Category: 683-57-8

In 2022,Hu, Jun; Qu, Jiajia; Deng, Lin; Dong, Huiyu; Jiang, Liying; Yu, Jianming; Yue, Siqing; Qian, Haifeng; Dai, Qizhou; Qiang, Zhimin published an article in Water Research. The title of the article was 《Metabonomic and transcriptomic modulations of HepG2 cells induced by the CuO-catalyzed formation of disinfection byproducts from biofilm extracellular polymeric substances in copper pipes》.Name: 2-Bromoacetamide The author mentioned the following in the article:

Cupric oxide (CuO) is able to catalyze the reactions among disinfectant, extracellular polymeric substances (EPS) and bromide (Br-) in copper pipes, which may deteriorate the water quality. This study aimed to investigate the metabonomic and transcriptomic modulations of HepG2 cells caused by the CuO-catalyzed formation of disinfection byproducts (DBPs) from EPS. The presence of CuO favored the substitution reactions of chlorine and bromine with EPS, inducing a higher content of total organic halogen (TOX). In addition, DBPs were shifted from chlorinated species to brominated species. A total of 182 differential metabolites (DMs) and 437 differentially expressed genes (DEGs) were identified, which were jointly involved in 38 KEGG pathways. Topol. anal. indicates that glycerophospholipid and purine metabolism were disturbed most obviously. During glycerophospholipid metabolism, the differential expression of genes GPATs, AGPATs, LPINs and DGKs impacted the conversion of glycerol-3-phosphate to 2-diacyl-sn-glycerol, which further affected the conversion among phosphatidylcholine, phosphatidylserine and phosphocholines. During purine metabolism, it was mainly the differential expression of genes POLRs, RPAs, RPBs, RPCs, ENTPDs and CDs that impacted the transformation of RNA into guanine-, xanthosine-, inosine- and adenosine monophosphate, which were further successively transformed into their corresponding nucleosides and purines. The study provides an omics perspective to assess the potential adverse effects of overall DBPs formed in copper pipes on human. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Mutlu, Adem; Yesil, Tamer; Kymaz, Deniz; Zafer, Ceylan published an article in ACS Omega. The title of the article was 《Simultaneous optimization of charge transport properties in a triple-cation perovskite layer and triple-cation perovskite/Spiro-OMeTAD interface by dual passivation》.COA of Formula: C2H4BrNO The author mentioned the following in the article:

Mol. engineering of additives is a highly effective method to increase the efficiency of perovskite solar cells by reducing trap states and charge carrier barriers in bulk and on the thin film surface. In particular, the elimination of undercoordinated lead species that act as the nonradiative charge recombination center or contain defects that may limit interfacial charge transfer is critical for producing a highly efficient triple-cation perovskite solar cell. Here, 2-iodoacetamide (2I-Ac), 2-bromoacetamide (2Br-Ac), and 2-chloroacetamide (2Cl-Ac) mols., which can be coordinated with lead, have been used by adding them into a chlorobenzene antisolvent to eliminate the defects encountered in the triple-cation perovskite thin film. The passivation process has been carried out with the coordination between the oxygen anion (-) and the lead (+2) cation on the enolate mol., which is in the resonance structure of the mols. The Spiro-OMeTAD/triple-cation perovskite interface has been improved by surface passivation by releasing HX (X = I, Br) as a byproduct because of the separation of alpha hydrogen on the mol. As a result, a solar cell with a negligible hysteresis operating at 19.5% efficiency has been produced by using the 2Br-Ac mol., compared to the 17.6% efficiency of the reference cell. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8COA of Formula: C2H4BrNO)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.COA of Formula: C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Exploring Pairwise Chemical Crosslinking To Study Peptide-Receptor Interactions》 were Seidel, Lisa; Zarzycka, Barbara; Katritch, Vsevolod; Coin, Irene. And the article was published in ChemBioChem in 2019. Category: amides-buliding-blocks The author mentioned the following in the article:

Pairwise crosslinking is a powerful technique to characterize interactions between G protein coupled receptors and their ligands in the live cell. In this work, the “”thiol trapping”” method, which exploits the proximity-enhanced reaction between haloacetamides and cysteine, is examined to identify intermol. pairs of vicinal positions. By incorporating cysteine into the corticotropin-releasing factor receptor and either a-chloro- or a-bromoacetamide groups into its ligands, it is shown that thiol trapping provides highly reproducible signals and a low background, and represents a valid alternative to classical “”disulfide trapping””. The method is advantageous if reducing agents are required during sample anal. Moreover, it can provide partially distinct spatial constraints, thus giving access to a wider dataset for mol. modeling. Finally, by applying recombinant mini-Gs, GTPS, and Gas-depleted HEK293 cells to modulate Gs coupling, it is shown that yields of crosslinking increase in the presence of elevated levels of Gs. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Category: amides-buliding-blocks)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays》 was written by Kim, Da-Hye; Park, Chang Gyun; Kim, Young Jun. Application In Synthesis of 2-Bromoacetamide And the article was included in Chemosphere in 2020. The article conveys some information:

Exposure to disinfection byproducts (DBPs) is potentially related to cytotoxic, genotoxic, mutagenic, and tumorigenic effects in humans, in addition to their adverse effects on the environment. However, their impacts on endocrine disruption, especially reproductive toxicity, remain largely unknown. In this study, the estrogenic and androgenic activities of DBPs and corresponding antagonistic activities were investigated using a yeast-based reporter assay, focusing on haloacetic acids and haloacetamides. We also examined the cytotoxicity of DBPs and mechanisms of antagonistic activities. Of the DBPs assayed, iodoacetamide (IAM) and bromoacetamide (BAM) were the most cytotoxic, with LC50 values of 0.0462 and 0.0537 mM, resp., followed by chloroacetic acid (CAA; LC50 = 4.87 mM) and chloroacetamide (CAM; LC50 = 5.28 mM). Iodoacetic acid (IAA) and bromoacetic acid (BAA) were the least cytotoxic, with LC50 values of 5.52 and 6.35 mM, resp. IAA (EC10 = 0.00573 mM; EC50 = 0.0215 mM) exhibited most potent estrogenic activity, and CAA (EC10 = 0.0434 mM) and BAM (EC10 = 0.0150 mM) showed weak estrogenic and androgenic activities, resp. By contrast, IAM exhibited anti-estrogenic effects. These results suggest that DBPs interact with hormone receptors. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application In Synthesis of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Chemical synthesis of transactivation domain (TAD) of tumor suppressor protein p53 by native chemical ligation of three peptide segments》 was written by Baral, Abhishek; Asokan, Aromal; Bauer, Valentin; Kieffer, Bruno; Torbeev, Vladimir. Safety of 2-BromoacetamideThis research focused ontransactivation domain tumor suppressor protein p53 total synthesis NMR; solid phase peptide synthesis thioesterification native chem ligation alkylation; post translational modification protein folding binding NCBD conformation CD; NCBD nuclear coactivator binding domain CREB binding protein. The article conveys some information:

Chem. composition of tumor suppressor protein p53 is altered via multiple post-translational modifications which modulate its cellular lifetime and interactions with other biomols. Here we report total chem. synthesis of a 61-residue form of transactivation domain (TAD) of p53 based on native chem. ligation of three peptide segments. The experiments to characterize its binding to nuclear co-activator binding domain (NCBD) of CREB-binding protein confirmed native-like induced folding upon binding to NCBD. Thus, the synthetic approach described herein can be useful for the preparation of various post-translationally modified analogs of TAD-p53 for further functional biochem. and biophys. studies. The results came from multiple reactions, including the reaction of 2-Bromoacetamide(cas: 683-57-8Safety of 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Safety of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Qian, Yunkun; Chen, Yanan; Hu, Yue; Hanigan, David; Westerhoff, Paul; An, Dong published their research in Water Research in 2021. The article was titled 《Formation and control of C- and N-DBPs during disinfection of filter backwash and sedimentation sludge water in drinking water treatment》.Synthetic Route of C2H4BrNO The article contains the following contents:

Drinking water treatment plants (DWTPs) produce filter backwash water (FBW) and sedimentation sludge water (SSW) that may be partially recycled to the head of DWTPs. The impacts of key disinfection conditions, water quality parameters (e.g., disinfection times, disinfectant types and doses, and pH values), and bromide concentration on controlling the formation of trihalomethanes (THMs), haloacetic acids (HAAs), haloacetonitriles (HANs), and haloacetamides (HAMs) during disinfection of FBW and SSW were investigated. Concentrations of most disinfection byproducts (DBPs) and associated calculated toxicity increased with extended chlorination for both FBW and SSW. During chlorination of both FBW and SSW, elevated chlorine doses significantly increased THM yields per unit dissolved organic carbon (DOC), but decreased HAN and HAM yields, with min. effect on HAA yields. Chloramine disinfection effectively inhibited C-DBP formation but promoted N-DBPs yields, which increased with chloramine dose. Calculated toxicities after chloramination increased with chloramine dose, which was opposite to the trend found after free chlorine addition An examination of pH effects demonstrated that C-DBPs were more readily generated at alk. pH (pH=8), while acidic conditions (pH=6) favored N-DBP formation. Total DBP concentrations increased at higher pH levels, but calculated DBP toxicity deceased due to lower HAN and HAM concentrations Addition of bromide markedly increased bromo-THM and bromo-HAN formation, which are more cytotoxic than chlorinated analogs, but had little impact on the formation of HAAs and HAMs. Bromide incorporation factors (BIFs) for THMs and HANs from both water samples all significantly increased as bromide concentrations increased. Overall, high bromide concentrations increased the calculated toxicity values in FBW and SSW after chlorination. Therefore, while currently challenging, technologies capable of removing bromide should be explored as part of a strategy towards controlling cumulative toxicity burden (i.e., hazard) while simultaneously lowering individual DBP concentrations (i.e., exposure) to manage DBP risks in drinking water. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Synthetic Route of C2H4BrNO)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Synthetic Route of C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Haloacetonitriles and haloacetamides precursors in filter backwash and sedimentation sludge water during drinking water treatment》 was written by Qian, Yunkun; Hu, Yue; Chen, Yanan; An, Dong; Westerhoff, Paul; Hanigan, David; Chu, Wenhai. Formula: C2H4BrNO And the article was included in Water Research in 2020. The article conveys some information:

Haloacetonitriles (HANs) and haloacetamides (HAMs) are nitrogenous disinfection byproducts that are present in filter backwash water (FBW) and sedimentation sludge water (SSW). In many cases FBW and SSW are recycled to the head of drinking water treatment plants. HAN and HAM concentrations in FBW and SSW, without addnl. oxidants, ranged from 6.8 to 11.6 nM and 2.9 to 3.6 nM of three HANs and four HAMs, resp. Upon oxidant addition to FBW and SSW under formation potential conditions, concentrations for six HANs and six HAMs ranged from 92.2 to 190.4 nM and 42.2 to 95.5 nM, resp. Therefore, at common FBW and SSW recycle rates (2 to 10% of treated water flows), the precursor levels in these recycle waters should not be ignored because they are comparable to levels present in finished water. Brominated HAN and chlorinated HAM were the dominant species in FBW and SSW, resp. The lowest mol. weight ultrafiltration fraction (< 3 kDa) contributed the most to HAN and HAM formations. The hydrophilic (HPI) organic fraction contributed the greatest to HAN precursors in sand-FBW and SSW and were the most reactive HAM precursors in both sand- or carbon-FBWs. Fluorescence revealed that aromatic protein-like compounds were dominant HAN and HAM precursors. Therefore, strategies that remove low mol. weight hydrophilic organic matter and aromatic protein-like compounds will minimize HAN and HAM formations in recycled FBW and SSW. The experimental process involved the reaction of 2-Bromoacetamide(cas: 683-57-8Formula: C2H4BrNO)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Formula: C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Design of a Primary-Amide-Functionalized Highly Efficient and Recyclable Hydrogen-Bond-Donating Heterogeneous Catalyst for the Friedel-Crafts Alkylation of Indoles with β-Nitrostyrenes》 were Markad, Datta; Mandal, Sanjay K.. And the article was published in ACS Catalysis in 2019. Name: 2-Bromoacetamide The author mentioned the following in the article:

A primary-amide-functionalized metal organic framework, {[Zn2(2-BQBG)(BDC)2]·10H2O}n (in which 2-BQBG = 2,2′-(butane-1,4-diylbis((quinolin-2-ylmethyl)azanediyl))diacetamide and BDC = 1,4-benzenedicarboxylate), has been found to be a highly efficient hydrogen-bond-donating (HBD) heterogeneous catalyst for the Friedel-Crafts alkylation of indole with β-nitrostyrenes under mild reaction conditions (catalyst loading: 3 mol %; reaction conditions: 12 h and 35 °C). The catalyst can be easily separated from the reaction mixture by simple filtration for its reuse in four consecutive cycles with very little loss of activity. More importantly, the one-pot room temperature synthesis of {[Zn2(2-BQBG)(BDC)2]·10H2O}n from the self-assembly of Zn(OAc)2·2H2O and 2-BQBG (in CH3OH) and Na2BDC (in H2O) can be easily scaled-up for obtaining multigram quantities in few hours. In order to showcase its versatility, the substrate scope included a variety of substituted indoles and different β-nitrostyrene derivatives forming the desired products in good to high yields. For its catalytic action, a direct proof for the key step in the proposed mechanism, based on the interaction of a primary-amide group in the 2-BQBG ligand with the nitro group of β-nitrostyrene through hydrogen bonding, is provided from the enhancement in fluorescence intensity of {[Zn2(2-BQBG)(BDC)2]·10H2O}n upon successive addition of β-nitrostyrene. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Synthesis included an article by Murre, Aleksandra; Erkman, Kristin; Kaabel, Sandra; Jarving, Ivar; Kanger, Tonis. Computed Properties of C2H4BrNO. The article was titled 《Diastereoselective [2,3]-Sigmatropic Rearrangement of N-Allyl Ammonium Ylides》. The information in the text is summarized as follows:

A diastereoselective method was developed for the [2,3]-sigmatropic rearrangement of N-allyl ammonium ylides R1CH=CHCH2NR2R3CH2C(O)R4 [R1 = H, Me, Ph, 2-thienyl, etc.; R2 = Me; R3 = Me, Bn; R2R3 = (CH2)4; R4 = OMe, NHBoc, N-pyrrolidinyl, etc.], affording rearrangement products CH2=CHCHR1CH(C(O)R4)NR2R3 in up to 95% isolated yields and 97:3 dr, most of the desired products were formed within 1 min. For the asym. reaction, a chiral auxiliary was introduced to the starting compound, affording the rearrangement product with high diastereoselectivities. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8Computed Properties of C2H4BrNO)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Computed Properties of C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer’s disease》 was written by Sun, Yi; Huang, Jiaxuan; Chen, Yufei; Shang, Hao; Zhang, Wannian; Yu, Jianqiang; He, Ling; Xing, Chengguo; Zhuang, Chunlin. Related Products of 683-57-8 And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway works as the key regulator against oxidative stress damage in many cells and organs. It has been a widely proposed therapeutic target for neurodegenerative diseases, including Alzheimer’s disease (AD). This study aimed at determining the neuroprotective activity of 9 (NXPZ-2), a small-mol. compound that directly inhibits the Keap1-Nrf2 protein-protein interaction, in an amyloid beta 1-42 (Aβ1-42) oligomer intracerebroventricularly (i.c.v.) injected mouse model. Behavioral tests showed that NXPZ-2 treatment dose-relatedly ameliorated learning and memory dysfunction in Aβ1-42-treated mice. HE and Nissl staining showed that NXPZ-2 improved brain tissue pathol. changes in AD mice by increasing neuron quantity and function. Western blot anal. of the hippocampus and cortex showed up-regulated Nrf2 in whole cell lysate, with increased nuclear translocation to increase Nrf2-targeted antioxidant enzymes (HO-1, NQO-1) and decreased p-Tau in NXPZ-2-treated mice. ELISA results showed that NXPZ-2 treatment increased serum Nrf2 and significantly decreased serum Aβ1-42 levels in AD mice. Furthermore, hippocampal and cortical superoxide dismutase (SOD) and glutathione (GSH) levels increased, while malondialdehyde (MDA) levels decreased. No obvious toxicity was observed in primary cultured mouse cortical neurons and organs with NXPZ-2 treatment. No ameliorative effect was observed of NXPZ-2 in Nrf2 knockout AD mice. Collectively, our findings demonstrated that NXPZ-2 could be a promising therapeutic agent against AD, and provided the first set of exptl. evidence, in a mouse model, to support Keap1-Nrf2 interaction as a validated target for the Nrf2 reactivation in AD.2-Bromoacetamide(cas: 683-57-8Related Products of 683-57-8) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Related Products of 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics