Category: 685-91-6

Matsuura, Akihisa; Ano, Yusuke; Chatani, Naoto published an article in 2022, the title of the article was Nucleophilic aromatic substitution of non-activated aryl fluorides with aliphatic amides.Related Products of 685-91-6 And the article contains the following content:

Nucleophilic aromatic substitution (SNAr) reactions of non-activated aryl fluorides RF [R = (4-biphenyl), [4-(pyridin-2-yl)phenyl], naphthalen-1-yl, pyridin-3-yl, etc.] with amide enolates e.g., 1-methylpyrrolidin-2-one are reported. The reaction proceeds under relatively mild reaction conditions. Lactams also participate in the reaction to give 2-arylated lactams e.g., I. DFT calculations suggest that the reaction proceeds through a concerted SNAr pathway. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6

The Article related to amide preparation, aliphatic amide aryl fluoride nucleophilic aromatic substitution reaction, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Related Products of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 20, 2018, Zhou, Xibing; Zhang, Guoying; Gao, Bao; Huang, Hanmin published an article.Reference of N,N-Diethylacetamide The title of the article was Palladium-Catalyzed Hydrocarbonylative C-N Coupling of Alkenes with Amides. And the article contained the following:

Terminal alkenes such as styrene and norbornene underwent regioselective hydrocarbonylation and acyl metathesis reactions with amides such as DMF using NH4Cl or N-methylpyrrolidine hydrochloride as additive under 10 atm. CO pressure at 120° in the presence of either Pd(Pt-Bu3)2 or Pd(MeCN)2Cl2 and Xantphos to yield amides such as PhCHMeCONMe2 or PhCH2CH2CONMe2, resp. N-alkenylamides underwent intramol. hydrocarbonylation and acyl metathesis reactions to yield lactams. Use of NMP·DCl as additive yielded partially deuterated amides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to amide regioselective preparation, palladium catalyst regioselective hydrocarbonylation metathesis alkene amide, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Iacobucci, Claudio; Jouini, Nedra; Massi, Lionel; Olivero, Sandra; De Angelis, Francesco; Dunach, Elisabet; Gal, Jean-Francois published an article in 2017, the title of the article was Quantitative Ligand Affinity Scales for Metal Triflate Salts: Application to Isomer Differentiation.Synthetic Route of 685-91-6 And the article contains the following content:

Owing to the importance of metal triflates in catalysis, the affinity of the cationic center for a selection of organic ligands was explored for InIII and ZnII triflates. The organic Lewis bases include a variety of carbonyls (amides, unsaturated ketones, a lactone) and cyclic 1,2-diols. The relative affinity of the ligands for the cationic center in triflates was quant. determined on the basis of relative ion concentrations determined by electrospray-ionization mass spectrometry. The affinity scales were discussed with reference to gas-phase proton basicity and Lewis basicity scales. Structural isomers and stereoisomers display significant affinity differences in several cases. In the case of isomer mixtures, a model describing the relative peak intensities in the mass spectra was developed. On this basis, an isomer titration method was set up. Remarkably, this MS-based method overcame the blindness of mass spectrometry to isomers without the need for isotope labeling or MS/MS experiments This model may prove to have applications in anal. chem. and catalysis. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to metal triflate salt isomer differentiation ligand affinity, lewis acids, affinity, isomer recognition, mass spectrometry, metal triflates, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2021, Legacy, Christopher J.; Hope, Taylor O.; Gagne, Yohann; Greenaway, Frederick T.; Frenette, Mathieu; Emmert, Marion H. published an article.SDS of cas: 685-91-6 The title of the article was Mechanistic Insights into Fe Catalyzed α-C-H Oxidations of Tertiary Amines. And the article contained the following:

We report detailed mechanistic investigations of an iron-based catalyst system, which allows the α-C-H oxidation of a wide variety of amines. In contrast to other catalysts that effect α-C-H oxidations of tertiary amines, the system under investigation exclusively employs peroxy esters as oxidants. More common oxidants (e. g. tBuOOH) previously reported to affect amine oxidations via free radical pathways do not provide amine α-C-H oxidation products in combination with the described catalyst system. The investigations described herein employ initial rate kinetics, kinetic profiling, DFT calculations as well as Eyring, kinetic isotope effect, Hammett, ligand coordination, and EPR studies to shed light on the Fe catalyst system. The obtained data suggest that the catalytic mechanism proceeds through C-H abstraction at a coordinated substrate mol. This rate-determining step occurs either through an Fe(IV) oxo pathway or a 2-electron pathway at an Fe(II) intermediate with bound oxidant. DFT calculations indicate that the Fe(IV) oxo mechanism will be the preferred route of these two possibilities. We further show via kinetic profiling and EPR studies that catalyst activation follows a radical pathway, which is initiated by hydrolysis of PhCO3tBu to tBuOOH. Overall, the obtained mechanistic data support a non-classical, Fe catalyzed pathway that requires substrate binding, inducing selectivity for α-C-H functionalization. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6

The Article related to tripropylamine iron oxidation mechanism kinetics hammett constant, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.SDS of cas: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cardenal, Ashley D.; Jeong Park, Hye; Chalker, Cody J.; Ortiz, Kacey G.; Powers, David C. published an article in 2017, the title of the article was cis-Decalin oxidation as a stereochemical probe of in-MOF versus on-MOF catalysis.Recommanded Product: N,N-Diethylacetamide And the article contains the following content:

Development of catalyst-controlled C-H hydroxylation could provide direct access to valuable synthetic targets, such as primary metabolites. Here, we report a new family of porous materials, comprised of 2-dimensional metalloporphyrin layers and flexible aliphatic linkers, and demonstrate C-H hydroxylation activity. We demonstrate that the stereochem. of cis-decalin oxidation provides a useful tool for differentiating catalysis in from catalysis on porous materials, which is critical to leveraging the potential of porous materials for catalyst-controlled oxidation chem. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: N,N-Diethylacetamide

The Article related to metal organic framework porous catalyst hydroxylation stereoselectivity, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Recommanded Product: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2017, Mokhov, V. M.; Butov, G. M.; Saad, K. R. published an article.Formula: C6H13NO The title of the article was Chemical transformations of tetracyclo[3.3.1.13,7.01,3]decane (1,3-dehydroadamantane): II. Reaction of 1,3-dehydroadamantane with N,N-dialkylcarboxamides. And the article contained the following:

Alkylation of N,N-dialkylcarboxamides with 1,3-dehydroadamantane has been accomplished for the first time [e.g., I + N,N-dimethylacetamide → II (59%)]. The reaction involves the C-H bond in the α-position with respect to the carbonyl group and provides a convenient one-step preparation of substituted carboxylic acid amides containing an 1-adamantyl substituent and a pharmacophoric group in the amide moiety. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Formula: C6H13NO

The Article related to alkylation tertiary amide dehydroadamantane, carboxamide adamantyl derivative preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shyamsundar, M.; Shamshuddin, S. Z. Mohamed published an article in 2019, the title of the article was Mo (VI)/ZrO2 coated on honeycomb monolith as solid acid green catalyst for the acetylation of substituted alcohols and amines under solvent free conditions.Synthetic Route of 685-91-6 And the article contains the following content:

Honeycomb (HC) monolith coated with solid acids such as Mo (VI)/ZrO2 (MZ) with different Mo loadings (2, 6 and 10%) have been prepared by wet impregnation method and characterized by NH3 -TPD, BET surface area, PXRD, ICPOES, SEM, TEM and EDAX techniques. These catalysts have been used as for the synthesis of O and N-acetylation reactions by the condensation of various alcs. with acetic anhydride under solvent free conditions in shorter times (20 min) at moderate temperature (70°C). Especially, 6% Mo (VI)/ZrO2 catalysts are found to be highly acidic and also resulted in high yields of O and N acetylated products up to ~99%. This methodol. offers several advantages such as excellent yields, easy procedure, mild and environmentally benign conditions. MZ catalysts are found to be economical, efficient and highly active, recyclable and reusable up to 6 reaction cycles without much loss of their activity. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to molybdenum zirconia coated honeycomb monolith solid acid green catalyst, substituted alc acetylation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 20, 2017, Aruri, Hariprasad; Singh, Umed; Kumar, Mukesh; Sharma, Sumit; Aithagani, Sravan Kumar; Gupta, Vivek K.; Mignani, Serge; Vishwakarma, Ram A.; Singh, Parvinder Pal published an article.Recommanded Product: 685-91-6 The title of the article was Metal-free Cross-Dehydrogenative Coupling of HN-azoles with α-C(sp3)-H Amides via C-H Activation and Its Mechanistic and Application Studies. And the article contained the following:

A metal-free one step coupling reaction between various N-azole rings and diverse α-C(sp3)-H containing amides has been developed under oxidative reaction conditions. Com. available tetrabutylammonium iodide (TBAI) in the presence of tert-Bu hydroperoxide (TBHP), under neat reaction conditions, efficiently catalyzed the coupling. Various azole types, such as 1H-benzotriazoles, 1H-1,2,3-triazoles, 1H-1,2,4-triazoles, 1H-tetrazoles, 1H-pyrazoles, and 1H-benzimidazoles, and α-C(sp3)-H containing amides, such as N,N-dimethylacetamide, N,N-dimethylbenzamide, N-methylacetamide, N,N-diethylacetamide, N-methylpyrrolidine, and pyrrolidin-2-one, were successfully employed for the coupling. A series of designed and controlled experiments were also performed in order to study the involvement of the different intermediates. Based on the evidence, a plausible mechanism is also proposed. These novel, simple, rapid, attractive, and straightforward transformations open the way of the construction of novel highly functionalized N-azoles via direct covalent N-H bond transformations onto N-C bonds. This approach allows to the synthesis of complex mols. requiring number of steps using classical synthetic ways. In addition, the range of α-C(sp3)-H containing amide substrates is virtually unlimited highlighting the potential value of this simple system for the construction of complex heterocyclic mols., such as fused azole derivatives The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: 685-91-6

The Article related to dehydrogenative coupling azole amide, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 21, 2021, Xu, Chang; Shen, Fang-Qi; Feng, Gaofeng; Jin, Jian published an article.COA of Formula: C6H13NO The title of the article was Visible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes. And the article contained the following:

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, was disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in N,N-diethylethanamide in the presence of Cs2CO3 afforded α-arylated amines in good to excellent yields. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).COA of Formula: C6H13NO

The Article related to tertiary amine benzonitrile photochem regioselective arylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Tan, Tian; Cheng, Hongye; Chen, Guzhong; Song, Zhen; Qi, Zhiwen published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Prediction of infinite-dilution activity coefficients with neural collaborative filtering. And the article contained the following:

Accurate prediction of infinite dilution activity coefficient (γ∞) for phase equilibrium and process design is crucial. In this work, an exptl. γ∞ dataset containing 295 solutes and 407 solvents (21,048 points) is obtained through data integrating, cleaning, and filtering. The dataset is arranged as a sparse matrix with solutes and solvents as columns and rows, resp. Neural collaborative filtering (NCF), a modern matrix completion technique based on deep learning, is proposed to fully fill in the γ∞ matrix. Ten-fold cross-validation is performed on the collected dataset to test the effectiveness of the proposed NCF, proving that NCF outperforms the state-of-the-art phys. model and previous machine learning model. The completed γ∞ matrix makes solvent screening and extension of UNIFAC parameters possible. Taking two typical hard-to-sep. systems (benzene/cyclohexane and Me cyclopentane/n-hexane mixtures) as examples, the NCF-developed database provides high-throughput screening for separation systems in terms of solvent selectivity and capacity. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to prediction infinite dilution activity coefficient neural collaborative filtering, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics