69065-91-4, These common heterocyclic compound, 69065-91-4, name is Ethyl 2-((4-fluorophenyl)amino)-2-oxoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 1.1 g (5 mmol) of amine 1 and 5 mmol of anilido ester 6a-6f was heated for 5 h at 120-125C. The resulting solid was treated with hexane, and the precipitate was filtered off, washed with water, 10% aqueous HCl, and water again, dried in air, and recrystallized from ethanol.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 69065-91-4.
Reference:
Article; Aghekyan; Mkryan; Muradyan; Tumajyan; Russian Journal of Organic Chemistry; vol. 54; 6; (2018); p. 886 – 891; Zh. Org. Khim.; vol. 54; 6; (2018); p. 884 – 889,6;,
Amide – Wikipedia,
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