Category: 70-55-3

Mohammadi, Susan; Mohammadi, Somayeh; Salimi, Abdollah; Ahmadi, Rezgar published an article in 2022. The article was titled 《A Chelation-enhanced Fluorescence Assay using Thiourea Capped Carbonaceous Fluorescent Nanoparticles for As (III) Detection in Water Samples》, and you may find the article in Journal of Fluorescence.Safety of 4-Methylbenzenesulfonamide The information in the text is summarized as follows:

Herein, we designed a sensitive and selective “”Turn-On”” fluorescence nanosensor using water-soluble carbonaceous fluorescent nanomaterials (CFNs) functionalized with thiourea (CFNs-Thiourea) for efficient detection of trace concentrations of arsenic (III) in aqueous samples. The CFNs and CFNs-Thiourea were characterized by transmission electron microscopy (TEM), UV-visible spectroscopy (UV-vis) and fourier transformed IR spectroscopy (FTIR). The emission peak intensity of proposed nanosensor at 425 nm was gradually enhanced on arsenite addition in a wide detection range (3.3-828.5μg L-1) attributed to the binding of arsenite species with sulfur groups of CFNs-Thiourea. The limit of detection (LOD) was 0.48μg L-1 being much lower than the World Health Organization (WHO) recommended threshold value of 10μg L-1. Furthermore, the as-prepared CFNs-Thiourea exhibited a superb selectivity for As (III) compared to various cations and anions, such as; NO3-, NO2-, F-, Ni2+, Fe3+, Cu2+, Ca2+, Mg2+, Zn2+, Fe2+, Hg2+, Pb2+, F-, Cl-, Mn2+, Cr3+, Co2+, Cd2+, Bi3+, Al3+ and As (V) at 100 folds concentration of As (III). The turn on fluorescence nanosensor was successfully exploited for quantification of arsenic in spiked water samples with acceptable efficiencies. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Safety of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C7H9NO2SIn 2020 ,《N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal-Ligand Bifunctional Dinuclear Iridium Catalyst》 was published in Journal of Organic Chemistry. The article was written by Meng, Chong; Liu, Peng; Nguyen, Thanh Tung; Han, Xingyou; Li, Feng. The article contains the following contents:

The N-methylation of amines with methanol in aqueous solution was proposed and accomplished by using a water-soluble metal-ligand bifunctional dinuclear iridium catalyst. In the presence of [(Cp*IrCl)2(thbpym)][Cl]2 (1 mol%), a range of desirable products were obtained in high yields under environmentally benign conditions. Notably, this research exhibited the potential of transition metal-catalyzed the activation of methanol as a C1 source for the construction of C-N bond in aqueous solution The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hu, Xiao-Qiang; Hou, Ye-Xing; Liu, Zi-Kui; Gao, Yang published an article in 2021. The article was titled 《Ruthenium-catalyzed C-H/C-N bond activation: facile access to isoindolinones》, and you may find the article in Organic Chemistry Frontiers.Name: 4-Methylbenzenesulfonamide The information in the text is summarized as follows:

A facile ruthenium-catalyzed C-H/C-N bond activation and the subsequent annulation of readily available benzoic acids with in situ generated formaldimines was reported. The choice of solvent and base was critical for this reaction. This protocol allowed the efficient synthesis of a wide range of biol. important isoindolinones I [R = Ts, 4-ClC6H4SO2, 4-t-BuC6H4SO2, 4-F3COC6H4SO2; R1 = H, Me, Ph, etc.; R2 = H, Br, OPh, etc.; R3 = H, n-Bu, Cl, etc.; R4 = H, Cl, Br; R1R2 = (CH2)4; R2R3 = CH=CH-CH=CH] in useful to excellent yields without the use of any external oxidants. The late-stage modification of bioactive acids such as adapalene, bexarotene and flufenamic acid demonstrated the synthetic utility of this methodol. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Engaging Sulfonamides: Intramolecular Cross-Electrophile Coupling Reaction of Sulfonamides with Alkyl Chlorides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Lucas, Erika L.; Hewitt, Kirsten A.; Chen, Pan-Pan; Castro, Anthony J.; Hong, Xin; Jarvo, Elizabeth R.. Recommanded Product: 4-Methylbenzenesulfonamide The article mentions the following:

The application of amine derivatives as coupling partners is rare due to the inherent strength of the C-N bond. Herein, the first cross-electrophile coupling reaction of unstrained benzylic sulfonamides is repoted. Nickel-catalyzed intramol. cross-electrophile coupling reactions of acyclic and cyclic benzylic sulfonamides with pendant alkyl chlorides generate cyclopropane products. Mechanistic experiments and DFT calculations are consistent with initiation of the reaction by magnesium iodide accelerated oxidative addition of the benzylic sulfonamide. This work establishes neutral and unstrained amine derivatives as XEC partners, furnishes structural rearrangement of benzylic sulfonamides, and provides valuable information regarding catalyst design for the development of new cross-electrophile coupling reactions of carbon-heteroatom bonds. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70-55-3In 2019 ,《Multicomponent Aromatic and Benzylic Mannich Reactions through C-H Bond Activation》 was published in Chemistry – A European Journal. The article was written by Xavier, Tania; Rayapin, Corinne; Le Gall, Erwan; Presset, Marc. The article contains the following contents:

The straightforward generation of densely substituted-amines I [R = H, Me; R1 = Me, 4-MeC6H4, 2-thienyl; R2 = Ph, 4-MeC6H4, 2-thienyl, etc.; R3 = H, 3-Me, 4-OMe, etc.] was described via multicomponent Mannich reaction of sulfonamides, acetals and arylpyridines through C-H bond activation in good yields. The reaction involved a reaction between two transient species: an organometallic species, generated by transition-metal-catalyzed sp2 or sp3 C-H bond activation and an in situ generated imine. The use of an acetal as an aldehyde surrogate was found essential for the reaction to proceed. The process could be successfully applied to RhIII-catalyzed sp2 C-H bond functionalization and extended to CuII-catalyzed sp3 C-H bond functionalization. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《A three component protocol for the synthesis of aziridines using BF3·(OEt)2》 was written by Basha, Shaik Firoj; Anwar, Shaik. Safety of 4-Methylbenzenesulfonamide And the article was included in Asian Journal of Chemistry in 2020. The article conveys some information:

Synthesis of syn and anti isomers of sulfonamides derivatives I [R = H, 4-F, 4-Cl, etc.; R1 = H, 4-Cl] was carried out by a three component reaction using phenacyl bromide, p-toluenesulfonamide and benzaldehydes in presence of mild Lewis acid such as BF3·(OEt)2 in dichloromethane. The synthetic utility of this protocol was carried out with syn-isomer to yield corresponding cis-aziridines. This protocol was operationally simple for a wide variety of substituted benzaldehydes and substituted phenacyl bromides. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Safety of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70-55-3In 2019 ,《Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide》 appeared in Journal of Organic Chemistry. The author of the article were Mahato, Sachinta; Santra, Sougata; Zyryanov, Grigory V.; Majee, Adinath. The article conveys some information:

A novel and efficient approach has been developed to synthesize α-sulfonylamino ketones, e.g., PhCOCH2NHTs, through the reaction between terminal alkynes and sulfonamides under ambient air using diacetoxy iodobenzene. A library of α-sulfonylamino ketone derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and room temperature reaction conditions under ambient air and is operationally simple. A gram-scale synthesis demonstrates the potential applications of the present method. In addition, we have also synthesized α-acetoxy ketones, e.g., PhCOCH2OAc, in the absence of sulfonamide. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《An insight into the synergistic and mechanistic aspects of (IrCl3 + PdCl2) bimetallic and IrCl3, PdCl2 individual catalysts on oxidation-kinetics of kojic acid with alkaline chloramine-T》 were Radhakrishnan, Ramya; Puttaswamy. And the article was published in Chemical Data Collections in 2019. Related Products of 70-55-3 The author mentioned the following in the article:

The kinetics of (IrCl3+PdCl2) bimetallic catalytic mixture as well as individual IrCl3 and PdCl2 catalyzed and uncatalyzed oxidation of kojic acid by sodium-N-chloro-p-toluenesulfonamide (chloramine-T or CAT) in the presence of NaOH has been explored at 298 K. Under identical exptl. conditions, the kinetics for the catalyzed and uncatalyzed reactions was found to unveil varied orders. The rates of catalyzed reactions were found to be 9-38 folds faster than the uncatalyzed reaction. The observed rates of catalyzed reactions called for the existence of synergistic effect in an equimolar mixture of IrCl3+PdCl2. Justifications for the observed results have been provided by plausible mechanisms. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Chemistry – A European Journal included an article by Moore, Lucas C.; Lo, Anna; Fell, Jason S.; Duong, Matthew R.; Moreno, Jose A.; Rich, Barry E.; Bravo, Martin; Fettinger, James C.; Souza, Lucas W.; Olmstead, Marilyn M.; Houk, Kendall N.; Shaw, Jared T.. Name: 4-Methylbenzenesulfonamide. The article was titled 《Acyclic Stereocontrol in the Additions of Nucleophilic Alkenes to α-Chiral N-Sulfonyl Imines》. The information in the text is summarized as follows:

Diastereoselective Lewis acid-mediated additions of nucleophilic alkenes R(R1)C=CH2 (R = H, Me, OTMS; R1 = Ph, CH2BF3K, CH2TMS) to N-sulfonyl imines (S,E)-R2CH(OR3)CH=NTs (R2 = Me, Ph, Bn; R3 = Me, Bn, TBDPS) are reported. The canonical polar Felkin-Anh model describing additions to carbonyls does not adequately describe analogous additions to N-sulfonyl imines. The development of conditions to produce both syn and anti products syn-R2CH(OR3)CH(NTs)CH2R4 [R4 = CH=CH2, C(O)Ph, CH2=CMe] with high diastereoselectivity and good yields has been described. A stereoelectronic model consistent with exptl. outcomes is also proposed. After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis and Antimicrobial and Antioxidant Activities of Sulfonamide Derivatives Containing Tetrazole and Oxadiazole Rings》 were Ozkan, Hamdi; Demirci, Bayram. And the article was published in Journal of Heterocyclic Chemistry in 2019. Recommanded Product: 4-Methylbenzenesulfonamide The author mentioned the following in the article:

A new sulfonamide derivative with 1,3,4-oxadiazole moiety and tetrazole ring. I [R = 4-FC6H4S(O)2NH, 4-H3CC6H4S(O)2NH, (4-sulfamoylphenyl)aminyl, etc.] have been synthesized. The biol. activities of resulting compound were also investigated and observed that the compounds reveal strong antimicrobial activity over some important bacterial strains including Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and Staphylococcus aureus ATCC 29213. The in vitro antifungal properties of synthesized compounds I, II and III [R1 = H, 2,2-dimethyl-2-((1-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methyl]-1H-1,2,3,4-tetrazol-5-yl)carbamoyl)ethyl] were also a target using Candida albicans NRRL Y-477 and Saccharomyces cerevisiae fungal strains. A useful guideline for future studies about the effect of the chem. structures of sulfonamide compounds on the biol. activities have been provided. Among the target compounds, I (R = 4-FC6H4S(O)2NH, 4-ClC6H4S(O)2NH, 4-BrC6H4S(O)2NH, 4-IC6H4S(O)2NH) demonstrated surprisingly high antimicrobial activities than did others. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics