Category: 6961-82-6

Liu, Peng; Chen, Xiaozhong; Xu, Xiangchao; Yang, Linlin; Zeng, Guixiang; Ye, Chuang; Shi, Qixun; Yang, Jiazhi; Li, Feng published the artcile< From hydrogen autotransfer process to deuterium autotransfer process: The N-trideuteromethylation of amines with deuterated methanol to trideuteromethylated amines catalyzed by a Cp*Ir complex bearing a flexible bridging and functional ligand>, Category: amides-buliding-blocks, the main research area is perdeuteromethanol amine iridium catalyst trideuteromethylation green chem; trideuteromethylamine preparation; sulfonamide perdeuteromethanol iridium catalyst trideuteromethylation green chem; trideuterosulfonamide preparation.

A Cp*Ir complex bearing a flexible and functional 6,6′-(OH)2-2,2′-dipyridylamine ligand was designed, synthesized and found to be a general and efficient catalyst for the synthesis of trideuteromethylated amines via the N-trideuteromethylation of amines with deuterated methanol based on the proposed deuterium autotransfer process. The synthetic strategy was attractive due to easily available deuterium source, high atom efficiency and environmental friendliness. It was confirmed that OH units in the ligand were crucial for the catalytic activity. Furthermore, a metal-ligand cooperative mechanism was also proposed based on exptl. results and DFT calculations

Journal of Catalysis published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chinn, Alex J.; Sedillo, Kassandra; Doyle, Abigail G. published the artcile< Phosphine/Photoredox Catalyzed Anti-Markovnikov Hydroamination of Olefins with Primary Sulfonamides via α-Scission from Phosphoranyl Radicals>, Quality Control of 6961-82-6, the main research area is secondary sulfonamide preparation; primary sulfonamide alkene antiMarkovnikov hydroamination phosphine iridium photocatalyst.

A dual phosphine and photoredox catalytic system that enables direct formation of sulfonamidyl radicals from primary sulfonamides RSO2NH2 (R = 4-tert-butylphenyl, Me, cyclopropyl, thiophen-2-yl, etc.) was reported. Mechanistic investigations support that the N-centered radical is generated via α-scission of the P-N bond of a phosphoranyl radical intermediate, formed by sulfonamide nucleophilic addition to a phosphine radical cation. As compared to the recently well-explored β-scission chem. of phosphoranyl radicals, this strategy is applicable to activation of N-based nucleophiles and is catalytic in phosphine. The application of this activation strategy to an intermol. anti-Markovnikov hydroamination of unactivated olefins (such as cyclohexene, hex-1-ene, styrene, etc.) with primary sulfonamides RSO2NH2 is highlighted. A range of structurally diverse secondary sulfonamides [such as 4-(tert-butyl)-N-hexylbenzenesulfonamide, 4-(tert-butyl)-N-(3-phenylpropyl)benzenesulfonamide, 2-chloro-N-cyclohexylbenzenesulfonamide, etc.] can be prepared in good to excellent yields under mild conditions.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Quality Control of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Meng, Chong; Liu, Peng; Nguyen, Thanh Tung; Han, Xingyou; Li, Feng published the artcile< N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal-Ligand Bifunctional Dinuclear Iridium Catalyst>, Product Details of C6H6ClNO2S, the main research area is sulfonamide methanol iridium catalyst methylation green chem; methylsulfonamide preparation; amine methanol iridium catalyst methylation; methylamine preparation green chem.

The N-methylation of amines with methanol in aqueous solution was proposed and accomplished by using a water-soluble metal-ligand bifunctional dinuclear iridium catalyst. In the presence of [(Cp*IrCl)2(thbpym)][Cl]2 (1 mol%), a range of desirable products were obtained in high yields under environmentally benign conditions. Notably, this research exhibited the potential of transition metal-catalyzed the activation of methanol as a C1 source for the construction of C-N bond in aqueous solution

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Product Details of C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dong, Wei; Ge, Zemei; Wang, Xin; Li, Ridong; Li, Runtao published the artcile< Cu-mediated one-pot three-component synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives>, Quality Control of 6961-82-6, the main research area is halobenzenesulfonamide amine carbon disulfide copper catalyst three component reaction; amino benzodithiazine dioxide preparation.

A novel and efficient copper-catalyzed one-pot procedure for the synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives from 2-halobenzenesulfonamides, amines and CS2 was described. The reaction proceeded through Ullmann-type S-arylation, intramol. addition of NH2 with C=S and dehydrosulfide, which provided a new and useful strategy for construction of cyclic aromatic sulfonamides.

Tetrahedron published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Quality Control of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Whalley, David M.; Duong, Hung A.; Greaney, Michael F. published the artcile< Alkene Carboarylation through Catalyst-Free, Visible Light-Mediated Smiles Rearrangement>, Safety of o-Chlorobenzenesulfonamide, the main research area is aliphatic ester preparation carboarylation arenesulfonamide alkene Truce Smiles rearrangement; acetamide preparation tandem photoredox carboarylation Truce Smiles rearrangement; aromatic substitution; arylation; photochemistry; radical reactions; rearrangement.

A light-mediated Truce-Smiles arylative rearrangement is described that proceeds in the absence of any photocatalyst. The protocol creates two C-C bonds from simple starting materials, with the installation of an aryl ring and a difluoroacetate moiety across unactivated alkenes. The reaction proceeds via a radical mechanism, utilizing a light-mediated reduction of Et bromodifluoroacetate by N,N,N’,N’-tetramethylethylenediamine (TMEDA) to set up intermol. addition to an unactivated alkene, followed by Truce-Smiles rearrangement.

Chemistry – A European Journal published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Safety of o-Chlorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Deepak K.; Adams, Spencer T.; Liebmann, Kate L.; Choi, Adam; Miller, Stephen C. published the artcile< Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes>, Formula: C6H6ClNO2S, the main research area is sulfonamide firefly luciferase bioluminescence fluorescent dye.

Many fluorophores, and all bright light-emitting substrates for firefly luciferase, contain hydroxyl or amine electron donors. Sulfonamides were found to be capable of serving as replacements for these canonical groups. Unlike “”caged”” carboxamides, sulfonamide donors enable bioluminescence, and sulfonamidyl luciferins, coumarins, rhodols, and rhodamines are fluorescent in water.

Organic Letters published new progress about Absorptivity. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Formula: C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Zhen; Zhang, Yan-Shun; Wei, Yin; Shi, Min published the artcile< Metal-Free Synthesis of Polysubstituted Imidazolinone Through Cyclization of Amidines with 2-Substituted Acrylates>, COA of Formula: C6H6ClNO2S, the main research area is imidazolinone preparation; nucleophilic cyclization benzamidine sulfonylaminoacrylate.

Imidazolidinones such as I (R = 4-MeC6H4, 4-EtC6H4, 4-t-BuC6H4, 4-MeOC6H4, Ph, 4-O2NC6H4, 2-O2NC6H4, 4-FC6H4, 2-ClC6H4, 4-BrC6H4) were prepared by nucleophilic cyclization reaction of (sulfonylamino)acrylates H2CC(NHSO2R)CO2R1 (R = 4-MeC6H4, 4-EtC6H4, 4-t-BuC6H4, 4-MeOC6H4, Ph, 4-O2NC6H4, 2-O2NC6H4, 4-FC6H4, 2-ClC6H4, 4-BrC6H4; R1 = Me, Et, Ph, PhCH2) with benzamidines such as N-phenylbenzamidine in 1,2-dichloroethane at ambient temperature

European Journal of Organic Chemistry published new progress about Benzamidines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, COA of Formula: C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Tao; Hua, Jiawei; Bian, Mixue; Qin, Hong; Lin, Xinxin; Yang, Xiaobing; Liu, Chengkou; Yang, Zhao; Fang, Zheng; Guo, Kai published the artcile< Visible light-promoted aerobic oxidative cleavage and cyclization of olefins to access 3-hydroxy-isoindolinones>, Related Products of 6961-82-6, the main research area is alkenylbenzamide iron catalyst photochem regioselective aerobic oxidative cleavage heterocyclization; hydroxy isoindolinone preparation green chem.

A convenient and environmentally friendly synthetic route from 2-vinylbenzimides to 3-hydroxy-isoindolinones through visible light-promoted transformations via iron/disulfide catalysis and mol. oxygen oxidation was developed. A range of 3-hydroxy-isoindolinones were obtained in moderate to good yields, which exhibited excellent functional group compatibility and broad substrate scope. Further mechanistic investigations proved that dioxetane might be a key intermediate being involved in the reaction.

Organic Chemistry Frontiers published new progress about Amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Related Products of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Markushyna, Yevheniia; Schuesslbauer, Christoph M.; Ullrich, Tobias; Guldi, Dirk M.; Antonietti, Markus; Savateev, Aleksandr published the artcile< Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst>, Related Products of 6961-82-6, the main research area is chromoselective synthesis sulfonyl chloride sulfonamide potassium polyheptazine imide photocatalyst; carbon nitride; chromoselective catalysis; organic synthesis; photoredox catalysis; sulfonyl chloride.

Among external stimuli used to promote a chem. reaction, photocatalysis possesses a unique one-light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryl disulfides at green to red light (e.g., S-Ph thioacetate → benzenesulfonyl chloride (93%) under blue light irradiation using HCl in water/MeCN and O2 as electron acceptor). A combination of the neg. charged polyanion, highly pos. potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

Angewandte Chemie, International Edition published new progress about Arenesulfonyl chlorides Role: SPN (Synthetic Preparation), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Related Products of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hopkins, Megan D.; Ozmer, Garett L.; Witt, Ryan C.; Brandeburg, Zachary C.; Rogers, David A.; Keating, Claire E.; Petcoff, Presley L.; Sheaff, Robert J.; Lamar, Angus A. published the artcile< PhI(OAc)2 and iodine-mediated synthesis of N-alkyl sulfonamides derived from polycyclic aromatic hydrocarbon scaffolds and determination of their antibacterial and cytotoxic activities>, COA of Formula: C6H6ClNO2S, the main research area is alkyl sulfonamide preparation antibacterial antitumor physicochem human.

The development of new approaches toward chemo- and regioselective functionalization of polycyclic aromatic hydrocarbon (PAH) scaffolds will provide opportunities for the synthesis of novel biol. active small mols. that exploit the high degree of lipophilicity imparted by the PAH unit. Herein, new synthetic method for C-X bond substitution that is speculated to operate via a N-centered radical (NCR) mechanism according to exptl. observations was reported. A series of PAH sulfonamides have been synthesized and their biol. activity has been evaluated against Gram-neg. and Gram-pos. bacterial strains (using a BacTiter-Glo assay) along with a series of mammalian cell lines (using CellTiter-Blue and CellTiter-Glo assays). The viability assays have resulted in the discovery of a number of bactericidal compounds that exhibit potency similar to other well-known antibacterials such as kanamycin and tetracycline, along with the discovery of a luciferase inhibitor. Addnl., the physicochem. and drug-likeness properties of the compounds were determined exptl. and using in silico approaches and the results are presented and discussed within.

Organic & Biomolecular Chemistry published new progress about Antibacterial agents. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, COA of Formula: C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics