European Journal of Medicinal Chemistry published new progress about Caspase recruitment domain-containing protein 15 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (inhibitor). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, HPLC of Formula: 6961-82-6.
Ma, Yao; Li, Xueyuan; Pei, Yameng; Ye, Jingjia; Wei, Xiduan; Yang, Jingshu; Si, Guangxu; Tian, Jingyuan; Dong, Yi; Liu, Gang published the artcile< Identification of benzofused five-membered sultams, potent dual NOD1/NOD2 antagonists in vitro and in vivo>, HPLC of Formula: 6961-82-6, the main research area is nucleotide binding oligomerization domains NOD1 NOD2 antagonist NFkappaB MAPK; Dual NOD1/NOD2 antagonist; Five-membered sultams; MAPK signaling; NF-κB signaling.
Nucleotide-binding oligomerization domain-containing proteins 1 and 2 play important roles in immune system activation. Recently, a shift has occurred due to the emerging knowledge that preventing nucleotide-binding oligomerization domains (NODs) signaling could facilitate the treatment of some cancers, which warrants the search for dual antagonists of NOD1 and NOD2. Herein, we undertook the synthesis and identification of a new class of derivatives of dual NOD1/NOD2 antagonists with novel benzofused five-membered sultams. Compound 14k(I) was finally demonstrated to be the most potent mol. that inhibits both NOD1-and NOD2-stimulated NF-κB and MAPK signaling in vitro and in vivo.
European Journal of Medicinal Chemistry published new progress about Caspase recruitment domain-containing protein 15 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (inhibitor). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, HPLC of Formula: 6961-82-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics