Category: 70-55-3

《Halogen Bond Induced Consecutive Csp3-H Aminations via Hydrogen Atom Transfer (HAT) Relay Strategy》 was published in Organic Letters in 2020. These research results belong to Wu, Fan; Ariyarathna, Jeewani P.; Kaur, Navdeep; Alom, Nur-E.; Kennell, Maureen L.; Bassiouni, Omar H.; Li, Wei. Computed Properties of C7H9NO2S The article mentions the following:

An uncommon use of halogen bonding to induce intermol. Csp3-H amination while enabling a HAT relay strategy to access privileged pyrrolidines I [R = Me, Et, 4-OMeC6H4; Ar = Ph, 4-FC6H4, 4-BrC6H4, etc.] directly from alkanes was disclosed. Mechanistic studies support the presence of multiple halogen bond interactions at distinct reaction stages. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kiyosu, Yuuki; Tanaka, Shino; Okumura, Sota; Kiyokawa, Kensuke; Minakata, Satoshi published an article in 2021. The article was titled 《Synthesis of Fused Diaziridine Derivatives from Cyclic Secondary Amines by Utilizing N-Bromosulfonamide as an Aminating Reagent》, and you may find the article in Synthesis.Related Products of 70-55-3 The information in the text is summarized as follows:

The synthesis of a series of fused diaziridines such as I (Ts = 4-MeC6H4SO2) which are difficult to access by existing methods, was achieved by the reaction of cyclic secondary amines with p-toluenesulfonamide in the presence of N-bromosuccinimide (NBS) and a suitable base. This oxidation system enables the efficient in situ formation of the key intermediates, which are N-bromoamines (a precursor of cyclic imines) and N-bromosulfonamides. In addition, an alternative method using N-bromo-N-sodio-p-toluenesulfonamide (bromamine-T) in the presence of a catalytic amount of CF3CO2H for the synthesis of fused diaziridines is also reported. The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《1-Tosyl-6-vinyl-4,5,6,7-tetrahydro-1H-benzo[d]imidazole-2-amine》 was written by Meany, Fiach B.; O’Rourke, Sarah; Murphy, Paul V.. HPLC of Formula: 70-55-3This research focused ontosyl vinyl tetrahydro benzimidazole amine preparation; epoxide ring opening amino alc oxidation condensation. The article conveys some information:

The alkene functionalized 2-aminobenzimidazole ring found in terrazoanthine natural products was synthesized in 3 steps from 1,2-epoxy-4-vinylcyclohexane via epoxide ring opening with toluenesulfonamide yielding 2 regioisomeric, separable amino alcs. One isomer was oxidized to the corresponding ketone and subsequently condensed with cyanamide to furnish the title compound, which was characterized by 1H-NMR and 13C-NMR spectroscopy. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Kai; Yang, Jianfeng; Li, Xiaoxun published their research in Organic Letters in 2021. The article was titled 《Palladium-Catalyzed Diastereo- and Enantioselective [3 + 2] Cycloaddition of Vinylcyclopropanes with Azadienes: Efficient Access to Chiral Spirocycles》.Reference of 4-Methylbenzenesulfonamide The article contains the following contents:

The first palladium(0)-catalyzed diastereo- and enantioselective [3 + 2] annulation of vinylcyclopropanes (VCPs) I (R = methoxycarbonyl, (2,2,2-trifluoroethoxy)carbonyl, cyano) and BDAs II (R1 = Me, 4-methylphenyl, 4-bromophenyl; R2 = H, 6-Cl, 5-Br, 6-OMe; R3 = Ph, naphthalen-1-yl, thiophen-2-yl, etc.; X = C, O, S) and 2-(phenylmethylidene)-2,3-dihydro-1-benzothiophen-3-one were reported. This transformation is featured with a broad substrate scope III and IV, allowing for facile access to a variety of enantioenriched spirocycles bearing a quaternary stereogenic center in good yields with excellent regio-, diastereo-, and enantioselectivities (up to 93% yield, >20:1 dr, and mostly >99% ee) under mild reaction conditions. Moreover, the spirocyclic products III and IV could be efficiently converted to structurally complex tricyclo[8.3.0.01,5]-azatridecane and tricyclo[7.3.0.01,5]-azadodecane skeletons. The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Enantioselective Construction of Chiral Sulfides via Catalytic Electrophilic Azidothiolation and Oxythiolation of N-Allyl Sulfonamides》 were Liang, Yaoyu; Zhao, Xiaodan. And the article was published in ACS Catalysis in 2019. Reference of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

An efficient and convenient pathway was developed for enantioselective synthesis of chiral sulfides by chiral bifunctional selenide-catalyzed electrophilic azidothiolation and oxythiolation of N-allyl sulfonamides. By this protocol, a variety of chiral vicinal azidosulfides and oxysulfides were obtained in good yields with high enantioselectivities and diastereoselectivities. In this transformation, not only electrophilic arylthiolating reagents but also a wide range of electrophilic alkylthiolating reagents worked very well. The practical application of this method was elucidated by further transformations of the products into the diversified compounds The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Rhodium(III)-Catalyzed Oxidative Annulation of Ketoximes with Sulfonamide: A Direct Approach to Indazoles》 were Wang, Ning; Liu, Lingling; Xu, Wentao; Zhang, Mengye; Huang, Zhibin; Shi, Daqing; Zhao, Yingsheng. And the article was published in Organic Letters in 2019. Synthetic Route of C7H9NO2S The author mentioned the following in the article:

A rhodium(III)-catalyzed intermol. C-H amination of ketoxime and iodobenzene diacetate-enabled N-N bond formation in the synthesis of indazoles has been developed. A variety of functional groups were well tolerated, providing the corresponding products in moderate to good yields. Moreover, the nitro-substituted ketoximes are well compatible in this reaction, leading to the corresponding products in moderate to good yields.4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Chemical Science included an article by Tang, Nana; Wu, Xinxin; Zhu, Chen. Computed Properties of C7H9NO2S. The article was titled 《Practical, metal-free remote heteroarylation of amides via unactivated C(sp3)-H bond functionalization》. The information in the text is summarized as follows:

A new, efficient, site-selective heteroarylation of amides via C(sp3)-H bond functionalization. Amidyl radicals were directly generated from the amide N-H bonds under mild conditions, which triggered the subsequent 1,5-HAT process. A wide scope of aliphatic amides including carboxamides, sulfonamides and phosphoramides were readily modified at remote C(sp3)-H bonds by installing diverse heteroaryl groups. Borne out of pragmatic consideration, this protocol was used for the late-stage functionalization of amides. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant》 were Yao, Wei-Wei; Li, Ran; Li, Jiang-Fei; Sun, Juan; Ye, Mengchun. And the article was published in Green Chemistry in 2019. Computed Properties of C7H9NO2S The author mentioned the following in the article:

A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand compound I significantly promoted the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand compound II afforded the products in 51-95% ee. The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Zhen, Jingsong; Du, Xian; Xu, Xiaohong; Li, Yihui; Yuan, Han; Xu, Dejing; Xue, Can; Luo, Yong published an article in ACS Catalysis. The title of the article was 《Visible-Light-Mediated Late-Stage Sulfonylation of Boronic Acids via N-S Bond Activation of Sulfonamides》.Electric Literature of C7H9NO2S The author mentioned the following in the article:

A visible-light-mediated late-stage arylation of N-S bonds in sulfonamides was developed with using readily available imines as sulfonyl radical source. Diverse complex sulfones could be synthesized by prefunctionalization and subsequent N-S bond arylation, demonstrating the advantages of using sulfonamides as sulfonylation reagents. Addnl., the mechanism research revealed that probably both EDA complex chem. and photoredox catalysis were responsible for the formation of sulfones. This methodol. characterized by broad substrate scope and simple reaction conditions also has high atom economy, since the aldehyde for the synthesis of imines could be recovered after workup of the reactions. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C7H9NO2SIn 2022 ,《Fluorogenic detection of sulfite in water by using copper(II) azacyclam complexes》 was published in Molecules. The article was written by Ciarrocchi, Carlo; Sacchi, Donatella; Boiocchi, Massimo; Weththimuni, Maduka Lankani; Orbelli Biroli, Alessio; Licchelli, Maurizio. The article contains the following contents:

Copper(II) azacyclam complexes (azacyclam = 1,3,5,8,12-pentaazacyclotetradecane) containing naphthyl or dansyl subunits can be prepared by template synthesis involving proper sulfonamide derivatives as locking fragments. The macrocyclic complexes are very poorly emissive due to the fluorescence-quenching behavior displayed by Cu2+ ions. However, the fluorescence can be recovered as a result of the decomposition of the complexes, which induces the release of free light-emitting subunits to the solution This reaction takes place very slowly in neutral water but its rate is increased by the presence of sulfite. Therefore, [Cu(azacyclam)]2+ derivatives have been investigated as simple chem. probes for the fluorogenic detection of sulfite both on laboratory and real samples. Preliminary tests performed on samples of white wine provided sulfite concentration values that are in agreement with those obtained by a standard anal. method. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics