Category: 67341-01-9

Synthetic Route of 67341-01-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67341-01-9, name is tert-Butyl (2-hydroxy-1-phenylethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1-(2,6-difluoro-benzyl)-5-nitro-1H-pyrimidine-2,4-dione (82 mg, 0.29 mmol), ((R)-2-hydroxy-1-phenyl-ethyl)-carbamic acid tert-butyl ester (69 mg, 0.29 mmol), and triphenylphosphine (114 mg, 0.44 mmol) were dissolved in anhydrous tetrahydrofuran (2 mL). To this solution was added diethyl azodicarboxylate (200mu?, 0.44 mmol), followed by stirring at room temperature for 4 hrs. The solution was concentrated, after which the residue was purified using silica gel chromatography (eluent: hexane/ethyl acetate/dichloromethane, 3/1/1) and dried in a vacuum to afford 67 mg of the compound as a colorless oil (yield 67%). 1H NMR (300MHz, CDCl3) delta 1.30(9H, s), 3.40(1H, d), 4.50(1H, m), 5.08-5.27(4H, m), 7.02(2H, t), 7.26-7.47(6H, m), 8.78 (1H, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sk Chemicals Co., Ltd.; EP2390250; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 67341-01-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67341-01-9, name is tert-Butyl (2-hydroxy-1-phenylethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1-(2,6-difluoro-benzyl)-5-nitro-1H-pyrimidine-2,4-dione (82 mg, 0.29 mmol), ((R)-2-hydroxy-1-phenyl-ethyl)-carbamic acid tert-butyl ester (69 mg, 0.29 mmol), and triphenylphosphine (114 mg, 0.44 mmol) were dissolved in anhydrous tetrahydrofuran (2 mL). To this solution was added diethyl azodicarboxylate (200mu?, 0.44 mmol), followed by stirring at room temperature for 4 hrs. The solution was concentrated, after which the residue was purified using silica gel chromatography (eluent: hexane/ethyl acetate/dichloromethane, 3/1/1) and dried in a vacuum to afford 67 mg of the compound as a colorless oil (yield 67%). 1H NMR (300MHz, CDCl3) delta 1.30(9H, s), 3.40(1H, d), 4.50(1H, m), 5.08-5.27(4H, m), 7.02(2H, t), 7.26-7.47(6H, m), 8.78 (1H, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sk Chemicals Co., Ltd.; EP2390250; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67341-01-9, name is tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, A new synthetic method of this compound is introduced below., Formula: C13H19NO3

General procedure: To a solution of compound 4 (1 mmol) in CH2Cl2 (3 mL) wereadded trimethylamine (1.3 mmol) and methansulfonylchloride(1.1 mmol). After stirring at room temperature for 30 min, themixture was diluted with dichloromethane and washed withsaturated sodium bicarbonate solution. The organic layer was driedover sodium sulfate and filtered. After concentration, the filtratewas dried in vacuo to give compound 4a. The mixture of compound9 or 10 (1 mmol), the mesylate 4a (2.5mmol) and K2CO3 (5mmol) inDMF (10 mL) was stirred at 70 C overnight. The reaction mixturewas cooled to ambient temperature, diluted with ethyl acetate, andwashed with saturated ammonium chloride solution. The organiclayer was concentrated, then the residue was purified using silicagel and amine silica gel chromatography (hexane/EtOAc, 2:1). Thealkylated compound (1 mmol) in CH2Cl2 (40 mL) was treated withTFA (2 mL), stirring at room temperature for 3 h. The reactionmixture was neutralized with saturated NaHCO3 and extractedwith CH2Cl2 twice. The organic layer was concentrated, then purifiedusing silica gel chromatography (CH2Cl2/MeOH, 15:1-20:1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kim, Seon-Mi; Lee, Minhee; Lee, So Young; Lee, Soo-Min; Kim, Eun Jeong; Kim, Jae Sun; Ann, Jihyae; Lee, Jiyoun; Lee, Jeewoo; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 413 – 424;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 67341-01-9, These common heterocyclic compound, 67341-01-9, name is tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-Boc-D-phenylglycinol (5.0 kg), triethylamine (3.55 L), and dimethylformamaide (10.54 L) were charged to a reactor, agitated, and the mixture was cooled to 0 0C. Methanesulfonyl chloride (1.79 L) was charged through a dip-tube while maintaining the temperature below 5 0C. After completion of the reaction, acetone (15.0 L) was charged to the reactor while maintaining temperature below 5 0C. Water (12.0 L) was charged to the mixture over 3 hr, maintaining temperature below 5 0C, during which time crystallization occurred. An additional portion of water (18 L) was added while maintaining the temperature below 5 0C. The mixture was filtered and the cake was washed with 2:1 (v/v) water: acetone three times (2 x 10 L, 1 x 6600 L) and dried between 25- 40 0C under vacuum to provide methanesulfonic acid (S)-3-tert- butoxycarbonyl-amino-3-phenyl-propyl ester Id (6.278 kg, 94.5% molar yield) as a white solid. LCMS (ESI) m/z 216.0 (M-100(Boc)H+)

Statistics shows that tert-Butyl (2-hydroxy-1-phenylethyl)carbamate is playing an increasingly important role. we look forward to future research findings about 67341-01-9.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2009/62087; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 67341-01-9, name is tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67341-01-9, Recommanded Product: 67341-01-9

Synthesis of S3, a compound of formula I: Weigh 1.0 g, 1.0 equiv. of the compound of formula X in the reactor, based on the compound of formula X,1.2equiv. of the compound of formula IV is added to the reactor, 1.5 equiv. of triphenylphosphine, at room temperature, and the DIAD of 2.5equiv. is added to the reactor. After stirring the reaction for 5.0 h at room temperature, the reaction solution was concentrated to dryness. Concentrated residue in ethyl acetate and distribute in 1.0N aqueous hydrochloric acid, separate the organic phase, after washing the organic phase with a saturated aqueous solution of sodium hydrogencarbonate and brine, the organic phase was dried over sodium sulfate and concentrated. The concentrate is separated by column chromatography to give a compound of formula I in a yield of 80%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anhui Huasheng Pharmaceutical Technology Co., Ltd.; Hu Zhigang; Xu Liangzhi; He Darong; Du Xiaopeng; Qian Zhujin; He Yong; Chen Yuelei; (14 pag.)CN109761913; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics