Synthetic Route of 6529-94-8, A common heterocyclic compound, 6529-94-8, name is 7-Methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one, molecular formula is C9H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 7-mthoxy-4H-benzo[1,4]oxazin-3-one (1.9 g, 10.6 mmol) in AcOH (20 ml_), is added droppedwise fuming HN03 (13.7 ml_) below 10 C. After stirred for 3 h, the reaction mixture is poured into ice cold water and the resulting white solids are collected by filtration. The solids are washed with H20 and hexane and dried in vacuo to give 7-mthoxy-6-nitro-4H-benzo[1,4]oxazin-3-one (1.4 g, 59%)
The synthetic route of 6529-94-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2006/21454; (2006); A2;,
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