Category: 65645-88-7

Dobashi, Yasuo; Dobashi, Akira; Hara, Shoji published an article in 1984, the title of the article was Chiral recognition conducted by tartaric acid derivatives in nonaqueous media.SDS of cas: 65645-88-7 And the article contains the following content:

Chiral recognition of hydroxycarboxylic acids, amino acids and 1,2-diols using diastereomeric complexation based on H bonding with L-(+)-N,N’-diisopropyltartramide is described (liquid-solid chromatog.). The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).SDS of cas: 65645-88-7

The Article related to chiral recognition tartramide, tartaric acid chiral recognition, chromatog tartaric chirality, hydrogen bond tartramide, hydroxycarboxylase enantiomerism chromatog, amino acid enantiomerism, diol enantiomerism and other aspects.SDS of cas: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 25, 2009, Liu, Julie published a patent.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of tetrahydroisoquinoline derivatives as orexin receptor antagonists. And the patent contained the following:

This title compounds with general formula I [wherein each Z is independently selected from hydrogen or deuterium; each R is independently selected from CD3, CD2H, CDH2, or CH3, and when each R is CH3 then at least one Z is deuterium] or pharmaceutically acceptable salts thereof were prepared as dual OX-1/OX-2 orexin receptor antagonists for the treatment of obesity, bulimia, anorexia nervosa, insomnia, narcolepsy, sleep apnea, jet-lag syndrome, or memory impairment. For example, compound II·HCl was prepared in a multi-step synthesis, with the last step being the condensation of (1S)-[1,2,3,4-tetrahydro-3,3,4,4-d4]-[6,7-dimethoxy-d6]-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-isoquinoline hydrochloride (preparation given) and toluene-4-sulfonic acid [(S)-1-[(methyl-d3)carbamoyl]-1-phenylmethyl] ester (preparation given). The metabolic stability of compounds I has been tested using pooled liver microsomal incubation. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to preparation tetrahydroisoquinoline orexin receptor antagonist treatment eating disorder sleep, treatment obesity bulimia anorexia nervosa insomnia narcolepsy sleep apnea, human jet lag syndrome memory impairment treatment and other aspects.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 14, 1996, Roucoux, Alain; Thieffry, Laurent; Carpentier, Jean-Francois; Devocelle, Marc; Meliet, Catherine; Agbossou, Francine; Mortreux, Andre; Welch, Alan J. published an article.Recommanded Product: 65645-88-7 The title of the article was Amidophosphine-Phosphinites: Synthesis and Use in Rhodium-Based Asymmetric Hydrogenation of Activated Keto Compounds. Crystal Structure of Bis[(μ-chloro)((S)-2-((diphenylphosphino)oxy)-2-phenyl- N-(diphenylphosphino)-N-methylacetamide)rhodium(I)]. And the article contained the following:

Amidophosphine-phosphinite ligands (AMPP) derived from (S)-N-benzylmandelamide ((S)-R,R’-benzylmandelNOP (S)-1 (R = R’ = phenyl) and (S)-7 (R = Ph, R’ = cyclopentyl)), (S)-N-methylmandelamide ((S)-R,R’-methylmandelNOP (S)-2 (R = R’ = phenyl) and (S)-8 (R = Ph, R’ = cyclopentyl)), (S)-N-methyllactamide ((S)-R,R’-methyllactaNOP (S)-3 (R = R’ = phenyl) and (S)-9 (R = Ph, R’ = cyclopentyl)), and (S)-2-(hydroxymethyl)-2-pyrrolidinone ((S)-R,R’-oxoProNOP (S)-4-6 and (S)-10 (R, R’ = Ph, cyclohexyl, cyclopentyl)) have been prepared in high yields (60-94%) and reacted with rhodium precursors to prepare neutral “Rh{AMPP}” complexes of general formula [Rh{AMPP}X]2, where X = Cl, I, OCOCH3, OCOCF3, and OCOC3F7. The crystal structure of [Rh{(S)-Ph,Ph-methylmandelNOP}Cl]2 (12) has been determined The rhodium atom has a cis square-planar coordination, and the seven-membered chelate ring has a boat conformation with the nitrogen atom in the mean plane RhP2. Complexes have been used as catalyst precursors for the asym. hydrogenation of dihydro-4,4-dimethyl-2,3-furandione (27) and N-benzylbenzoylformamide (29) giving the corresponding optically active hydroxy compounds in high yields and low to high enantiomeric excesses (28-98.7% ee and 13-87% ee, resp.). Catalytic activities (turnover frequency at 50% conversion at room temperature up to 3300 h-1) as well as the enantioselectivities depended strongly on the nature of the substituents on phosphorus as well as on the nature of the non chiral ligands. Catalyst precursor [Rh{(S)-Cp,Cp-oxoProNOP}OCOCF3]2 afforded (R)-pantolactone in 98.7% ee. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: 65645-88-7

The Article related to amidophosphine phosphinite preparation reaction rhodium complex, asym hydrogenation catalyst rhodium amidophosphine phosphinite, mandelamide lactamide phosphino preparation reaction rhodium, crystal mol structure amidophosphine phosphinite rhodium and other aspects.Recommanded Product: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics