Category: 65645-88-7

On July 9, 2009, Bappert, Erhard; De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Nazir, Zarghun; Skranc, Wolfgang; Spindler, Felix; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Computed Properties of 65645-88-7 The title of the patent was Process for the preparation of an enantiomeric trisubstituted 3,4-dihydroisoquinoline derivative. And the patent contained the following:

The invention relates to a process for the preparation of the compound of formula I by enantioselective hydrogenation of the corresponding imine intermediate catalyzed by bis[chloro-1,5-cyclooctadiene-iridium] and (S)-1-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]ferrocene. Reaction conditions, such as additives, ratios of substrate/catalyst and solvent systems, play roles respect to enantioselectivity and yields therefore were examined Other metal/chiral ligand catalyst systems were evaluated for the enantioselective hydrogenation of the substrate. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Computed Properties of 65645-88-7

The Article related to dihydroisoquinoline derivative hydrogenation iridium chiral ligand, tetrahydroisoquinoline derivative asym preparation, iridium chiral ligand asym hydrogenation catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Computed Properties of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Feng-Hua; Wang, Chen; Xie, Jian-Hua; Zhou, Qi-Lin published an article in 2019, the title of the article was Synthesis of Tridentate Chiral Spiro Aminophosphine-Oxazoline Ligands and Application to Asymmetric Hydrogenation of α-Keto Amides.Category: amides-buliding-blocks And the article contains the following content:

A new type of tridentate chiral spiro aminophosphine-oxazoline ligands (SpiroOAP) were synthesized through four steps. The SpiroOAP ligands are highly efficient for the asym. hydrogenation of α-keto amides, providing a variety of synthetically useful α-hydroxy amides with excellent enantioselectivity (up to 98% ee) and turnover numbers (up to 10,000). The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Category: amides-buliding-blocks

The Article related to chiral spiro aminophosphine oxazoline ligand preparation, keto amide aminophosphine oxazoline iridium catalyst enantioselective hydrogenation, hydroxy amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 5, 2021, Li, Yanxiong; Meng, Faming; Xu, Liang; Guo, Jun published a patent.Formula: C9H11NO2 The title of the patent was Preparation method of aprepitant intermediate (2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine. And the patent contained the following:

The title preparation method includes mixing compound I ((R)-6-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine), chiral catalyst, acid (protonic acid such as trifluoroacetic acid, acetic acid, etc.) and solvent (chloroform, dichloromethane, etc.) for reaction to obtain the final aprepitant intermediate (2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine (compound II). The chiral catalyst is compound including bis((S)-2-amino-2-oxo-1-phenylethyl) 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, bis((S)-2-(methylamino)-2-oxo-1-phenylethyl) 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, etc. The invention has high yield and product purity, and is environment-friendly. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Formula: C9H11NO2

The Article related to aprepitant intermediate preparation, morpholine fluorophenyl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Formula: C9H11NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kisbye, J.; Byskov Madsen, N. published an article in 1977, the title of the article was Studies on sympathomimetic amines. X. Racemization of halostachine and phenylephrine.SDS of cas: 65645-88-7 And the article contains the following content:

The rates of racemization of (+)-halostachine (I) and (-)-phenylephrine (II) at 90-130° in strong acid solution are approx. equal and much lower than that for (-)-oxedrine. A linear dependence between the 1st-order rate constant and pH was observed and the activation energies and frequency factors for racemization of I and II were the same. An SN1 mechanism with carbonium ion formation as the rate-determining step was indicated. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).SDS of cas: 65645-88-7

The Article related to racemization halostachine phenylephrine kinetics, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.SDS of cas: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2008, Aissaoui, Hamed; Boss, Christoph; Gude, Markus; Koberstein, Ralf; Sifferlen, Thierry published a patent.HPLC of Formula: 65645-88-7 The title of the patent was Preparation of 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives as orexin receptor antagonists. And the patent contained the following:

Title compounds represented by the formula I [wherein X = CH2 or O; R1 = independently phenyl; R2 = alkyl, alkenyl, halo, etc.; R3 = alkyl, alkoxymethyl or halo; R4 = alkyl; and pharmaceutically acceptable salts thereof] were prepared as orexin (OX) receptor antagonists. For example, II was provided in a multi-step synthesis starting from Knoevenagel condensation of 3,4-dimethylbenzaldehyde with malonic acid. I showed antagonistic activity on OX1 and OX2 receptors in intracellular calcium measurements. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).HPLC of Formula: 65645-88-7

The Article related to tetrahydroimidazopyrazine preparation orexin receptor antagonists, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.HPLC of Formula: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 30, 2009, Aissaoui, Hamed; Boss, Christoph; Koberstein, Ralf; Siegrist, Romain; Sifferlen, Thierry published a patent.Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was 5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine compounds as orexin receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention relates to 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives of formula I and to the use of such compounds as medicaments, especially as orexin (OX) receptor antagonists. Compounds of formula I wherein R4 is C1-4 alkyl; when R3 is cyclopropyl, then R2 is halo, CF3, C1-4 alkyl and vinyl, R1 is substituted phenyl; when R3 is C3-6 cycloalkyl-C1-4 alkyl, then R2 is halo, R1 is substituted phenyl; when R3 is -SO2-C1-4 alkyl, then R2 is halo, R1 is substituted phenyl; when R3 is -S-C1-4 alkyl, then R2 is halo, CF3 and vinyl, R1 is substituted phenyl; when R3 is C1-4 alkyl, then R2 is -SO0-2-C1-4 alkyl, R1 is substituted phenyl; when R3 is C1-4 alkoxy, then R2 is CF3, R1 is substituted phenyl; when R3 is CF3, then R2 is C1-4 alkyl, R1 is substituted phenyl; when R3 is C1-4 alkyl, then R2 is halo, R1 is substituted phenyl; and their pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared via N-alkylation of 1-chloro-8-[2-(4-chloro-3-fluorophenyl)ethyl]-3-cyclopropyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine with toluene-4-sulfonic acid (S)-methylcarbamoylphenyl Me ester. All the invention compounds were evaluated for their OX receptor antagonistic activity. From the assay, it was determined that II exhibited the IC50 values of 43 nM and 11 nM against OX1 and OX2, resp. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to tetrahydro imidazopyrazine compound preparation orexin receptor antagonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Polonski, T. published an article in 1983, the title of the article was Optical activity of lactones and lactams – II. Chiroptical properties of 4-oxazolidinones.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide And the article contains the following content:

Several optically active 4-oxazolidinones (e.g., I) were obtained from amides or N-methylamides of α-hydroxy acids. Solvent and substituent effects on their CD were studied. The predominance of the envelope conformation was established for these compounds, the degree of puckering being enhanced by polar solvents. The folded form with the aromatic ring facing the oxazolidinone ring was observed for 5-benzyloxazolidinone derivatives The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to cd oxazolidinone conformation, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 22, 2021, Li, Yanxiong; Xu, Liang; Meng, Faming; Yu, Yonghai published a patent.Recommanded Product: 65645-88-7 The title of the patent was Preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine and chiral catalyst thereof. And the patent contained the following:

The invention relates to preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine and chiral catalyst thereof, which has the advantages of high yield and simple method, low cost, environmentally friendly and safety. The (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine was prepared by the following steps: mixing 1-(3-ethoxy-4-methoxy Phenyl)-2-(methylsulfonyl)vinylamine, chiral catalyst I, acid and solvent, performing isomerization to obtain the final product; where R=hydrogen atom, C1-20 linear alkyl, C3-20 branched chain alkyl, C3-10 cycloalkyl, C3-10 heterocyclyl, C1-20 alkoxy, trifluoromethyl, halogen, amino, cyano, hydroxyl, nitro, ester, amide, substituted or unsubstituted C6-20 aryl, substituted or unsubstituted C5-20 heteroaryl. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: 65645-88-7

The Article related to preparation ethoxymethoxyphenylmethylsulfonylethylamine chiral catalyst isomerization, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Recommanded Product: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 14, 2010, De Vries, Maria Andreas Hendrikus; Domin, Doris; Helms, Matthias; Imboden, Chistoph; Koberstein, Ralph; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Maria Gerardus Karel; Stichler, Juergen published a patent.Formula: C9H11NO2 The title of the patent was Process and intermediates for preparation of almorexant hydrochloride.. And the patent contained the following:

(S)-6,7-Dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydroisoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), taniaphos, and I2 in a solvent at 1-200 bar H2. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Formula: C9H11NO2

The Article related to almorexant hydrochloride preparation, methoxytrifluoromethylphenylethyldihydroisoquinoline acetate chiral preparation, hydroisoquinoline asym hydrogenation taniaphos cyclopentadiene iridium chloride and other aspects.Formula: C9H11NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 9, 2009, De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Koberstein, Ralf; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Synthetic Route of 65645-88-7 The title of the patent was Process for preparation of (S)-6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-1,2,3,4-tetrahydro-1H-isoquinoline acetate via asymmetric hydrogenation. And the patent contained the following:

(S)-6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-1,2,3,4-tetrahydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), (S)-1-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]ferrocene, iodine, and a solvent under 1-200 bar H2. The above reaction was carried out at 5 bar H2 and 30° in CH2Cl2 with a I2/Ir ratio of 2:1 to give the title product in 95% enantiomeric excess with 100% conversion. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Synthetic Route of 65645-88-7

The Article related to phenethyldihydroisoquinoline asym hydrogenation iridium phosphinoferrocene catalyst, methoxytrifluoromethylphenylethyltetrahydroisoquinoline acetate chiral preparation, almorexant hydrochloride preparation and other aspects.Synthetic Route of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics