Electric Literature of 67046-22-4, The chemical industry reduces the impact on the environment during synthesis 67046-22-4, name is 6,7-Dihydro-5H-pyrido[2,3-b]azepin-8(9H)-one, I believe this compound will play a more active role in future production and life.
At -78C, 4.5 mL of 2.0 M lithium diisopropylamide-tetrahydrofuran solution and 300 mg of paraformaldehyde were added to tetrahydrofuran (30 mL) solution of 367 mg of the compound of the above 1, and gradually heated up to room temperature. At room temperature, this was stirred overnight, and then water was added to the reaction liquid and extracted with ethyl acetate. The ethyl acetate layer was dried with anhydrous sodium sulfate, the solvent was evaporated off under reduced pressure, and the residue was separated and purified through partitioning thin-layer chromatography (chloroform/methanol = 10/1) to obtain 111 mg of the entitled compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6,7-Dihydro-5H-pyrido[2,3-b]azepin-8(9H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1726590; (2006); A1;,
Amide – Wikipedia,
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