683-57-8 Archives - Page 4 of 12 - Amides-buliding-blocks

Perez-Lourido, Paulo’s team published research in Dalton Transactions in 2022 | CAS: 683-57-8

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Category: amides-buliding-blocks

In 2022,Perez-Lourido, Paulo; Madarasi, Eniko; Antal, Fanni; Esteban-Gomez, David; Wang, Gaoji; Angelovski, Goran; Platas-Iglesias, Carlos; Tircso, Gyula; Valencia, Laura published an article in Dalton Transactions. The title of the article was 《Stable and inert macrocyclic cobalt(II) and nickel(II) complexes with paraCEST response》.Category: amides-buliding-blocks The author mentioned the following in the article:

We report the synthesis of the macrocyclic ligands 3,9-PC2AMH (2,2′-(3,6,9-triaza-1(2,6)-pyridinacyclodecaphane-3,9-diyl)diacetamide) and 3,9-PC2AMtBu (2,2′-(3,6,9-triaza-1(2,6)-pyridinacyclodecaphane-3,9-diyl)bis(N-tert-butyl)acetamide) which contain a pyclen platform functionalized with acetamide or tert-butylacetamide pendant arms at positions 3 and 9 of the macrocyclic unit. The corresponding Co(II) and Ni(II) complexes were prepared, isolated and characterized as potential paramagnetic chem. exchange saturation transfer (paraCEST) agents. The X-ray structures of the Ni(II) complexes reveal six-coordination of the ligands to the metal ion. The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water mol. The structure of the Co(II) complexes was investigated using 1H NMR spectroscopy and computational methods. The complexes present a seven-coordinate structure in solution, as demonstrated by the anal. of the paramagnetic shifts using d. functional theory. Ligand protonation constants and stability constants of the complexes with 3,9-PC2AMH were determined using potentiometric titrations (I = 0,15 M NaCl). The Co(II) complex was found to be more stable than the Ni(II) analog (log KCoL = 14.46(5) and log KNiL = 13.15(3)). However, the Ni(II) and Co(II) complexes display similar rate constants characterizing the proton-assisted dissociation mechanism. The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analog at 25°C. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Category: amides-buliding-blocks)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Han, Lu’s team published research in Organic & Biomolecular Chemistry in 2021 | CAS: 683-57-8

Han, Lu; Zhang, Xue-Ting; Xie, Dong; Tian, Shi-Kai published an article in 2021. The article was titled 《Aryne-mediated [2,3]-sigmatropic rearrangement of tertiary 2,3-allenylamines bearing an electron-withdrawing group at the α-position》, and you may find the article in Organic & Biomolecular Chemistry.Product Details of 683-57-8 The information in the text is summarized as follows:

An unprecedented [2,3]-sigmatropic rearrangement reaction of quaternary 2,3-allenylammonium ylides, generated in-situ from tertiary 2,3-allenylamines and arynes, was established. With 2-(trimethylsilyl)aryl triflates as aryne precursors, a range of tertiary 2,3-allenylamines bearing an electron-withdrawing group at the α-position smoothly participated in the aryne-mediated [2,3]-sigmatropic rearrangement at room temperature, delivering structurally diverse 2-vinylallyamines or 1-amino-1,3-dienes in moderate to excellent yields. The reaction proceeded in the absence of strong bases and transition metals, was compatible with moisture and air and tolerated a wide variety of functional groups. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Product Details of 683-57-8)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Lei’s team published research in Journal of Medicinal Chemistry in 2020 | CAS: 683-57-8

《Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Wang, Lei; Jiang, Jingsheng; Zhang, Lixiao; Zhang, Qiuyue; Zhou, Jianrui; Li, Li; Xu, Xiaoli; You, Qidong. Reference of 2-Bromoacetamide The article mentions the following:

Cell division cycle 37 (Cdc37) is known to work as a kinase-specific cochaperone, which selectively regulates the maturation of kinases through protein-protein interaction (PPI) with Hsp90. Directly disrupting the Hsp90-Cdc37 PPI is emerging as an alternative strategy to develop anticancer agents through a specific inhibition manner of kinase clients of Hsp90. Based on a first specific small-mol. inhibitor targeting Hsp90-Cdc37 PPI (DDO-5936), which was previously reported by our group, we conducted a preliminary investigation of the structure-activity relationships and pharmacodynamic evaluations to improve the potency and drug-like properties. Here, our efforts resulted in the currently best inhibitor 18h with improved binding affinity (Kd = 0.5μM) and cellular inhibitory activity (IC50 = 1.73μM). Both in vitro and in vivo assays revealed that 18h could efficiently block the Hsp90-Cdc37 interaction to specifically inhibit kinase clients of Hsp90. Furthermore, 18h showed ideal physiochem. properties with favorable stability, leading to an oral efficacy in vivo. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Reference of 2-Bromoacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bond, Christopher J.’s team published research in Inorganic Chemistry in 2019 | CAS: 683-57-8

In 2019,Inorganic Chemistry included an article by Bond, Christopher J.; Sokolow, Gregory E.; Crawley, Matthew R.; Burns, Patrick J.; Cox, Jordan M.; Mayilmurugan, Ramasamy; Morrow, Janet R.. Safety of 2-Bromoacetamide. The article was titled 《Exploring Inner-Sphere Water Interactions of Fe(II) and Co(II) Complexes of 12-Membered Macrocycles To Develop CEST MRI Probes》. The information in the text is summarized as follows:

Several paramagnetic Co(II) and Fe(II) macrocyclic complexes were prepared with the goal of introducing a bound H2O ligand to produce paramagnetically shifted H2O 1H resonances and for paramagnetic chem. exchange saturation transfer (paraCEST) applications. Three 12-membered macrocycles with amide pendent groups including 1,7-bis(carbamoylmethyl)-1,4,7,10-tetraazacyclodocane (DCMC), 4,7,10-tris(carbamoylmethyl)-,4,7,10-triaza-12-crown-ether (N3OA), and 4,10-bis(carbamoylmethyl)-4,10-diaza-12-crown-ether (NODA) were prepared and their Co(II) complexes were characterized in the solid state and in solution The crystal structure of [Co(DCMC)]Br2 featured a six-coordinated Co(II) center with distorted octahedral geometry, while [Co(NODA)(OH2)]Cl2 and [Co(N3OA)](NO3)2 were seven-coordinated. The analogous Fe(II) complexes of NODA and NO3A were successfully prepared, but the complex of DCMC oxidized rapidly to the Fe(III) form. Similarly, [Fe(NODA)]2+ oxidized over several days, forming crystals of the Fe(III) complex isolated as the μ-O bridged dimer. Magnetic susceptibility values and paramagnetic NMR spectra of the Fe(II) complexes of NODA and N3OA, as well as Co(II) complexes of DCMC, NODA, and N3OA, were consistent with high spin complexes. CEST peaks ranging from 60 ppm to 70 ppm, attributed to NH groups of the amide pendents, were identified. Variable-temperature 17O NMR spectra of Co(II) and Fe(II) NODA complexes were consistent with rapid exchange of the H2O ligand with bulk H2O. Notably, the Co(II) and Fe(II) complexes presented here produced substantial paramagnetic shifts of bulk H2O 1H resonances, independent of having an inner-sphere H2O. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8Safety of 2-Bromoacetamide) was used in this study.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Guodong’s team published research in Journal of Medicinal Chemistry in 2022 | CAS: 683-57-8

In 2022,Liu, Guodong; Hou, Ruilin; Xu, Lijuan; Zhang, Xinqi; Yan, Jianyu; Xing, Chengguo; Xu, Ke; Zhuang, Chunlin published an article in Journal of Medicinal Chemistry. The title of the article was 《Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides》.Safety of 2-Bromoacetamide The author mentioned the following in the article:

Directly inhibiting the Keap1-Nrf2 protein-protein interaction has been investigated as a promising strategy to activate Nrf2 for anti-inflammation. We previously reported a naphthalensulfonamide Keap1-Nrf2 inhibitor NXPZ-2, but have not determined the exact binding mode with Keap1. This sym. naphthalenesulfonamide compound has relatively low solubility Herein, we first determined a crystal complex (resolution: 2.3 Å) of human Keap1 Kelch domain with NXPZ-2. Further optimizations on the solvent exposed region obtained asym. naphthalenesulfonamides and three crystal structures of Keap1 in complex with designed compounds Among them, the asym. piperazinyl-naphthalenesulfonamide 6k with better aqueous solubility showed the best KD2 value of 0.21μM to block the interaction. The productions of ROS and NO and the expression of TNF-α were inhibited by 6k in the in vitro model. This compound could relieve inflammations by significantly increasing the Nrf2 nuclear translocation in the LPS-induced ALI model with promising pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Safety of 2-Bromoacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sun, Bin’s team published research in Asian Journal of Organic Chemistry in 2021 | CAS: 683-57-8

Sun, Bin; Tang, Xiaoli; Shi, Rongcheng; Yan, Zhiyang; Li, Bingqian; Tang, Chen; Jin, Can; Wu, Chunlei L.; Shen, Runpu P. published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Self-photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer》.Recommanded Product: 2-Bromoacetamide The article contains the following contents:

A mild, external photocatalyst- and additive-free protocol for photo-induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl-substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8Recommanded Product: 2-Bromoacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Jiafu’s team published research in Environmental Science & Technology in 2021 | CAS: 683-57-8

Li, Jiafu; Aziz, Tareq Md.; Granger, Caroline O.; Richardson, Susan D. published their research in Environmental Science & Technology in 2021. The article was titled 《Are Disinfection Byproducts (DBPs) Formed in My Cup of Tea? Regulated, Priority, and Unknown DBPs》.Safety of 2-Bromoacetamide The article contains the following contents:

Globally, tea is the second most consumed nonalcoholic beverage next to drinking water and is an important pathway of disinfection byproduct (DBP) exposure. When boiled tap water is used to brew tea, residual chlorine can produce DBPs by the reaction of chlorine with tea compounds In this study, 60 regulated and priority DBPs were measured in Twinings green tea, Earl Gray tea, and Lipton tea that was brewed using tap water or simulated tap water (nanopure water with chlorine). In many cases, measured DBP levels in tea were lower than in the tap water itself due to volatilization and sorption onto tea leaves. DBPs formed by the reaction of residual chlorine with tea precursors contributed ~12% of total DBPs in real tap water brewed tea, with the remaining 88% introduced by the tap water itself. Of that 12%, dichloroacetic acid, trichloroacetic acid, and chloroform were the only contributing DBPs. Total organic halogen in tea nearly doubled relative to tap water, with 96% of the halogenated DBPs unknown. Much of this unknown total organic halogen (TOX) may be high-mol.-weight haloarom. compounds, formed by the reaction of chlorine with polyphenols present in tea leaves. The identification of 15 haloarom. DBPs using gas chromatog.-high-resolution mass spectrometry indicates that this may be the case. Further studies on the identity and formation of these aromatic DBPs should be conducted since haloarom. DBPs can have significant toxicity.2-Bromoacetamide(cas: 683-57-8Safety of 2-Bromoacetamide) was used in this study.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hao, Guiyun’s team published research in Bioorganic & Medicinal Chemistry in 2021 | CAS: 683-57-8

Hao, Guiyun; Li, Hao; Yang, Fei; Dong, Duoling; Li, Zezhong; Ding, Yingying; Pan, Wei; Wang, Enduo; Liu, Rujuan; Zhou, Huchen published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors》.Formula: C2H4BrNO The article contains the following contents:

1-Hydroxy-2,1-benzoxaboroles I were prepared and examined for inhibitory activity against leucyl-tRNA synthetase (LeuRS) and antibacterial activity against multidrug-resistant S. pneumoniae pathogen. Pneumonia caused by bacterium S. pneumoniae is a severe acute respiratory infectious disease with high morbidity and mortality, especially for children and immunity-compromised patients. The emergence of multidrug-resistant S. pneumoniae also presents a challenge to human health. Leucyl-tRNA synthetase (LeuRS) catalyzes the attachment of L-leucine to tRNALeu, which plays an essential role in protein translation and is considered an attractive antimicrobial drug target. In the present work, benzhydrol-oxaborole hybrid compounds were designed and synthesized as inhibitors of S. pneumoniae LeuRS. Exploration of the Ph ring near Lysine 389 eventually yielded compounds 46 and 54 with submicromolar inhibitory potency. The co-crystal of compound 54 in the editing domain pocket of SpLeuRS was obtained and confirmed the formation of an addnl. hydrogen bond between the carbonyl of 54 and Lysine 389. It also showed anti-pneumococcal activity in vitro. The structure-activity relationship was discussed. This work will provide an essential foundation for the further development of anti-pneumococcal agents by targeting LeuRS. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8Formula: C2H4BrNO)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Molloy, Jennifer K.’s team published research in Supramolecular Chemistry in 2020 | CAS: 683-57-8

《Self-assembled Ln(III) cyclen-based micelles and AuNPs conjugates as candidates for luminescent and magnetic resonance imaging (MRI) agents》 was written by Molloy, Jennifer K.; Nonat, Aline M.; O’Brien, John E.; Brougham, Dermot F.; Gunnlaugsson, Thorfinnur. Formula: C2H4BrNO And the article was included in Supramolecular Chemistry in 2020. The article conveys some information:

The tetra-substituted heptadentate cyclen (1,4,7,10-tetraazacyclododecane) based Eu(III)/Tb(III)/Gd(III)-complexes 1.Ln and 2.Ln were developed. An 1.Eu/Tb and 2.Eu/Tb and were employed in the formation of luminescent self-assembling ternary structures, and we demonstrate that only in the presence of appropriate sensitizing antennae, was the lanthanide-emission of 1.Eu/Tb and 2.Eu/Tb ‘switched on’. An 1.Gd/2.Gd were developed as potential MIR contrast agents, and employed in NMRD-measurements, where their relaxivity was investigated, and their (relatively high) r1 values determined The formation of a self-assembled micelle-type structure was clearly observed for 2.Gd. The functionalised gold nanoparticles 1.Ln-AuNP were also synthesized from 1.Ln. As for the free complexes, the Ln-emission was ‘switched on’ for 1.Eu/Tb-AuNP in the presence of the antennae. NMRD measurements indicated that the relaxivity for the 1.Gd-AuNP systems was very high, with a value of 445 s-1mM-1 (at 400 MHz), demonstrating the cumulative effect of the relatively high number of 1.Gd complexes on the surface of the AuNP. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Formula: C2H4BrNO)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pradhan, Rabindra N.’s team published research in Inorganica Chimica Acta in 2019 | CAS: 683-57-8

In 2019,Inorganica Chimica Acta included an article by Pradhan, Rabindra N.; Hossain, Sayed M.; Lakma, Avinash; Stojkov, Dragana D.; Verbic, Tatjana Z.; Angelovski, Goran; Pujales-Paradela, Rosa; Platas-Iglesias, Carlos; Singh, Akhilesh K.. Name: 2-Bromoacetamide. The article was titled 《Water soluble Eu(III) complexes of macrocyclic triamide ligands: Structure, stability, luminescence and redox properties》. The information in the text is summarized as follows:

Two macrocyclic triamide octadentate chelator scaffolds L1 and L2 were synthesized, characterized by several spectroscopic techniques, and their pKa values were determined by potentiometric titration Using these ligands, two water soluble paramagnetic Eu(III) complexes, [EuL1(OH2)](NO3)3·H2O (EuL1) and [EuL2(OH2)](NO3)3·H2O (EuL2) were synthesized and characterized in the solid state and in solution Single crystal x-ray diffraction measurement of [EuL1(OH2)](NO3)3. H2O (EuL1) reveals octadentate binding of the ligand to Eu(III) and ninth coordination being completed by an O atom of a solvent mol. (H2O). X-ray diffraction data of [EuL2(OH2)](NO3)3·H2O (EuL2) were severely disordered and hence its chloride analog [EuL2(DMF)]Cl3·H2O·MeOH (EuL2-Cl) was synthesized and characterized using single-crystal x-ray diffraction measurements. The crystal data of [EuL2(DMF)](Cl)3·H2O·MeOH (EuL2-Cl) reveal octadentate binding of the ligand to Eu(III), with the ninth coordination being completed by an O atom of a solvent mol. (DMF). Luminescence measurements confirm the presence of a H2O mol. coordinated to Eu(III) in aqueous solution The stability of the Eu(III) complexes was studied using spectrophotometric molar ratio method. Cyclic voltammetry studies obtained from aqueous solutions of the Eu(III) complexes show reversible one electron reduction processes at the glassy C electrode with E1/2 = -0.799 V and -0.777 V (vs. Ag/AgCl) for the complexes of L1 and L2. In the experimental materials used by the author, we found 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics