Category: 64559-06-4

Yang, Jianzhong published the artcile3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents, Product Details of C8H9NOS, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(5), 1424-1427, database is CAplus and MEDLINE.

Small mols. with oxathiazol-2-one moiety were recently reported as potent inhibitors of Mycobacterium bovis var. bacilli Calmette-Guerin (BCG), among which HT1171 (I) was the most potent and selective proteasome inhibitor. Herein we synthesized a series of novel compounds by bioisosteric replacement of the oxathiazol-2-one ring with 3H-1,2,4-dithiazol-3-one, and also fifteen 1,3,4-oxathiazol-2-one mols. in order for potency comparison and structure-activity relationship elucidation since their antibacterial effects on the virulent strains were not evaluated before. All the compounds were assessed for antitubercular activities on the virulent H37Rv strain by a serial dilution method. Among the tested compounds, 3H-1,2,4-dithiazol-3-one derivative II was found to be the most active with a lowest MIC₉₀ value of 1 μg/mL. Furthermore, the cytotoxicities of all the compounds against normal human liver cell line L02 were determined by an MTT method. Compound II displayed a lower inhibitory ratio than HT1171 at the concentration of 100 μM, indicating its better safety profile.

Bioorganic & Medicinal Chemistry Letters published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C27H39ClN2, Product Details of C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pandey, Lokesh Kumar published the artcileA thiophosphoryl chloride assisted transformation of arylaldoximes to thioamides, COA of Formula: C8H9NOS, the publication is Synthesis (2012), 44(3), 377-379, database is CAplus.

Primary benzothioamides were accessed from benzaldoximes (benzaldehyde oximes) via benzonitriles in a sequential tandem approach utilizing thiophosphoryl chloride as a dehydrating and thionating agent.

Synthesis published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, COA of Formula: C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Cashman, John R. published the artcileRelative hepatotoxicity of ortho and meta monosubstituted thiobenzamides in the rat, Application In Synthesis of 64559-06-4, the publication is Chemico-Biological Interactions (1983), 45(3), 341-7, database is CAplus and MEDLINE.

The hepatotoxicity of ortho and meta monosubstituted thiobenzamides was studied in rats injected i.p. with 2.0 mmol/kg of various monosubstituted compounds Among the meta-substituted compounds, hepatotoxicity varied in strict accordance with the electronic character of the substituent, whereas the ortho-substituted compounds showed no toxicity at comparable doses regardless of the nature of the substituent. Explanations for these substituent effects are provided in terms of the chem. reactivity of the compounds and their corresponding S-oxide and S,S-dioxide metabolites.

Chemico-Biological Interactions published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Application In Synthesis of 64559-06-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nagl, Michael published the artcileThe BF₃.OEt₂-assisted conversion of nitriles into thioamides with Lawesson’s reagent, SDS of cas: 64559-06-4, the publication is Synthesis (2008), 4012-4018, database is CAplus.

A method for the thiolysis of nitriles by applying Lawesson’s reagent and facilitated by the addition of BF₃.OEt₂ is reported. The method opens an easy access to primary thioamides. Aromatic, benzylic, and aliphatic nitriles were converted into the corresponding thioamides in high to quant. yields (even in unfavorable cases, e.g., ortho-substituted benzonitriles). The reaction was performed in MeO(CH₂)₂OMe/THF or PhMe/OEt₂ solvent mixtures at 20-50°, and exhibited considerable selectivity in the case of multifunctional nitrile substrates, such as cyanomethyl N-acetylphenylalaninate, BzCH₂CN, 4-NCC₆H₄CONH₂, 4-AcC₆H₄CN, or 3-pentenenitrile.

Synthesis published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, SDS of cas: 64559-06-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rihova, Martina published the artcilePhysical and physico-chemical properties of thiobenzamides. Part 11. High-performance liquid chromatography of thiobenzamide derivatives with ultraviolet photometric and electrochemical detection, Product Details of C8H9NOS, the publication is Journal of Chromatography (1986), 347-54, database is CAplus.

Twenty-five thiobenzamide derivatives were separated on a reversed-phase system on various stationary phases, with UV photometric and voltammetric detection. The best results were obtained by using a Partisil ODS column (10 μm, 250 mm × 4.6 mm inner diameter) with a mobile phase consisting of 0.05M NaH₂PO₄ with 30% (volume/volume) MeOH, containing 1.2 × 10^-4M EDTA, at a flow-rate of 1.0 mL/min. Voltammetric detection on a carbon-fiber electrode at +1.4 V (Ag-AgCl) is more sensitive than UV photometric detection at 254 nm, typical detection limits being ∼0.1 and 1.0 ng. Voltammetric calibration curves exhibit good linearity and the measurements are reproducible (relative standard deviation of ca. 2%).

Journal of Chromatography published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Product Details of C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Waisser, Karel published the artcileRemarks on the calculation of partition coefficients of thiobenzamides using the microsoft chembioofice program, Safety of 3-Methoxybenzothioamide, the publication is Folia Pharmaceutica Universitatis Carolinae (2013), 7-9, database is CAplus.

The study examined the lipophilicity of thiobenzamides investigated as potential antituberculotics. Logarithms of partition coefficients were calculated using the ChemBioOffice 2008 program (Microsoft) and the values verified by partition TLC. The derivatives with substituents in position 2 correlated worse than other substituted derivatives The paper shows that the program Microsoft ChemBioOffice which is used at the Faculty of Pharmacy is problematic.

Folia Pharmaceutica Universitatis Carolinae published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C15H14Cl2S2, Safety of 3-Methoxybenzothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Noei, Jalil published the artcileTiCl₃OTf-[bmim]Br, a novel and efficient catalyst system for chemoselective one-pot synthesis of thioamides from arylaldoximes, Product Details of C8H9NOS, the publication is Tetrahedron Letters (2008), 49(49), 6969-6971, database is CAplus.

The combination of TiCl₃OTf with 1-butyl-3-methylimidazolium bromide is an efficient and novel catalytic system for chemoselective one-pot transformation of arylaldoximes to their corresponding thioamides in high to excellent yields.

Tetrahedron Letters published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Product Details of C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Scott, Fraser J. published the artcileAn evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics, Quality Control of 64559-06-4, the publication is European Journal of Medicinal Chemistry (2016), 116-125, database is CAplus and MEDLINE.

A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimization towards novel treatments for Human and Animal African Trypanosomiases. Moreover, SAR indicates that the head group linking moiety is a significant modulator of biol. activity.

European Journal of Medicinal Chemistry published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C14H21BO2, Quality Control of 64559-06-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Morita, Mikio published the artcileFacile synthesis of 2-azaazulenes from thiobenzoyl isocyanates using trimethylsilyldiazomethane, Related Products of amides-buliding-blocks, the publication is Tetrahedron (2008), 64(8), 1753-1758, database is CAplus.

The reaction of trimethylsilyldiazomethane with thiobenzoyl isocyanates, in situ generated from thiazole-4,5-diones, yielded diazo ketones, which were converted into 2-azaazulenes by the intramol. Buchner reaction.

Tetrahedron published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Changliu published the artcileYnamide-Mediated Thioamide and Primary Thioamide Syntheses, Safety of 3-Methoxybenzothioamide, the publication is Journal of Organic Chemistry (2022), 87(9), 5617-5629, database is CAplus and MEDLINE.

Environmentally friendly ynamide-mediated thioamidation of monothiocarboxylic acids with amines or ammonium hydroxide for the synthesis of thioamides was described. Simple and mild reaction conditions tolerate a wide variety of functional groups such as hydroxyl, ester, tertiary amine, ketone, and amide moieties. Readily available NaSH served as the sulfur source, avoiding the use of toxic, expensive, and malodorous organic sulfur reagents and making this strategy environmentally friendly and practical. Importantly, the stereochem. integrity of α-chiral monothiocarboxylic acids was maintained during the activation step and subsequent aminolysis process, which offers a racemization-free strategy for peptide and protein C-terminal modification. Furthermore, a number of thioamide-modified drugs were prepared in good yields by this protocol and the synthesized primary thioamides were transformed into backbone thiazolyl modification peptides.

Journal of Organic Chemistry published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C15H20O6, Safety of 3-Methoxybenzothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics