Synthetic Route of 68621-88-5, These common heterocyclic compound, 68621-88-5, name is tert-Butyl (3-aminophenyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(3-Aminophenyl)carbamic acid tert-butyl ester (1.0 g) was dissolved in ethyl acetate (30ml) and treated with aqueous formaldehyde (37% wt, 443 mul) and palladium on carbon (10%, 350 mg). The reaction mixture was hydrogen- ated under a balloon of hydrogen overnight at atmospheric pressure. The cata- lyst was removed by filtration through Celite under nitrogen and the volatiles were removed by evaporation. The residue was purified by chromatography using the Biotage system on a 10 g silica cartridge eluting with a mixture of ethyl acetate and cyclohexane (1 :19 increasing to 1 :1) to give (3-methylamino- phenyl)carbamic acid tert-butyl ester (500 mg). LCMS (Method A) Rt 2.45 (M+H+) 2231H NMR (300MHz) (CDCI3) delta 7.2 (t, 1 H) 6.8 (br s, 1H) 6.5 (dd, 1 H) 6.4 (br s, 1 H), 6.3 (dd, 1 H) 3.7 (br s, 1 H) 2.8 (s, 3H) 1.5 (s, 9H)
Statistics shows that tert-Butyl (3-aminophenyl)carbamate is playing an increasingly important role. we look forward to future research findings about 68621-88-5.
Reference:
Patent; BIOTIE THERAPIES CORP.; KORHONEN, Jani; MARJAMAeKI, Anne; NISSINEN, Liisa; PIHLAVISTO, Marjo; WO2010/146236; (2010); A1;,
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