Category: 65645-88-7

On November 3, 2017, Gu, Guoxian; Yang, Tilong; Yu, Ouran; Qian, Hua; Wang, Jiang; Wen, Jialin; Dang, Li; Zhang, Xumu published an article.Application of 65645-88-7 The title of the article was Enantioselective Iridium-Catalyzed Hydrogenation of 伪-Keto Amides to 伪-Hydroxy Amides. And the article contained the following:

A highly enantioselective iridium-catalyzed hydrogenation of 伪-keto amides to form 伪-hydroxy amides has been achieved with excellent results (up to >99% conversion and up to >99% ee, TON up to 100 000). As an example, this protocol was applied to the synthesis of (S)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol, the enantiomer of norepinephrine, which is widely used as an injectable drug for the treatment of critically low blood pressure. D. functional theory (DFT) calculations were also carried out to reveal the reaction mechanism. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Application of 65645-88-7

The Article related to enantioselective iridium catalyzed hydrogenation keto amide hydroxy amide, General Organic Chemistry: Synthetic Methods and other aspects.Application of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 25, 2020, Li, Yanxiong; Meng, Faming; Xu, Liang; Guo, Jun published a patent.Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Environmentally-friendly preparation method of Avibactam intermediate. And the patent contained the following:

A process for preparation of Avibactam intermediate is disclosed. The process comprises mixing compound I, chiral catalyst, protic acid and solvent, stirring, filtering, and concentrating to obtain (2S,5R)-5-[(phenylmethoxy)amino]-2-piperidinecarboxamide, wherein the chiral catalyst is represented by the structure II (R = H, C1-20 alkyl, C3-10 cycloalkyl, (un)substituted phenyl). The process is simple and cost-effective, has high yield and purity, and suitability for large-scale industrial production The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to avibactam intermediate preparation stereoselective catalytic hydrogenation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Xu, Liang; Liu, Yan; Meng, Faming; Lu, Hanbin; Li, Youzhi published a patent.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application. And the patent contained the following:

The invention discloses a preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application, which has the advantages of simple synthesis method, mild reaction conditions, and can effectively reduce the production cost and improve the production safety. The hydrogenation reagent is shown in formula I, wherein R is selected from hydrogen atom, linear alkyl with 1-20 carbon atoms, branched alkyl with 3-10 carbon atoms and branched alkyl with 3-10 carbon atoms-cycloalkyl group with 10 carbon atoms, or substituted or unsubstituted Ph group. The hydrogenation reagent was prepared via ring opening reaction and heterocyclization. The step of asym. hydrogenation includes the following steps: mixing the substrate, the hydrogenation reagent, proton acid and organic solvent, separating and purifying after the reaction is complete. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to preparation diamide dihydropyridine hydrogenation reagent ring opening reaction heterocyclization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 25, 2020, Li, Yanxiong; Meng, Faming; Xu, Liang; Guo, Jun published a patent.Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Environmentally-friendly preparation method of Avibactam intermediate. And the patent contained the following:

A process for preparation of Avibactam intermediate is disclosed. The process comprises mixing compound I, chiral catalyst, protic acid and solvent, stirring, filtering, and concentrating to obtain (2S,5R)-5-[(phenylmethoxy)amino]-2-piperidinecarboxamide, wherein the chiral catalyst is represented by the structure II (R = H, C1-20 alkyl, C3-10 cycloalkyl, (un)substituted phenyl). The process is simple and cost-effective, has high yield and purity, and suitability for large-scale industrial production The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to avibactam intermediate preparation stereoselective catalytic hydrogenation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Xu, Liang; Liu, Yan; Meng, Faming; Lu, Hanbin; Li, Youzhi published a patent.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application. And the patent contained the following:

The invention discloses a preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application, which has the advantages of simple synthesis method, mild reaction conditions, and can effectively reduce the production cost and improve the production safety. The hydrogenation reagent is shown in formula I, wherein R is selected from hydrogen atom, linear alkyl with 1-20 carbon atoms, branched alkyl with 3-10 carbon atoms and branched alkyl with 3-10 carbon atoms-cycloalkyl group with 10 carbon atoms, or substituted or unsubstituted Ph group. The hydrogenation reagent was prepared via ring opening reaction and heterocyclization. The step of asym. hydrogenation includes the following steps: mixing the substrate, the hydrogenation reagent, proton acid and organic solvent, separating and purifying after the reaction is complete. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to preparation diamide dihydropyridine hydrogenation reagent ring opening reaction heterocyclization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 25, 2019, Zhou, Qilin; Zhang, Fenghua; Xie, Jianhua; Wang, Lixin published a patent.Related Products of 65645-88-7 The title of the patent was Chiral spiro phosphine-amino-oxazoline tridentate ligand, its preparation method and application. And the patent contained the following:

A chiral spiro phosphine-amino-oxazoline tridentate ligand having ruthenium complex exhibits high catalytic activity (TON to 10,000) and enantioselectivity (up to 98% ee) in the asym. hydrogenation of α-ketoamide, which has practical value is provided. The chiral spiro phosphine-amino-oxazoline tridentate ligand comprises a compound of formula I or an enantiomer, racemate, or a catalytically acceptable salt thereof, and having a main structural feature of having a chiral spiroindoline skeleton and having a chiral oxazoline group. The method for preparing a chiral spiro phosphine-amino-oxazoline tridentate ligand by racemic or optically active 7-diaryl/alkylphosphino-7/-aminospiroindole represented by formula 1 having a chiral spiroindoline skeleton used as a starting material. The chiral spiro phosphine-amino-oxazoline tridentate ligand forms a complex with the transition metal salt and can be used to catalyze the asym. catalytic hydrogenation of the carbonyl compound The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Related Products of 65645-88-7

The Article related to chiral spiro phosphine amino oxazoline preparation enantioselective hydrogenation catalyst, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Related Products of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 15, 2005, Weller, Thomas; Koberstein, Ralf; Aissaoui, Hamed; Clozel, Martine; Fischli, Walter published a patent.Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of substituted 1,2,3,4-tetrahydroisoquinolines as orexin receptor antagonists. And the patent contained the following:

Title compounds I [R1-2 = H, alkoxy; R3 = alkyl; X = CH, N] are prepared For instance, II is prepared from a Ru-catalyzed enantioselective alkylation of 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline with 1-bromomethyl-4-trifluoromethylbenzene followed by alkylation of the resulting isoquinoline with (S)-α-(4-toluenesulfonyloxy)-N-methylphenylacetamide (preparation given). Compounds of the invention are orexin antagonists with activity in the nanomolar range. I are useful for the treatment of, e.g., anxiety and depression. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to tetrahydroisoquinoline orexin receptor antagonist process preparation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 29, 2020, Li, Yanxiong; Xu, Liang; Meng, Faming; Yu, Yonghai published a patent.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Method for synthesizing (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline using 1-phenyl-3,4-dihydroisoquinoline. And the patent contained the following:

The present invention relates to a (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline synthesizing method comprising: mixing 1-phenyl-3,4-dihydroisoquinoline, chiral catalyst, acid and solvent, and reacting them. The (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline with high chiral purity can be generated during the hydrogenation reduction process. The product is easy to sep. and purify, and the yield is high. In addition, the reaction conditions are mild, the process is stable, the reaction operation is simple, convenient and safe, the production cost is low, the three-waste treatment is simple and feasible, the environment is friendly, the equipment used in the reaction process is simple, the raw materials are easy to obtain, and the method is suitable for industrial production The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to phenyltetrahydroisoquinoline preparation stereoselective hydrogenation phenyldihydroisoquinoline, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan published an article in 1989, the title of the article was Enantiospecific synthesis of (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline from (+)-(S)-2-methylamino-1-phenylethanol.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide And the article contains the following content:

Acid-promoted cyclization of (+)-(R)-N-(3,4-dimethoxybenzyl)halostachine tricarbonylchomium at -20° is highly stereoselective proceeding with retention of configuration to yield, after removal of the tricarbonylchromium unit, homochiral (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline. In contrast, cyclization of (-)-(R)-N-(3,4-dimethoxybenzyl)halostachine under acidic conditions at -20° showed poor stereoselectivity giving predominantly the tetrahydroisoquinoine product corresponding to inversion of configuration, (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, with an enantiomeric excess of 54%. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to methylaminophenylethanol conversion isoquinoline derivative, isoquinoline derivative stereoselective synthesis, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 20, 2012, Bappert, Erhard; De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Nazir, Zarghun; Skranc, Wolfgang; Spindler, Felix; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Related Products of 65645-88-7 The title of the patent was Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative. And the patent contained the following:

The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Related Products of 65645-88-7

The Article related to dihydroisoquinoline derivative hydrogenation iridium chiral ligand, tetrahydroisoquinoline derivative asym preparation, iridium chiral ligand asym hydrogenation catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Related Products of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics