antibacterials such as kanamycin and tetracycline, along with the discovery of a luciferase inhibitor. Addnl., the physicochem. and drug-likeness properties of the compounds were determined exptl. and using in silico approaches and the results are presented and discussed within. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis and identification of heteroaromatic N-benzyl sulfonamides as potential anticancer agents》 were Hopkins, Megan D.; Abebe, Felagot A.; Scott, Kristina A.; Ozmer, Garett L.; Sheir, Alec A.; Schroeder, Lucas J.; Sheaff, Robert J.; Lamar, Angus A.. And the article was published in Organic & Biomolecular Chemistry in 2019. Related Products of 70-55-3 The author mentioned the following in the article:

A new approach for regioselective incorporation of a sulfonamide unit to heteroarene scaffolds has been developed and is reported within. As a result, a variety of primary benzylic N-alkylsulfonamides have been prepared via a two-step (one pot) formation from the in situ reduction of an intermediate N-sulfonyl imine under mild, practical conditions. The compounds have been screened against a variety of cell lines for cytotoxicity effects using a Cell Titer Blue assay. The cell viability investigation identifies a subset of N-benzylic sulfonamides derived from the indole scaffold to be targeted for further development into novel mols. with potential therapeutic value. The most cytotoxic of the compounds prepared, I (R1 = Me, R2,R3 = H; R4 = 4-ClC6H4), exhibited higher potency than other well-known anticancer agents Indisulam and ABT-751. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics