Category: 70-55-3

Reference of 4-MethylbenzenesulfonamideIn 2021 ,《Bronsted Acid Promoted N-Dealkylation of N-Alkyl(sulfon)amides》 appeared in ChemistrySelect. The author of the article were Gu, Linghui; Wang, Yang; Cheng, Zemin; Sun, Yanan; Gong, Xin; Li, Zheyu; Ma, Wenbo. The article conveys some information:

A simple and efficient Bronsted-acid-promoted N-dealkylation of N-alkylsulfonamides RS(O)2NHR1 (R = 4-chlorophenyl, 1-naphthyl, thiophen-2-yl, etc.; R1 = t-Bu, cyclopropyl) and N-alkylamides R2C(O)NHR3 (R2 = benzyl, 1-naphthyl, biphenyl-2-yl, thiophen-3-yl, etc.; R3 = t-Bu, cyclopropyl) has been developed. This strategy features an ample substrate scope with excellent chem. selectivity, affording primary (sulfon)amide derivatives RS(O)2NH2 and R2C(O)NH2 in moderate to good yields without the need for transition-metal catalysts. After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Chemical Science included an article by Zhang, Ziyan; Yadagiri, Dongari; Gevorgyan, Vladimir. Synthetic Route of C7H9NO2S. The article was titled 《Light-induced metal-free transformations of unactivated pyridotriazoles》. The information in the text is summarized as follows:

A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse mols. were developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which were capable of smooth arylation, X-H insertion and cyclopropanation reactions. The synthetic usefulness of the developed method was illustrated in a facile synthesis of biol. active mols. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Copper-catalyzed carbonylative synthesis of β-homoprolines from N-fluoro-sulfonamides》 was published in Organic Letters in 2020. These research results belong to Zhang, Youcan; Yin, Zhiping; Wu, Xiao-Feng. Recommanded Product: 70-55-3 The article mentions the following:

A new methodol. for the carbonylative transformation of N-fluoro-sulfonamides into N-sulfonyl-β-homoproline esters has been described. In the presence of a catalytic amount of Cu(OTf)2, a range of β-homoproline derivatives were prepared in moderate to good yield. The reaction proceeds via the intramol. cyclization and intermol. carbonylation of a free carbon radical. Notably, this procedure offers the possibility to build potential functionalized bioactive mols. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 70-55-3In 2022 ,《Visible Light-Mediated Late-stage Sulfonylation of Anilines with Sulfonamides》 was published in Organic Letters. The article was written by Xu, Xiao-Hong; Zhen, Jing-Song; Du, Xian; Yuan, Han; Li, Yi-Hui; Chu, Man-Hei; Luo, Yong. The article contains the following contents:

A visible light-mediated late-stage sulfonylation of anilines with sulfonamides under simple reaction conditions is presented. Various primary or secondary sulfonamides including several pharmaceuticals were incorporated successfully via N-S bond activation and C-H bond sulfonylation. The synthetic utility of this strategy is highlighted by the construction of complex anilines bearing diverse bioactive groups. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis of Imides, Imidates, Amidines, and Amides by Intercepting the Aryne-Isocyanide Adduct with Weak Nucleophiles》 were Ghorai, Sourav; Lee, Daesung. And the article was published in Organic Letters in 2019. Computed Properties of C7H9NO2S The author mentioned the following in the article:

New aryne-based multicomponent coupling reactions for the formation of functionalized aromatic compounds have been developed. Arynes generated from triynes or tetraynes through the hexadehydro Diels-Alder reaction readily react with isocyanide to generate nitrilium intermediate. Intercepting this nitrilium species with various weak nucleophile including carboxylic acids, alcs., sulfonamides, or water generated the corresponding imides, imidates, amidines, or amides. The high regioselectivity of these transformations was mainly controlled by the substituents of the arynes. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Oxidative sulfamidation of vinyl silanes: A route to diverse silylated N-Heterocycles》 were Astakhova, Vera V.; Shainyan, Bagrat A.; Moskalik, Mikhail Yu.; Sterkhova, Irina V.. And the article was published in Tetrahedron in 2019. Product Details of 70-55-3 The author mentioned the following in the article:

The reaction of trimethyl(vinyl)silane 1 and dimethyl(divinyl)silane 2 with various sulfonamides in the oxidative system (tert-BuOCl + NaI) has been studied and shown to be an efficient approach for the synthesis of silylated N-heterocycles. Triflamide demonstrated the reactivity principally different from that of arenesulfonamides. With silane 1, it afforded the products of iodochlorination and bis(triflamidation) (major), whereas arenesulfonamides gave N-arenesulfonylaziridines in up to 91% yield. Silane 2 with arenesulfonamides yielded the products of mono and bis(iodochlorination), mono and bis(aziridination), and 3,5-diiodo-4,4-dimethyl-1-(arylsulfonyl)-1,4-azasilinanes. By contrast, triflamide, apart from the products of halogenation and iodotriflamidation, unexpectedly gave 3-(trifluoromethylsulfonyl)-5-(triflamido)oxazolidine as the main product. The structure of most heterocyclic products is proved by X-ray anal. The effect of the silyl group in the substrate and of the substituent in the reagent on the course of oxidative sulfamidation is discussed by comparing with all-carbon analogs.4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Kinetics and mechanistic study of oxidation of paracetamol: an accelerated catalytic approach》 were Negi, Reena; Jain, Bhawana; Singh, Sunita; Singh, Ajaya Kumar; Asthana, Anupama. And the article was published in SN Applied Sciences in 2019. Quality Control of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

In the present paper, a simple, and novel method for the abatement of paracetamol (PA) in aqueous system into environmental friendly compound benzoquinone at 308 K has been described, and was accelerated by simple, and inexpensive catalyst Cu(II)/Ni(II). A comparative assessment between Cu(II) and Ni(II)catalyzed, abatement of PA by CAT was performed. It has been determined that there are very little change in rate of reaction for both Cu(II)/Ni(II) catalyzed degradation of PA. All the kinetics parameters, i.e. the effect of change in concentrations of chloramine-T (CAT), sodium hydroxide, paracetamol, catalyst, added p-toluenesulfonamide, electrolyte etc. have been studied, and measured carefully. Reaction had been studied in the range of temperature 303-323 K. On the basis of kinetic data obtained a satisfactory mechanism has been proposed. And it was deduced that, presently used process was a tenable technique for the degradation of PA. Main abatement product was confirmed by GC-MS anal. technique. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Marcyk, Paul T.; Cook, Silas P.. Safety of 4-Methylbenzenesulfonamide. The article was titled 《Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes》. The information in the text is summarized as follows:

The hydrofunctionalization of alkenes, explored for over 100 years, offers the potential for a direct, atom-economical approach to value-added products. While thermodynamically favored, the kinetic barrier to such processes necessitates the use of catalysts to control selectivity and reactivity. Modern variants typically rely on noble metals that require different ligands for each class of hydrofunctionalization, thereby limiting generality. This Letter describes a general iron-based system that catalyzes the hydroamination and hydroetherification of simple unactivated olefins. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 70-55-3In 2019 ,《Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement》 was published in Nature Communications. The article was written by Zhou, Bo; Zhang, Ying-Qi; Zhang, Kairui; Yang, Ming-Yang; Chen, Yang-Bo; Li, You; Peng, Qian; Zhu, Shou-Fei; Zhou, Qi-Lin; Ye, Long-Wu. The article contains the following contents:

Here a metal-free intramol. hydroalkoxylation/[1,3]-rearrangement was reported, leading to the practical and atom-economical assembly of valuable medium-sized lactams such as I [R1 = Me, Et, Ph; R2 = Me, Ph, 2-naphthyl, etc.; R3 = 8-Me, 9-Cl, 8-Br, etc.; R4 = SO2Ph, Ts, Bs] with wide substrate scope and excellent diastereoselectivity. Moreover, such an asym. cascade cyclization was realized by chiral Bronsted acid-catalyzed kinetic resolution In addition, antitumor activity tests revealed that that some of these medium-sized lactams displayed their bioactivity as antitumor agents against melanoma cells, esophageal cancer cells and breast cancer cells. A mechanistic rationale for the reaction was further supported by control experiments and theor. calculations The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 70-55-3In 2019 ,《High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides》 was published in Organic Letters. The article was written by Becica, Joseph; Hruszkewycz, Damian P.; Steves, Janelle E.; Elward, Jennifer M.; Leitch, David C.; Dobereiner, Graham E.. The article contains the following contents:

Through targeted high-throughput experimentation (HTE), authors have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chem. AdBippyPhos is particularly effective for the installation of heteroaromatic groups. Computational steric parametrization of the investigated ligands reveals the potential importance of remote steric demand, where a large cone angle combined with an accessible Pd center is correlated to successful catalysts for C-N coupling reactions. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics