Category: 64479-78-3

Safety of N-(Pyridin-4-yl)isonicotinamideOn March 5, 2015, O’Donovan, Megan E.; LaDuca, Robert L. published an article in Journal of Molecular Structure. The article was 《Zinc coordination polymers containing substituted isophthalate ligands and fragments from in situ hydrolysis of 4-pyridylisonicotinamide》. The article mentions the following:

Hydrothermal treatment of Zn nitrate, a 5-substituted isophthalic acid, and 4-pyridylisonicotinamide (4-pina) resulted in crystalline coordination polymers that incorporated different fragments formed by in situ hydrolysis of the 4-pina precursor. These materials were characterized by single crystal x-ray diffraction. In the case of {[4-ampyrH]2[Zn(hip)2]·H2O}n (1, 4-ampyrH = 4-aminopyridinium, hip = 5-hydroxyisophthalate), anionic [Zn(hip)2]n2n- (4,4) grid layers co-crystallize with protonated 4-ampyr cations. Using 5-nitroisophthalic acid (H2nip), [Zn7(isonic)4(OH)6(nip)2]n (2, isonic = isonicotinate) was formed. This material manifests [Zn7(OH)6]n cationic inorganic chain motifs linked by isonic and nip ligands into a noninterpenetrated 3-dimensional coordination polymer network with pcu topol. Luminescent behavior is attributed to intra-ligand MO transitions. The results came from multiple reactions, including the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Safety of N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Safety of N-(Pyridin-4-yl)isonicotinamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis and characterization of divalent metal complexes with bipyridylamide ligands》 were McMoran, Ethan P.; Mugenzi, Clement; Fournier, Kyle; Draganjac, Mark; Tony, Donavon; Jeong, Kwangkook; Powell, Douglas R.; Yang, Lei. And the article was published in Journal of Coordination Chemistry in 2016. Quality Control of N-(Pyridin-4-yl)isonicotinamide The author mentioned the following in the article:

Reaction of N-(4-pyridyl)picolinamide (4-ppa), N-(4-pyridyl)nicotinamide (4-pna), N-(4-pyridyl)isonicotinamide (4-pina), and N-(2-pyridyl)isonicotinamide (2-pina) with divalent metal salts gave six new coordination complexes. The x-ray structure of [Zn(4-ppa)2Cl2] (1) shows a mononuclear structure with interesting intermol. hydrogen bonding interactions. [Zn(4-pna)(OAc)2]n (2), [Cu(4-pna)(OTf)2(DMF)2]n.DMF (3), {[Zn(4-pina)(DMF)4](OTf)2}n (4), {[Fe(4-pina)(DMF)4](OTf)2}n (5), and [Cu(2-pina)(OTf)2(DMF)2]n.2DMF (6) are one-dimensional coordination polymers with conformational differences caused by the coordination donor disposition, which demonstrates the flexibility of the pyridylamide ligands in polymeric structures. Reflectance UV-visible spectra and thermal properties of the coordination polymers are also reported.N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Quality Control of N-(Pyridin-4-yl)isonicotinamide) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Quality Control of N-(Pyridin-4-yl)isonicotinamide The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Valverde-Munoz, Francisco Javier; Bartual-Murgui, Carlos; Pineiro-Lopez, Lucia; Munoz, M. Carmen; Real, Jose Antonio published their research in Inorganic Chemistry on August 5 ,2019. The article was titled 《Influence of Host-Guest and Host-Host Interactions on the Spin-Crossover 3D Hofmann-type Clathrates {FeII(pina)[MI(CN)2]2}·xMeOH (MI = Ag, Au)》.Name: N-(Pyridin-4-yl)isonicotinamide The article contains the following contents:

The synthesis, structural characterization and magnetic properties of two new isostructural porous 3-dimensional compounds {FeII(pina)[MI(CN)2]2}·xMeOH (x = 0-5; pina = N-(pyridin-4-yl)isonicotinamide; MI = AgI and x ∼ 5 (1·xMeOH); MI = AuI and x ∼ 5 (2·xMeOH)) are presented. The single-crystal x-ray diffraction analyses revealed that the structure of 1·xMeOH (or 2·xMeOH) presents two equivalent doubly interpenetrated 3-dimensional frameworks stabilized by both argentophilic (or aurophilic) interactions and interligand C=O···HC H-bonds. Despite the interpenetration of the networks, these compounds display accessible void volume capable of hosting up to five mols. of MeOH which interact with the host pina ligand and establish an infinite lattice of H bonds along the structural channels. The magnetic studies showed that solvated complexes 1·xMeOH and 2·xMeOH display two- and four-step hysteretic thermally driven spin transitions, resp. However, when these compounds lose the MeOH mols., the magnetic behavior changes drastically giving place to gradual spin conversions evidencing the relevant influence of the guest mols. on the spin-crossover properties. Importantly, since the solvent desorption takes place following a single-crystal-to-single-crystal transformation, empty structures 1 and 2 (x = 0) could be also determined allowing the authors to evaluate the correlation between the structural changes and the modification of the magnetic properties triggered by the loss of MeOH mols. After reading the article, we found that the author used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Name: N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Name: N-(Pyridin-4-yl)isonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 1. Pyridine-containing stilbenes and amides》 were Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Geahlen, Robert L.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 1991. Related Products of 64479-78-3 The author mentioned the following in the article:

A series of pyridine-containing stilbene and amide derivatives based on the structure of piceatannol, a naturally occurring protein-tyrosine kinase inhibitor, were prepared and tested for inhibition of p56lck. The most potent of these compounds (I) is a competitive inhibitor of p56lck with respect to ATO. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Related Products of 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Australian Journal of Chemistry included an article by Roxburgh, Matthew A. D.; Zaiter, Samantha; Hudson, Xina I. B.; Mullaney, Benjamin R.; Clements, John E.; Moubaraki, Boujemaa; Murray, Keith S.; Neville, Suzanne M.; Kepert, Cameron J.. Synthetic Route of C11H9N3O. The article was titled 《Structure and Magnetic Studies on a Series of Two-Dimensional Iron(II) Framework Materials with Varying Ligand Characteristics》. The information in the text is summarized as follows:

Targeting the general (4,4)-grid structural motif, the authors prepared seven new coordination polymers in the general family [Fe(NCX)2(L)2]·(guest) (L = bis-pyridyl-type bridging ligands; X = S, Se) as an extension of the well-established spin crossover framework (SCOF) family. In all cases, the (4,4)-grid topol. is formed by the bridging of octahedral Fe(II) sites in the equatorial plane by bis-pyridyl ligands of varying length, flexibility, and intermol. interaction capacity. In particular, the six ligands n-(4-pyridyl)isonicotinamide (pin), trans-1,2-bis(4-pyridyl)ethene (tvp), 1,2-dibromo-1,2-bis(4-pyridyl)ethane (dbbpe), bis(4-pyridyl)-1,2,4,5-tetrazine (bptz), 4,4′-bis(pyridyl)acetylene (bpac), and 1,4-bis(4-pyridylethynyl)benzene (bpeben) were used. The seven complexes, [Fe(NCS)2(pin)2]·2(MeCN) (pin-S), [Fe(tvp)2(NCS)2]·1/2(tvp)·(CH2CH2OH) (tvp-S), [Fe(dbbpe)2(NCS)2]·6(CH3CN) (dbbpe-S), [Fe(NCS)2(bptz)2]·2(CHCl3)·6(H2O) (bptz-S), [Fe(NCSe)2(bptz)2]·4(CHCl3)·(EtOH)·(H2O) (bptz-Se), [Fe(NCS)2(bpac)2]·2(PrOH) (bpac-S), and [Fe(NCS)2(bpeben)2]·2(CHCl3) (bpeben-S) all form (4,4)-grids of varying size that are arranged in a parallel stacked topol. Despite being in the [FeN6] coordination environment known to be conducive to spin crossover, these materials all remain high-spin with thermal variation. These results are discussed in context with the large family of SCOFs that show varied spin crossover behaviors. The results came from multiple reactions, including the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Synthetic Route of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Synthetic Route of C11H9N3O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kondo, Mitsuru; Okubo, Takashi; Asami, Akiko; Noro, Shin-Ichiro; Yoshitomi, Tomomichi; Kitagawa, Susumu; Ishii, Tomohiko; Matsuzaka, Hiroyuki; Seki, Kenji published an article on January 15 ,1999. The article was titled 《Rational synthesis of stable channel-like cavities with methane gas adsorption properties: [{Cu2(pzdc)2(L)}n] (pzdc = pyrazine-2,3-dicarboxylate; L =a pillar ligand)》, and you may find the article in Angewandte Chemie, International Edition.Application of 64479-78-3 The information in the text is summarized as follows:

Porous coordination networks were designed in prepared copper complexes [{Cu2(pzdc)2(L)}n] (pzdc = pyrazine-2,3-dicarboxylate; L = pillar ligand pyrazine, 4,4′-bipyridyl, N-4-pyridinyl-4-pyridinecarboxamide). The structure of [{Cu2(pzdc)2(pyz)}.2H2O]n (1) was determined by x-ray crystallog. The complex consists of a pillared layer structure with a two-dimensional sheet of [Cu(pzdc)2]n and pillar pyrazine ligands that bridge each sheet. The channels are occupied by water mols. Thermal dehydration of 1 at 100-260° resulted in a stable phase which retained the porous network without decomposition (powder XRD study). Methane adsorption capabilities of the coordination networks were studied. Increased methane absorption activity for pillar ligands 4,4′-bipyridyl and N-4-pyridinyl-4-pyridinecarboxamide is consistent with the larger channel sizes of these complexes. The activity is comparable to that of zeolites and other reported stable porous coordination networks. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Application of 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《3D Printed High-Throughput Hydrothermal Reactionware for Discovery, Optimization, and Scale-Up》 was published in Angewandte Chemie, International Edition in 2014. These research results belong to Kitson, Philip J.; Marshall, Ross J.; Long, Deliang; Forgan, Ross S.; Cronin, Leroy. Quality Control of N-(Pyridin-4-yl)isonicotinamide The article mentions the following:

3D printing techniques allow the laboratory-scale design and production of reactionware tailored to specific exptl. requirements. To increase the range and versatility of reactionware devices, sealed, monolithic reactors suitable for use in hydrothermal synthesis were digitally designed and realized. The fabrication process allows the introduction of reaction mixtures directly into the reactors during the production, and also enables the manufacture of devices of varying scales and geometries unavailable in traditional equipment. The utility of these devices is shown by the use of 3D printed, high-throughput array reactors to discover two new coordination polymers, optimize the synthesis of one of these, and scale-up its synthesis using larger reactors produced on the same 3D printer. Reactors were also used to produce phase-pure samples of coordination polymers MIL-96 and HKUST-1, in yields comparable to synthesis in traditional apparatusN-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Quality Control of N-(Pyridin-4-yl)isonicotinamide) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Quality Control of N-(Pyridin-4-yl)isonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Qin, Zengquan; Jennings, Michael C.; Puddephatt, Richard J. published their research in Chemical Communications (Cambridge, United Kingdom) on December 21 ,2001. The article was titled 《Stacked molecular triangles: self-assembly using coordination chemistry and hydrogen bonding》.HPLC of Formula: 64479-78-3 The article contains the following contents:

The combination of the cis-blocked platinum(II) unit (bu2bipy)Pt2+ with the unsym. bis(pyridine) ligand 4-NC5H4C(:O)NH-4-C5H4N (L) gives the mol. triangle complex [{Pt(bu2bipy)(μ-L)}3]6+, which forms stacked pairs in the solid state through intertriangle NH···OC hydrogen bonds and Pt···OC secondary bonds. The crystal structure of [{(bu2bipy)Pt(μ-L)}3](CF3SO3)6·Me2CO·3H2O was determined The analogous palladium(II) complex was prepared as the BF4- salt.N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3HPLC of Formula: 64479-78-3) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. HPLC of Formula: 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Different Metal Aggregation in Copper Acetate Chain Coordination Polymers with Dipyridyl Tethers Bearing Hydrogen Bonding Capable Functional Groups》 were Uebler, Jacob W.; Stone, Brandon S.; LaDuca, Robert L.. And the article was published in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2013. Recommanded Product: N-(Pyridin-4-yl)isonicotinamide The author mentioned the following in the article:

Hydrothermal synthesis has afforded a pair of divalent copper acetate coordination polymers containing either 4,4′-dipyridylamine (dpa) or 4-pyridylisonicotinamide (4-pina), both of which have H-bonding-capable central functional groups. X-ray crystallog. revealed that both exhibit a 1-dimensional chain structure. Use of the kinked tethering ligand dpa produced [Cu(OAc)2(dpa)]n (1), which possesses a simple chain based on dpa linkage of isolated Cu ions. However, employing the straighter amide ligand 4-pina generated {[Cu(OAc)2(4-pina)]·0.5H2O}n (2), which exhibits {Cu2O2} rhomboid dimers formed through bridging acetate ligands. Weak antiferromagnetic coupling [g = 1.984(3), J = -3.2(3) cm-1] was observed within the axial-equatorial bridged {Cu2O2} dimers in 2, with possible ferrimagnetism due to spin canting <11 K.N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Recommanded Product: N-(Pyridin-4-yl)isonicotinamide) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Recommanded Product: N-(Pyridin-4-yl)isonicotinamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Uebler, Jacob W.; LaDuca, Robert L. published an article in Acta Crystallographica, Section E: Structure Reports Online. The title of the article was 《Diaquabis[N-(pyridin-4-yl)isonicotinamide-κN]bis(thiocyanato-κN)cobalt(II)》.Synthetic Route of C11H9N3O The author mentioned the following in the article:

In the title compound, [Co(NCS)2(C11H9N3O)2(H2O)2], the octahedrally coordinated CoII ion lies on a crystallog. inversion center and is bound by two isothiocyanate ligands, two aqua ligands and two N-(pyridin-4-yl)isonicotinamide (4-pina) ligands. The dihedral angle between the aromatic rings in the 4-pina ligand is 8.98(11)°. In the crystal, the individual mol. units are aggregated in three dimensions by O-H···N, O-H···S, and N-H···S hydrogen bonds. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Synthetic Route of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Synthetic Route of C11H9N3O The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics