Category: 698-67-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 698-67-9, name is 4-Bromobenzamide, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H6BrNO

The under nitrogen atmosphere, 4-bromobenzamide (597 mg, 3 mmol, 1.0 eq.) was dissolved in 25 ml of triethylamine, and then added trimethylsilylacetylene (2.94 g, 30 mmol, 10 eq), bis(triphenylphosphine) palladium dichloride (421 mg, 0.6 mmol, 0.2 eq.), cuprous iodide (228 mg, 1.2 mmol, 0.4 eq.). The reaction mixture was heated to 50 °C with stirring. Reaction was diluted with ethyl acetate release, filtered through Celite, washed twice with ethyl acetate, and the filtrate was concentrated in vacuo, the residue was purified by to give the title compound as a brown oil was purified by column 4-trimethylsilylethynylbenzamide (780 mmol g, crude).

According to the analysis of related databases, 698-67-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangzhou Kaisheng Beite Pharmaceutical Co., Ltd.; Cai, Xiong; Qian, Changgeng; Liu, Bin; Li, Junqi; Lin, Mingsheng; Qing, Yuanhui; Weng, Yunwo; Wang, Yanyan; Xue, Weicai; You, Huajin; Zhou, Shiqing; (67 pag.)CN105622638; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 698-67-9, These common heterocyclic compound, 698-67-9, name is 4-Bromobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A Schlenk tube was charged with Cu2O (7.2 mg, 10 molpercent), l-proline (11.5 mg, 20 molpercent), aryl (or heteroaryl) bromide (1 or 3,0.50 mmol), potassium iodide (KI) (249 mg, 0.75 mmol), and EtOH(1.5 mL) under nitrogen atmosphere. The Schlenk tube was sealedwith a teflon valve, and then the reaction mixture was stirred at110C for a period (the reaction progress was monitored by GCanalysis). After the reaction was completed, GC yield of high volatileproduct was determined using an appropriate internal standard(chlorobenzene or 1-chloro-4-methylbenzene) or the solvent wasremoved under reduced pressure. The residue obtained was puri-fied via silica gel chromatography (eluent: petroleum ether/ethylacetate = 10/1) to afford aryl iodides 2a?2o or heteroaryl iodides4a?4g.

Statistics shows that 4-Bromobenzamide is playing an increasingly important role. we look forward to future research findings about 698-67-9.

Reference:
Article; Feng, Xiujuan; Li, Lingyu; Yu, Xiaoqiang; Yamamoto, Yoshinori; Bao, Ming; Catalysis Today; vol. 274; (2016); p. 129 – 132;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics