Category: 6961-82-6

Liu, Yahuan; Wang, Zheng; Zhao, Ziwei; Gao, Pengxiang; Ma, Ning; Liu, Qingbin published the artcile< Efficient base-free hydrodehalogenation of organic halides catalyzed by a well-defined diphosphine-ruthenium(II) complex>, SDS of cas: 6961-82-6, the main research area is aryl alkyl chloride bromide hydrodehalogenation diphosphine ruthenium catalyst.

A base-free, robust catalytic system based on the diphosphine-ruthenium(II) complex cation has been developed for the hydrodehalogenation of a wide range of aryl- and alkyl-chlorides/bromides (27 examples) with mol. hydrogen. Notably, the reaction proceeds at 120°C with low catalyst loading (0.1 mol%) and exhibits a good tolerance toward functional groups, such as amido, carboxyl, sulfonyl, methoxyl, ester groups. Moreover, a mechanism for the diphosphine-ruthenium(II) complex cation catalyzed dehalogenation process has been proposed. This hydrodehalogenation methodol. shows a potential application for the organic transformation and degradation of organic halides.

Molecular Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, SDS of cas: 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guerra, Walter D.; Lucena-Agell, Daniel; Hortigueela, Rafael; Rossi, Roberto A.; Fernando Diaz, J.; Padron, Jose M.; Barolo, Silvia M. published the artcile< Design, Synthesis, and in vitro Evaluation of Tubulin-Targeting Dibenzothiazines with Antiproliferative Activity as a Novel Heterocycle Building Block>, Application In Synthesis of 6961-82-6, the main research area is dibenzothiazine preparation antiproliferative SAR cell cycle tubulin inhibitor human; Antiproliferation; dibenzothiazines; drug design; sulfonamides; tubulin inhibitors.

A series of free NH and N-substituted dibenzonthiazines I [R1 = H, F, CF3, Ph; R2 = H, 9-F, 7-Ph, etc.; R3 = H, Me, Bn, etc.] with potential anti-tumor activity from N-aryl-benzenesulfonamides was prepared A biol. test of synthesized compounds was performed in vitro measuring their antiproliferative activity against a panel of six human solid tumor cell lines and its tubulin inhibitory activity. Compounds I [R1 = R2 = H; R3 = SO2C6H5, 4-MeC6H4SO2] showed as the best compounds with promising values of activity (overall range of 2-5.4μM).

ChemMedChem published new progress about Antiproliferative agents. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jia, Yibo; Li, Lin; Duan, Lili; Li, Yue-Ming published the artcile< The aza-Prins Cyclization of Unfunctionalized Olefins Promoted by NHC-Cu Complex and ZrCl4>, Related Products of 6961-82-6, the main research area is piperidine preparation diastereoselective zirconium tetrachloride NHC copper catalyst; homoallylic amine aldehyde aza Prins cyclization.

The aza-Prins cyclization reaction catalyzed by ZrCl4 and NHC (N-heterocyclic carbene) metal complexes is firstly reported. NHC-copper complexes as promoter and ZrCl4 as chloride source are utilized under a mild condition, where homoallylic amines and aldehydes are successfully converted to piperidine derivatives in satisfactory yields and diastereoselectivity.

Applied Organometallic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Related Products of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Kui; Li, Yajun published the artcile< Solid-liquid phase equilibrium and solution thermodynamics of 2-chlorobenzenesulfonamide in 16 mono solvents at temperature ranging from 273.15 K to 324.65 K>, Application In Synthesis of 6961-82-6, the main research area is chlorobenzenesulfonamide solid liquid phase equilibrium solution thermodn.

The synthesis and separation processes of chem. intermediate is based on the knowledge of its solid-liquid phase equilibrium with solvents in industry. In this work, the solubility of 2-chlorobenzenesulfonamide in 16 single pure solvents including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, 2-butanone, 2-pentanone, cyclohexanone, cyclopentanone, Et acetate, Me acetate, Et formate, acetonitrile and THF was determined at temperature range from 273.15 to 324.65 K and atm. pressure. The mole fraction solubility of 2-chlorobenzenesulfonamide in all selected mono solvents was enhanced by an increase in temperature In addition, the exptl. data were further correlated by the modified Apelblat equation, λh equation, NRTL model and Wilson model. The values of RAD with NRTL equation were smaller than those with other three models, and thus the NRTL model offered the best fitting performance. The thermodn. functions of dissolution including enthalpy, entropy, and Gibbs energy were derived, and the results expectedly suggested a spontaneous and entropy-driven mixing process. All the crystallog. and thermodn. data reported in this study provides the fundamental data for designing and optimizing of the reaction and crystallization processes of 2-chlorobenzenesulfonamide.

Journal of Molecular Liquids published new progress about Crystallization. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vu, Huu-Manh; Yong, Jia-Yuan; Chen, Fei-Wu; Li, Xu-Qin; Shi, Guo-Qing published the artcile< Rhodium-Catalyzed C(sp2)-H Amidation of Azine with Sulfonamides>, Quality Control of 6961-82-6, the main research area is regioselective rhodium catalyzed amidation azine sulfonamide.

Direct C-H amidation of azine with sulfonamide was developed for the first time. The reactions proceeded smoothly under benign conditions and gave the corresponding products with high selectivity. This approach shows high regioselectivity, wide substrate scope, and functional group tolerance. Addnl., this transformation can also be scaled up to the gram level. This strategy allows for the direct preparation of ortho-sulfonamide-substituted ketone products, thus providing a good complement to previous C-H amidation.

Journal of Organic Chemistry published new progress about Amidation. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Quality Control of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dong, Pei; Li, Zhaojing; Liu, Xiaohua; Dong, Shunxi; Feng, Xiaoming published the artcile< Asymmetric synthesis of polycyclic spiroindolines via the Dy-catalyzed cascade reaction of 3-(2-isocyanoethyl)indoles with aziridines>, Application of C6H6ClNO2S, the main research area is isocyanoethyl indole aziridine dysprosium catalyst enantioselective tandem reaction; phenyltetrahydropyrrolo pyridoindole dicarboxylate preparation.

Herein, a tailored strategy to access such compounds through an asym. ring-opening/Friedel-Crafts/Mannich/desulfonylation cascade reaction was reported. In the presence of the N,N’-dioxide-Dy(III) complex, various 2,2′-diester aziridines and 3-(2-isocyanoethyl)indoles were converted into tetracyclic spiroindolines in a highly diastereo- and enantioselective manner (41 examples, up to 88% yield, 97% ee). On the basis of the absolute configuration of the product and previous works, a possible catalytic cycle was proposed to understand the origin of stereocontrol.

Organic Chemistry Frontiers published new progress about Aziridines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application of C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Youcan; Yin, Zhiping; Wu, Xiao-Feng published the artcile< Copper-catalyzed carbonylative synthesis of β-homoprolines from N-fluoro-sulfonamides>, Application In Synthesis of 6961-82-6, the main research area is amino acid homoproline synthesis solvent effect; fluoro sulfonamide carbonylation copper catalyst; carbonylation mechanism intramol cyclization free carbon radical.

A new methodol. for the carbonylative transformation of N-fluoro-sulfonamides into N-sulfonyl-β-homoproline esters has been described. In the presence of a catalytic amount of Cu(OTf)2, a range of β-homoproline derivatives were prepared in moderate to good yield. The reaction proceeds via the intramol. cyclization and intermol. carbonylation of a free carbon radical. Notably, this procedure offers the possibility to build potential functionalized bioactive mols.

Organic Letters published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hou, Hongcen; Zhao, Yongli; Sheng, Shouri; Chen, Junmin published the artcile< Iridium-Catalyzed ortho-C-H Amidation of Benzenesulfonamides with Sulfonyl Azides>, Safety of o-Chlorobenzenesulfonamide, the main research area is aminobenzesulfonamide preparation regioselective; benzenesulfonamide sulfonyl azide amidation iridium catalyst.

An iridium-catalyzed direct C-H activation/C-N bond formation reaction of benzenesulfonamides RS(O)2NHR1 (R = Ph, 2-methyl-4-fluorophenyl, 3-chlorophenyl, etc.) with sulfonyl azides R2C6H4S(O)2N3 (R2 = H, 4-Me, 2-Me, 4-OMe) was developed. The amidation reaction provides a protocol for the synthesis of 2-aminobenzenesulfonamides I (R3 = H, 2-Me-4-F, 3-Cl, 4-Ph, etc.) in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant-free conditions and only releases mol. nitrogen as the sole byproduct. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided.

Advanced Synthesis & Catalysis published new progress about Amidation (C-H, regioselective). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Safety of o-Chlorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alhamd, Mehdi; Tabatabaie, Tayebeh; Parseh, Iman; Amiri, Fazel; Mengelizadeh, Nezamaddin published the artcile< Magnetic CuNiFe2O4 nanoparticles loaded on multi-walled carbon nanotubes as a novel catalyst for peroxymonosulfate activation and degradation of reactive black 5>, COA of Formula: C6H6ClNO2S, the main research area is copper nickel ferrite carbon nanotube reactive black catalytic degradation; By-products; Degradation pathways; MWCNTs-CuNiFe2O4; Peroxymonosulfate; Real wastewater.

Novel copper-nickel ferrite nanocatalyst loaded on multi-walled carbon nanotube (MWCNTs-CuNiFe2O4) was synthesized and applied to activate peroxymonosulfate (PMS) in the degradation of the reactive black 5 (RB5). The structure of the catalyst was well characterized by scanning electron microscope (SEM), Fourier-transform IR spectroscopy (FTIR), and X-ray powder diffraction (XRD). The MWCNTs-CuNiFe2O4/PMS system showed a high performance in the degradation of RB5 with a kinetic rate of 1.5-2.5 times higher than homogeneous and heterogeneous systems. Maximum degradation efficiency (99.60%) was obtained at an initial pH of 7, catalyst dosage of 250 mg/L, PMS dosage of 4 mM, the temperature of 25°C, and reaction time of 15 min. Anion experiments emphasized that the presence of nitrate, carbonate, and phosphate in the solution reduced the degradation efficiency by producing reactive species with low oxidation potential. The RB5 degradation rate evolved with temperature, and the activation energy was obtained to be 44.48 kJ/mol. The mechanism of PMS activation and production of free radicals was proposed based on tert-Bu alc. (TBA), ethanol (EtOH), and potassium iodide (KI) scavengers. Trapping experiments showed that both sulfate (SO4·-) and hydroxyl (·OH) radicals are involved in the catalytic degradation of RB5. The effective treatment of real wastewater and tap water by the MWCNTs-CuNiFe2O4/PMS system requires a long reaction time. Gas chromatog.-mass spectrometry (GC-MS) anal. indicated that RB5 can be degraded via methylation, decarboxylation, hydroxylation, and ring/chain cleavage pathways. The stable catalytic activity after three consecutive cycles suggested that MWCNTs-CuFe2O4 is a novel reusability catalyst in PMS activation. Graphical abstract: [graphic not available: see fulltext].

Environmental Science and Pollution Research published new progress about Activation energy. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, COA of Formula: C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hou, Hongcen; Zhao, Yongli; Pu, Shouzhi; Chen, Junmin published the artcile< Rhodium-catalyzed direct C-H bond alkynylation of aryl sulfonamides with bromoalkynes>, Application of C6H6ClNO2S, the main research area is alkynyl benzenesulfonamide preparation; aryl sulfonamide bromoalkyne mono alkynylation rhodium catalyst; benzosultam preparation; bromoalkyne aryl sulfonamide alkynylation intramol cyclization cascade rhodium catalyst.

An efficient protocol for the synthesis of ortho-(1-alkynyl)benzenesulfonamides I [R = H, 4-Me, 4-OCF3, etc.] was developed via rhodium-catalyzed direct ortho-mono-alkynylation of aryl sulfonamides with triisopropylsilyl (TIPS)-substituted bromoalkyne. While triethylsilyl or trimethylsilyl (TES or TMS)-substituted bromoalkyne was also amenable to the alkynylation, affording six membered benzosultams II [R1 = TMS, TES; R2 = H, 6-Me, 6-Et, 6-OMe] via the alkynylation/intramol. cyclization cascade reaction. The present protocol displayed high functional group tolerance and broad substrate scope under an air atm. in good to high yields. Mechanistic studies indicated that the reaction proceeded by a turnover limiting C-H activation step and a plausible mechanism was proposed.

Organic & Biomolecular Chemistry published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application of C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics