683-57-8 Archives - Page 2 of 12 - Amides-buliding-blocks

Yu, Meng’s team published research in Dalton Transactions in 2019 | CAS: 683-57-8

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Category: amides-buliding-blocks

The author of 《Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents》 were Yu, Meng; Bouley, Bailey S.; Xie, Da; Que, Emily L.. And the article was published in Dalton Transactions in 2019. Category: amides-buliding-blocks The author mentioned the following in the article:

We reported a set of water-soluble transition metal complexes that can serve as both 19F and PARACEST magnetic resonance imaging agents. The high number of equivalent fluorine atoms and the paramagnetic effect of metals offer these complexes high 19F sensitivity as demonstrated by in vitro19F MRI experiments The complexes contain carboxamide groups appended onto a cyclen macrocycle, which provide 1H CEST peaks well differentiated from bulk water. The Co(II) agent displays two CEST peaks that can be utilized for ratiometric pH determination and the concept of combining 19F MR and PARACEST as complementary imaging techniques was demonstrated with the Fe(II) complex.2-Bromoacetamide(cas: 683-57-8Category: amides-buliding-blocks) was used in this study.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kong, Minjian’s team published research in ChemistrySelect in 2021 | CAS: 683-57-8

Kong, Minjian; Meng, Yan; Fan, Lei; Yin, Chengxian; Chen, Qibin; Liu, Honglai published an article in 2021. The article was titled 《Experimental Study of Poly(1-Acetamide-3-vinylimidazolium Bromide) as a Corrosion Inhibitor for N80 Carbon Steel in HCl》, and you may find the article in ChemistrySelect.HPLC of Formula: 683-57-8 The information in the text is summarized as follows:

A poly(ionic liquid) (PIL), poly(1-acetamide-3-vinylimidazolium bromide) (PCVIB), was investigated as a potential hydrochloric acid corrosion inhibitor for N80 carbon steel (N80-CS) at 25 °C. In this work, the corrosion inhibition properties of PCVIB were monitored using weight loss, potential dynamic polarization (PDP), electrochem. impedance spectroscopy (EIS), SEM (SEM) and XPS. Results show that the maximum inhibition efficiency (IE, η) of PCVIB can reach up to 95.8 %, whereas its monomer only exhibits a low IE of η=33.6 % under the same conditions. Moreover, PCVIB is characteristic of a mixed type inhibitor, which can effectively impede both cathodic hydrogen evolutions and metal dissolution reactions. Addnl., the adsorption of PCVIB on steel surfaces obeys the Langmuir adsorption isotherm. This finding implies that the polymerization can be a viable and facile method to create the high-efficiency inhibitor from monomeric units that were found or used with the poor IE previously. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kubasov, Alexey S.’s team published research in Polyhedron in 2021 | CAS: 683-57-8

Kubasov, Alexey S.; Turyshev, Evgeniy S.; Novikov, Ivan V.; Gurova, Olga M.; Starodubets, Polina A.; Golubev, Aleksei V.; Zhizhin, Konstantin Yu.; Kuznetsov, Nikolay T. published their research in Polyhedron in 2021. The article was titled 《Theoretical and experimental comparison of the reactivity of the sulfanyl-closo-decaborate and sulfanyl-closo-dodecaborate anions and their mono-S-substituted derivatives》.Application In Synthesis of 2-Bromoacetamide The article contains the following contents:

In this work, we have extended the method proposed by Gabel for the preparation of mono- and di-S,S-substituted derivatives of sulfanyl-closo-dodecaborate anion [B12H11SH]2- to derivatives of the closo-decaborate anion. The method is based on the β-elimination of the propionitrile group of sulfonium derivatives [BnHn-1S(R)CH2CH2CN]- in the presence of bases with the formation of the corresponding mono-S-substituted derivatives and acrylonitrile. We also calculated the Fukui functions for the nucleophilic attack of the S-atom in the [B10H9SH]2- and [B12H11SH]2- anions and their mono-S-substituted derivatives using the Hirshfeld approach. As a result, the calculated value of nucleophilicity in the [B10H9SH]2- anion was found to be 5-10 times lower than in other compounds, which completely agrees with the exptl. data. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide) was used in this study.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Perez, Yolanda’s team published research in Pharmaceuticals in 2021 | CAS: 683-57-8

COA of Formula: C2H4BrNOIn 2021 ,《Semaphorin 3A-glycosaminoglycans interaction as therapeutic target for axonal regeneration》 was published in Pharmaceuticals. The article was written by Perez, Yolanda; Bonet, Roman; Corredor, Miriam; Domingo, Cecilia; Moure, Alejandra; Messeguer, Angel; Bujons, Jordi; Alfonso, Ignacio. The article contains the following contents:

Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance mol., inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with Sema3A signaling is proposed as a therapeutic target for achieving functional recovery after CNS injuries. It has been shown that Sema3A adheres to the proteoglycan component of the extracellular matrix (ECM) and selectively binds to heparin and chondroitin sulfate-E (CS-E) glycosaminoglycans (GAGs). We hypothesize that the biol. relevant interaction between Sema3A and GAGs takes place at Sema3A C-terminal polybasic region (SCT). The aims of this study were to characterize the interaction of the whole Sema3A C-terminal polybasic region (Sema3A 725-771) with GAGs and to investigate the disruption of this interaction by small mols. Recombinant Sema3A basic domain was produced and we used a combination of biophys. techniques (NMR, SPR, and heparin affinity chromatog.) to gain insight into the interaction of the Sema3A C-terminal domain with GAGs. The results demonstrate that SCT is an intrinsically disordered region, which confirms that SCT binds to GAGs and helps to identify the specific residues involved in the interaction. NMR studies, supported by mol. dynamics simulations, show that a new peptoid mol. (CSIC02) may disrupt the interaction between SCT and heparin. Our structural study paves the way toward the design of new mols. targeting these protein-GAG interactions with potential therapeutic applications. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8COA of Formula: C2H4BrNO) was used in this study.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Markad, Datta’s team published research in Dalton Transactions in 2019 | CAS: 683-57-8

《Novel primary amide-based cationic metal complexes: green synthesis, crystal structures, Hirshfeld surface analysis and solvent-free cyanosilylation reaction》 was written by Markad, Datta; Khullar, Sadhika; Mandal, Sanjay K.. SDS of cas: 683-57-8This research focused ontransition metal bispyridinylmethyldiacetamideethylene complex preparation thermal stability; crystal structure transition metal bispyridinylmethyldiacetamideethylene complex. The article conveys some information:

A new sym. and flexible primary amide functionalized ligand, 2,2′-(ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))diacetamide (2-BPEG), was synthesized and structurally characterized. Using this multidentate ligand, four novel metal complexes, [Cu(2-BPEG)](ClO4)2·0.5H2O (1), [Zn(2-BPEG)](ClO4)2 (2), [Zn(2-BPEG)](ZnCl4)·H2O (3) and [Cd(2-BPEG)(H2O)](ClO4)2·H2O (4), were synthesized under ambient conditions and characterized by elemental, spectroscopic and thermal anal., and single and powder x-ray diffraction. Complexes 1-3 are hexacoordinated with an N4O2 donor set (provided by the hexadentate 2-BPEG ligand), while complex 4 is heptacoordinated with an addnl. coordinated water mol. In all cases, the 2-BPEG ligand acts as a hexadentate ligand. A change in the starting metal salt gave 2 and 3 with different tetrahedral anions, ClO4- and ZnCl4-, resp. This provided an opportunity to showcase anion-directed supramol. networks for these compounds Compounds 1, 2 and 4 with perchlorate anions show similar and comparable intermol. interactions in their 3-dimensional networks. However, the supramol. self-assembly of 3 is dominated by a variety of intermol. interactions such as C-H···Cl, N-H···Cl, O-H···Cl and C-H···O due to the presence of a tetrachlorozincate(II) ion. Also, the role of weak intermol. interactions in the crystal packing was analyzed and quantified using Hirshfeld surface anal. Also, compound 4 exhibiting an open Lewis acid site is a very efficient and recyclable heterogeneous catalyst for the solvent-free cyanosilylation of various aldehydes with trimethylsilyl cyanide (TMSCN) producing the corresponding trimethylsilyl ether in high yields. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8SDS of cas: 683-57-8)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ingham, Aidan’s team published research in Inorganic Chemistry in 2022 | CAS: 683-57-8

In 2022,Ingham, Aidan; Wharton, Luke; El Sayed, Tarek; Southcott, Lily; McNeil, Brooke L.; Ezhova, Maria B.; Patrick, Brian O.; Jaraquemada-Pelaez, Maria de Guadalupe; Orvig, Chris published an article in Inorganic Chemistry. The title of the article was 《H2ampa-Versatile Chelator for [203Pb]Pb2+, [213Bi]Bi3+, and [225Ac]Ac3+》.Recommanded Product: 683-57-8 The author mentioned the following in the article:

A new decadentate chelator, H2ampa, was designed to be a potential radiopharmaceutical chelator component. The chelator involves both amide and picolinate functional groups on a large non-macrocyclic, ether-bridged backbone. With its large scaffold, H2ampa was paired with [nat/203Pb]Pb2+, [nat/213Bi]Bi3+, and natLa3+/[225Ac]Ac3+ ions. NMR spectroscopy and high-resolution mass spectrometry were used to study the non-radioactive metal complexes. A single crystal of [Bi(ampa)](NO3) was obtained; its asym., 10-coordinate complex structure was revealed by X-ray diffraction. Optimal conformations of the metal complexes were assessed by d. functional theory studies to provide further structural information. Solution studies providing thermodn. insights into metal complex formation revealed H2ampa coordinated Bi3+, Pb2+, and La3+ ions to obtain pM values of 26, 14.8, and 15.1, resp. Preliminary concentration-dependent radiolabeling experiments were carried out between H2ampa and three different radiometals to evaluate their compatibility for radiopharmaceutical applications. The chelator radiolabeled [203Pb]Pb2+, [213Bi]Bi3+, and [225Ac]Ac3+ in short reaction times (7-30 min), at dilute concentrations, and under mild conditions. Thus, H2ampa was proven to be a versatile chelator able to well coordinate a small range of radiometals frequently considered to be alpha therapeutic candidates.2-Bromoacetamide(cas: 683-57-8Recommanded Product: 683-57-8) was used in this study.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ingham, Aidan’s team published research in Dalton Transactions in 2021 | CAS: 683-57-8

Ingham, Aidan; Kostelnik, Thomas I.; McNeil, Brooke L.; Patrick, Brian O.; Choudhary, Neha; Jaraquemada-Pelaez, Maria de Guadalupe; Orvig, Chris published their research in Dalton Transactions in 2021. The article was titled 《Getting a lead on Pb2+-amide chelators for 203/212Pb radiopharmaceuticals》.Computed Properties of C2H4BrNO The article contains the following contents:

Amide-based chelators DTPAm, EGTAm and ampam were synthesized to investigate which chelator most ideally coordinates [nat/203Pb]Pb2+ ions for potential radiopharmaceutical applications. 1H NMR spectroscopy was used to study each metal-ligand complex in the solution state. The 1H NMR spectrum of [Pb(DTPAm)]2+ revealed minimal isomerization and fluxional behavior compared to [Pb(EGTAm)]2+ and [Pb(ampam)]2+, both of which showed fewer spectral changes indicative of less static behavior. The solid-state coordination properties of each complex were also examined from single crystal structures that were studied by X-ray diffraction (XRD). In the solid-state, octadentate DTPAm coordinated Pb2+ to form an eight-coordinate hemidirected complex; octadentate EGTAm coordinated Pb2+ forming a ten-coordinate holodirected complex with a bidentate NO3- ion also coordinated to the metal center; decadentate ampam completely encapsulated the Pb2+ ion to form a ten-coordinate holodirected complex with a C2 axis of symmetry. Potentiometric titrations were carried out to assess the thermodn. stability of each metal-ligand complex. The pM values obtained for [Pb(DTPAm)]2+, [Pb(EGTAm)]2+ and [Pb(ampam)]2+ were 9.7, 7.2 and 10.2, resp. The affinity of each chelator for Pb2+ ions was tested by [203Pb]Pb2+ radiolabeling studies to evaluate their prospects as chelators for [203/212Pb]Pb2+-based radiopharmaceuticals. DTPAm radiolabeled [203Pb]Pb2+ ions achieving molar activities as high as 3.5 MBq μmol-1 within 15 min, at 25°C, whereas EGTAm and ampam produced lower molar activities of 0.25 MBq μmol-1 within 30 min, at 37°C. EGTAm and ampam were therefore deemed unsuitable for [203/212Pb]Pb2+-based radiopharmaceutical applications, while DTPAm warrants further studies. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Computed Properties of C2H4BrNO)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zafon, Elisenda’s team published research in Dalton Transactions in 2022 | CAS: 683-57-8

In 2022,Zafon, Elisenda; Echevarria, Igor; Barrabes, Silvia; Manzano, Blanca R.; Jalon, Felix A.; Rodriguez, Ana M.; Massaguer, Anna; Espino, Gustavo published an article in Dalton Transactions. The title of the article was 《Photodynamic therapy with mitochondria-targeted biscyclometallated Ir(III) complexes. Multi-action mechanism and strong influence of the cyclometallating ligand》.Formula: C2H4BrNO The author mentioned the following in the article:

Photodynamic therapy is an alternative to classical chemotherapy due to its potential to reduce side effects by a controlled activation of a photosensitizer through local irradiation with light. The photosensitizer then interacts with oxygen and generates reactive oxygen species. Iridium biscyclometallated complexes are very promising photosensitizers due to their exceptional photophys. properties and their ability to target mitochondria. Four Ir(III) biscyclometallated complexes of formula [Ir(C^N)2(N^N′)]Cl, where N^N′ is a ligand containing a benzimidazolyl fragment, have been synthesized and characterized. The C^N ligands were 2-phenylpyridinate (ppy) and 2-(2,4-difluorophenyl)pyridinate (dfppy). The complexes exhibited high photostability. The electrochem. and photophys. properties were modulated by both the cyclometallating and the ancillary ligands. The dfppy derivatives yielded the highest emission energy values, quantum yields of phosphorescence and excited state lifetimes. All complexes generated 1O2 in aerated solutions upon irradiation Biol. studies revealed that these complexes have a moderate cytotoxicity in the dark against different human cancer cell lines: prostate (PC-3), colon (CACO-2) and melanoma (SK-MEL-28), and against non-malignant fibroblasts (CCD-18Co). However, derivatives with ppy ligands ([1a]Cl, [2a]Cl) yielded a relevant photodynamic activity upon light irradiation (450 nm, 24.1 J cm-2), with phototoxicity indexes (EC50,dark/EC50,light) of 20.8 and 17.3, resp., achieved in PC-3 cells. Mechanistic studies showed that these complexes are taken up by the cells through endocytosis and preferentially accumulate in mitochondria. Upon photoactivation, the complexes induced mitochondrial membrane depolarization and DNA damage, thus triggering cell death, mainly by apoptosis. Complex [1a]Cl is also able to oxidize NADH. This mitochondria-targeted photodynamic mechanism greatly inhibited the reproductive capacity of cancer cells and provides a valuable alternative to traditional chemotherapy for the controlled treatment of cancer.2-Bromoacetamide(cas: 683-57-8Formula: C2H4BrNO) was used in this study.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Castro, Goretti’s team published research in Inorganic Chemistry in 2021 | CAS: 683-57-8

Castro, Goretti; Wang, Gaoji; Gambino, Tanja; Esteban-Gomez, David; Valencia, Laura; Angelovski, Goran; Platas-Iglesias, Carlos; Perez-Lourido, Paulo published an article in 2021. The article was titled 《Lanthanide(III) Complexes Based on an 18-Membered Macrocycle Containing Acetamide Pendants. Structural Characterization and paraCEST Properties》, and you may find the article in Inorganic Chemistry.HPLC of Formula: 683-57-8 The information in the text is summarized as follows:

We report a detailed investigation of the coordination properties of macrocyclic lanthanide complexes containing a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane scaffold functionalized with four acetamide pendant arms. The X-ray structures of the complexes with the large Ln3+ ions (La and Sm) display 12- and 10-coordinated metal ions, where the coordination sphere is fulfilled by the six N atoms of the macrocycle, the four O atoms of the acetamide pendants, and a bidentate nitrate anion in the La3+ complex. The analogous Yb3+ complex presents, however, a 9-coordinated metal ion because one of the acetamide pendant arms remains uncoordinated. 1H NMR studies indicate that the 10-coordinated form is present in solution throughout the lanthanide series from La to Tb, while the smaller lanthanides form 9-coordinated species. 1H and 89Y NMR studies confirm the presence of this structural change because the two species are present in solution Anal. of the 1H chem. shifts observed for the Tb3+ complex confirms its D2 symmetry in aqueous solution and evidences a highly rhombic magnetic susceptibility tensor. The acetamide resonances of the Pr3+ and Tb3+ complexes provided sizable paraCEST effects, as demonstrated by the corresponding Z-spectra recorded at different temperatures and studies on tube phantoms recorded at 22°C. A 10-coordinated Tb3+ complex shows remarkably a chem. exchange saturation transfer response with a temperature-sensitive chem. shift. In the experimental materials used by the author, we found 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ratanaphain, Chatkrita’s team published research in Chemosphere in 2022 | CAS: 683-57-8

Computed Properties of C2H4BrNOIn 2022 ,《Reactivity characterization of SiO2-coated nano zero-valent iron for iodoacetamide degradation: The effects of SiO2 thickness, and the roles of dehalogenation, hydrolysis and adsorption》 was published in Chemosphere. The article was written by Ratanaphain, Chatkrita; Viboonratanasri, Duangkamon; Prompinit, Panida; Krajangpan, Sita; Khan, Eakalak; Punyapalakul, Patiparn. The article contains the following contents:

The effect of SiO2-layer thickness in SiO2-coated nano zero-valent iron (nZVI) particles on the reactivity characteristics of iodoacetamide (IAcAm) degradation was evaluated. SiO2-layer thicknesses ranging from 3.6 to 27.3 nm were obtained through varying tetra-Et orthosilicate dosages of 0.001-1 M. The crystallinity, surface chem. composition, and physicochem. properties were evaluated for their effects on synergetic degradation mechanisms, dehalogenation, hydrolysis, and adsorption. At a thickness of 3.6 nm, the SiO2 layer offered the highest observed pseudo-first-order rate (kobs) and higher rates of IAcAm degradation were maintained under pH fluctuations (pH 5-7) and aerobic conditions compared to pristine nZVI. At this SiO2-layer thickness (3.6 nm), the rate of iron oxide-layer formation was reduced and the migration of reactive iron species (Fe0 and Fe2+) for the dehalogenation and hydrolysis reactions was enabled. In a single-solute solution, IAcAm elimination was greater than bromoacetamide and chloroacetamide elimination due to the weak ionic I-C bond. In mixed solute conditions, the hydrophobicity of chloroacetamide played a more significant role in competitive degradation through greater adsorption. The proportion of dehalogenation relative to hydrolysis during IAcAm degradation by pristine nZVI and SiO2-coated nZVI was approx. 0.6:0.4. Iodoacetic acid and acetic acid were detected as intermediates in the degradation pathway of IAcAm by pristine nZVI. In contrast, the SiO2 layer on nZVI can accelerate the transformation of IAcAm to acetamide and iodoacetic acid. The electrolyte background of tap water exhibited a slight inhibitory effect on the degradation of IAcAm for both nZVI and SiO2-coated nZVI. The results came from multiple reactions, including the reaction of 2-Bromoacetamide(cas: 683-57-8Computed Properties of C2H4BrNO)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics