Category: 70-55-3

In 2022,Jaskolski, Mariusz; Wlodawer, Alexander; Dauter, Zbigniew; Minor, Wladek; Rupp, Bernhard published an article in Protein Science. The title of the article was 《Group depositions to the Protein Data Bank need adequate presentation and different archiving protocol》.Electric Literature of C7H9NO2S The author mentioned the following in the article:

A polemic in response to Berman H et al is given. Accurate exptl. determined structure models of biol. macromols. are used by a large and diverse community of researchers. It is an established practice to base the assessment of the structure model quality on both, expectations of correct stereochem. and, most importantly, on examination of the model’s fit to the primary exptl. evidence. In the case of Xray crystallog., the primary evidence is provided by the electron d. map. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70-55-3In 2019 ,《A Practical Method for the Preparation of Sulfonyl Chlorides and Sulfonamides from Thiols using H2O2-TAPC Reagent System》 was published in ChemistrySelect. The article was written by Parnian, Rouhallah; Soleimani, Ebrahim; Bahrami, Kiumars. The article contains the following contents:

H2O2 in the presence of TAPC (1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-chloride) as an effective and chemoselective reagent system was described for the direct conversion of thiols to sulfonyl chlorides. Upon reaction with amines, the desired sulfonamides were produced in excellent yields and in short reaction times. Mild conditions, metal-free process, and excellent selectivity are some of the advantages of this method. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Application of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Maloney, T. Parker; Dohoda, Alexander F.; Zhu, Alec C.; Michael, Forrest E. published an article in 2022. The article was titled 《Stereoretentive and regioselective selenium-catalyzed intermolecular propargylic C-H amination of alkynes》, and you may find the article in Chemical Science.Formula: C7H9NO2S The information in the text is summarized as follows:

Herein, an intermol. propargylic C-H amination of alkynes was reported. This reaction was operationally convenient and required no transition metal catalysts or additives. Terminal, silyl, and internal alkynes bearing a wide range of functional groups can be aminated in high yields. The regioselectivity of amination for unsym. internal alkynes was strongly influenced by substitution pattern (tertiary > secondary > primary) and by relatively remote heteroat. substituents. The amination of alkynes bearing α-stereocenters occurring with retention of configuration at the newly-formed C-N bond was demonstrated. Competition experiments between alkynes, kinetic isotope effects, and DFT calculations were performed to confirm the mechanistic hypothesis that initial ene reaction of a selenium bis(imide) species is the rate- and product-determining step. This ene reaction has a transition state that results in substantial partial pos. charge development at the carbon atom closer to the amination position. Inductive and/or hyperconjugative stabilization or destabilization of this pos. charge explains the observed regioselectivities. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Current Organic Synthesis included an article by Zou, Yang; Fei, Jingyi; Chen, Liangzhe; Dong, Qingfeng; Li, Houbin. Electric Literature of C7H9NO2S. The article was titled 《Application of Response Surface Methodology for Improving the Yield of 1,5-bis(ptoluenesulfonyl)- 3,7-Dihydroxyoctahydro-1,5-Diazocine》. The information in the text is summarized as follows:

Background: 3,3,7,7-tetrakis (difluoramino) octahydro-1,5-dinitro-1,5-diazocine (HNFX), as an important oxidizer in propellants, has received much attention due to its high d. and energy. However, there are many difficulties that need to be solved, such as complex synthetic processes, low product yield, high cost of raw materials and complicated purification In the synthesis of HNFX, the intermediate named 1,5-bis (p-toluenesulfonyl)-3,7-dihydroxyoctahydro-1, 5-diazocine (gem-diol), is difficult to synthesize. Methods: A simple method was used to synthesize the gem-diol. This prepared gem-diol was characterized by FT-IR, 1H NMR, m.p. and mass spectrometry. In order to increase the yield of gem-diol, response surface methodol. (RSM) was introduced to optimize exptl. conditions. Results: After the establishment of the model, the optimal conditions of synthesis were found to be 9.33h for reaction time, 6.13wt. % for the concentration of NaOH and 1.38:1 for ratio of ECH (p-toluenesulfonamide): TCA (epichlorohydrin). Under the optimal conditions, the exptl. value and the predicted value of yield were 22.18% and 22.92%, resp. Conclusion: 1,5-bis (p-toluenesulfonyl)-3,7-dihydroxyoctahydro-1,5-diazocine (gem-diol) can be synthesized using the low cost of chem. materials, including p-toluenesulfonamide, epichlorohydrin, sodium hydroxide and ethanol. Response surface methodol. (RSM) is an effective method to optimize the synthesis process, thereby improving the yield of gem-diol. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Organic Chemistry Frontiers included an article by Qi, Jifeng; Tang, Haibin; Chen, Changwei; Cui, Sunliang; Xu, Gang. Computed Properties of C7H9NO2S. The article was titled 《Reductive coupling of alkenes with unsaturated imines via a radical pathway》. The information in the text is summarized as follows:

The reductive coupling of unsaturated imines with alkenes via a radical pathway was reported. Various unsaturated imines and alkenes delivered structurally diversified benzofurans, benzothiophenes and medium-sized benzofuran-fused heterocycles. The protocol features mild reaction conditions and broad substrate scope. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Iodoamination of Alkenyl Sulfonamides by Potassium Iodide and Hydrogen Peroxide in Aqueous Medium》 were Giofre, Sabrina; Sala, Roberto; Beccalli, Egle Maria; Presti, Leonardo Lo; Broggini, Gianluigi. And the article was published in Helvetica Chimica Acta in 2019. Electric Literature of C7H9NO2S The author mentioned the following in the article:

A procedure for the iodoamination of unfunctionalized olefins tethered to a tosyl-protected NH-group has been developed. The combined use of KI and H2O2 in aqueous medium was effective for the preparation of iodomethyl-substituted nitrogen-containing heterocycles. The selective exo-trig iodocyclization provided 1,2-bifunctional 5-, 6-, and 7-membered cyclic skeletons. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 70-55-3In 2020 ,《Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines》 was published in Journal of Organic Chemistry. The article was written by Gou, Quan; Liu, Zining; Cao, Tuanwu; Tan, Xiaoping; Shi, Wenbing; Ran, Man; Cheng, Feixiang; Qin, Jun. The article contains the following contents:

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Russian Chemical Bulletin included an article by Krylov, E. N.; Virzum, L. V.. Quality Control of 4-Methylbenzenesulfonamide. The article was titled 《Acidity of arylsulfonamides as function of quantum chemical parameters of sulfonamide nitrogen》. The information in the text is summarized as follows:

The structures of aromatic sulfonamide mols. XPhSO2NH2 (X = H, 4-Me, 4-F, 4-Cl, 4-Br, 4-MeO, 4-OH, 4-NH2, 4-CN, 3-NO2, 4-NO2, 3,5-(NO2)2, 3,4-Cl2, 3-Cl-4-Me, 3,4-Me2, 3-Me-4-F, 2-Me) were calculated at the M06/6-311++G** (SMD) level of theory. The at. electrostatic potentials (AEP) and the Hirshfeld charges of the sulfonamide nitrogen atoms were determined Correlation equations relating the AEP to Bronsted acidities (pKa) of these compounds were obtained using published data and the previously unknown pKa values for a number of arylsulfonamides were calculated These pKa values are consistent with independently determined free energies of acid dissociation of sulfonamides. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Investigation of kinetics and mechanistic studies of N-(2-hydroxyethyl)phthalimide by +1 halogen oxidant in acidic medium》 was written by Latha, Vijaya; Sukhdev, Anu; Manjunath, A. S.; Puttaswamy; Deepthi, P. R.; Kumar, P. Mohan. Recommanded Product: 4-Methylbenzenesulfonamide And the article was included in Chemical Data Collections in 2020. The article conveys some information:

The oxidation of N-(2-hydroxyethyl)phthalimide (NHEP) by chloramine T (CAT) in perchloric acid medium has been investigated iodometrically at 298 K. The stoichiometry of the reaction was found to be 1:2. The oxidation products were identified by LC-MS anal. Kinetic orders with respect to oxidant, substrate and acid concentrations were determined Enhancement of rate observed with an increase in acid concentration Effect of solvent polarity and ionic strength was studied. Addition of p-toluene sulfonamide (reductant) to the reaction mixture has no significant influence on the rate. The active species of the oxidant in acidic medium was ascertained. Plausible mechanistic scheme explaining all of the observed kinetic results have been proposed. The effect of temperature on the reaction rates has also been studied. Activation parameters and thermodn. quantities were evaluated and discussed. The rate constant of the slow step of the reaction along with the equilibrium constants were also calculated The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《AuCl3-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis》 was published in Chemistry – A European Journal in 2020. These research results belong to Wang, Rui; Chen, Yi; Shu, Mao; Zhao, Wenwen; Tao, Maoling; Du, Chao; Fu, Xiaoya; Li, Ao; Lin, Zhihua. SDS of cas: 70-55-3 The article mentions the following:

A highly efficient AuCl3-catalyzed intramol. ring-closing carbonyl-olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes I (R = C(O)OEt, Ph, COPh, CONHPh; Ar = Ph, 3-methoxyphenyl, furan-2-yl, etc.), polycycles e.g., II, benzocarbocycles e.g., III, and N-heterocycle derivatives IV (R1 = Ph, 4-fluorophenyl, naphthalen-2-yl, etc.) in good to excellent yields.4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics