Category: 6873-44-5

Reference of 6873-44-5, The chemical industry reduces the impact on the environment during synthesis 6873-44-5, name is 4-Chloro-N-methylbenzamide, I believe this compound will play a more active role in future production and life.

General procedure: Methacryloyl chloride (2 equiv.) was added to a mixture of amide (1 equiv.), triethylamine (2 equiv.) and DMAP (0.1 equiv.) in dichloromethane (20 mL). The resulted mixture was stirred at 35 oC for 10-12 h. The reaction was quenched with saturated aqueous Na2CO3 (5 mL), and then the mixture was extracted with dichloromethane (3 x 5 mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate as the eluent) affording the corresponding N-alkyl-N-methacryloyl benzamides 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-N-methylbenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chen, Yu-Jue; He, Yan-Hong; Guan, Zhi; Tetrahedron; vol. 75; 22; (2019); p. 3053 – 3061;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6873-44-5, name is 4-Chloro-N-methylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 6873-44-5

EXAMPLE IV N-Methyl 4-Chlorobenzimidoyl Chloride N-Methyl 4-chlorobenzamide (42.6 g, 251 mmole) and thionyl chloride (153.3 g, 1.28 mole) were reacted as in Example I to yield 39.3 g (83.4%) of the title compound, b.p. 125 C. (15 mm Hg).

The synthetic route of 6873-44-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; McNeilab, Inc.; US4528382; (1985); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics