Category: 64479-78-3

Recommanded Product: 64479-78-3On May 1, 2016 ,《Unsubstituted and substituted copper malonate coordination polymers with isomeric dipyridylamide ligands: Chain, layer, diamondoid, and self-penetrated topologies》 appeared in Inorganica Chimica Acta. The author of the article were Stone, Brandon S.; Staples, Richard J.; LaDuca, Robert L.. The article conveys some information:

Six dual-ligand divalent Cu malonate coordination polymers were prepared via solvent diffusion methods, and structurally characterized by single-crystal x-ray diffraction. The resulting dimensionality and topol. depend crucially on the steric bulk of the malonate ligand and the N donor disposition within the dipyridylamide coligand. {[Cu(mal)(3-pina)(H2O)]·2H2O}n (1, mal = malonate, 3-pina = 3-pyridylisonicotinamide) possesses a simple 1-dimensional chain structure, while the isomeric 4-pyridylnicotinamide (4-pna) ligand afforded a 2-fold interpenetrated (6,3) grid layer structure in {[Cu(mal)(4-pna)(H2O)]·3H2O}n (2). Employing Cu dimethylmalonate (dmmal) in the synthetic regime permitted synthesis of the (4,4) grid layered phase {[Cu2(dmmal)2(4-pna)2(H2O)3]·7H2O}n (3) and {[Cu2(dmmal)2(3-pina)2]·9.5H2O}n (4), which exhibited a 3-fold interpenetrated diamondoid net with large H2O-filled incipient channels, built from [Cu4(dmmal)4] tetranuclear clusters. {[Cu2(Hdmmal)2(dmmal)(4-pina)2]·0.5H2O}n (5, 4-pina = 4-pyridylisonicotinamide) manifested a unique 5-connected self-penetrated 3-dimensional network with 42678 topol. {[Cu(emal)(4-pna)(H2O)]·3H2O}n (6, emal = ethylmalonate) is another simple 1-dimensional chain phase. Ferromagnetic coupling (J = 11(3) cm-1) was observed within the tetranuclear clusters in 4. Thermal properties of these materials are also presented. In the experiment, the researchers used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Recommanded Product: 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Recommanded Product: 64479-78-3Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2015,Chemistry – A European Journal included an article by De, Dinesh; Neogi, Subhadip; Sanudo, E. Carolina; Bharadwaj, Parimal K.. Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide. The article was titled 《Single-Crystal to Single-Crystal Linker Substitution, Linker Place Exchange, and Transmetalation Reactions in Interpenetrated Pillared-Bilayer Zinc(II) Metal-Organic Frameworks》. The information in the text is summarized as follows:

A 2-fold interpenetrated pillared-bilayer framework, {[Zn3(L)2(L2)(DMF)]·(18DMF)(6H2O)}n (1), was synthesized from the ligands tris(4′-carboxybiphenyl)amine (H3L) and 1,2-bis(4-pyridyl)ethylene (L2). The structure contains [Zn3(COO)6] secondary building units (SBUs), in which three ZnII ions are almost linear with carboxylate bridging. This framework undergoes reversible pillar linker substitution reactions at the terminal ZnII centers with three different dipyridyl linkers of different lengths to afford three daughter frameworks, 2-4. Frameworks 2-4 are interconvertible through reversible linker substitution reactions. Also, competitive linker-exchange experiments show preferential incorporation of linker L3 in the parent framework 1. The larger linker L5 does not undergo such substitution reactions and framework 5, which contains this linker, can be synthesized solvothermally as a 2-fold interpenetrated structure. When framework 5 is dipped in a solution of L3 in DMF, linker substitution takes place as before, but linker L5 now moves and diagonally binds two ZnII centers to afford 6 as a nonpenetrated single framework. This linker place exchange reaction is unprecedented. All of these reactions take place in a single-crystal to single-crystal (SC-SC) manner, and were observed directly through x-ray crystallog. Each 3D framework undergoes complete copper(II) transmetalation. After reading the article, we found that the author used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Systematic evaluation of textural properties, activation temperature and gas uptake of Cu2(pzdc)2L [L = dipyridyl-based ligands] porous coordination pillared-layer networks》 was published in Dalton Transactions in 2012. These research results belong to Garcia-Ricard, Omar J.; Silva-Martinez, Juan C.; Hernandez-Maldonado, Arturo J.. Category: amides-buliding-blocks The article mentions the following:

In situ high temperature x-ray diffraction, nitrogen porosimetry and gas adsorption at room temperature were used to elucidate the effect of the degassing or activation temperature on the long-range and micropore textural properties of a series of coordination polymers with pillared-layer structures. Ramp-and-soak TGA performed at selected activation temperatures were used to verify the thermal stability of a CPL-n series [Cu2(pzdc)2L; H2pzdc = pyrazine-2,3-dicarboxylic acid; L = 4,4′-azopyridine (apy) for CPL-4, 1,2-bis(4-pyridyl)ethylene (bpe) for CPL-5, N-(4-pyridyl)isonicotinamide (pia) for CPL-6, and 1,2-bis(4-pyridyl)glycol (dpyg) for CPL-7]. Although the activation temperatures were far below the decomposition point of the complexes, these resulted in significant and unique changes in micropore surface area and volume, even for CPL-4, -5 and -6, which contained pillar ligands with similar dimensions and similar structural long-range order. For the case of CPL-7, however, the framework appeared to be non-porous at any given activation temperature Pure component equilibrium adsorption data gathered for CO2, CH4, and N2 were used to elucidate the CPL-n materials potential for storage and separations at room temperature All of the materials exhibited considerable selectivity toward CO2, particularly at moderate pressures. Meanwhile, CO2 isosteric heats of adsorption indicated that the pore functionalities arising from the pillar ligands provided similar interactions with the adsorbate in the cases of CPL-4 and -5. For CPL-6, the presence of the carbonyl (C:O) group appeared to enhance interactions with CO2 at low loadings. After reading the article, we found that the author used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Category: amides-buliding-blocks)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 64479-78-3On March 8, 2012, Li, Rongshi; Martin, Mathew P.; Liu, Yan; Wang, Binglin; Patel, Ronil A.; Zhu, Jin-Yi; Sun, Nan; Pireddu, Roberta; Lawrence, Nicholas J.; Li, Jiannong; Haura, Eric B.; Sung, Shen-Shu; Guida, Wayne C.; Schonbrunn, Ernst; Sebti, Said M. published an article in Journal of Medicinal Chemistry. The article was 《Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors》. The article mentions the following:

Using high concentration biochem. assays and fragment-based screening assisted by structure-guided design, we discovered a novel class of Rho-kinase inhibitors. Compound 18 (I) was equipotent for ROCK1 (IC50 = 650 nM) and ROCK2 (IC50 = 670 nM), whereas compound 24 was more selective for ROCK2 (IC50 = 100 nM) over ROCK1 (IC50 = 1690 nM). The crystal structure of the compound 18-ROCK1 complex revealed that 18 is a type 1 inhibitor that binds the hinge region in the ATP binding site. Compounds 18 and 24 inhibited potently the phosphorylation of the ROCK substrate MLC2 in intact human breast cancer cells. In the experiment, the researchers used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Related Products of 64479-78-3 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Constructions of 2D-Metallamacrocycles Using Half-Sandwich RuII2 Precursors: Synthesis, Molecular Structures, and Self-Selection for a Single Linkage Isomer》 was written by Shanmugaraju, Sankarasekaran; Bar, Arun Kumar; Joshi, Sachin A.; Patil, Yogesh P.; Mukherjee, Partha Sarathi. Related Products of 64479-78-3 And the article was included in Organometallics on April 11 ,2011. The article conveys some information:

Coordination-driven self-assembly of oxalato-bridged half-sandwich p-cymene Ru complex [Ru2(μ-η4-C2O4)(MeOH)2(η6-p-cymene)2](O3SCF3)2 (1a) with several ditopic donors (La-Ld) in MeOH affords bi- and tetranuclear metallamacrocycles (2a and 3-5). Similarly, the combination of 2,5-dihydroxy-1,4-benzoquinonato (dhbq)-bridged binuclear complex [Ru2(μ-η4-C6H2O4)(MeOH)2(η6-p-cymene)2](O3SCF3)2 (1b) with a flexible bidentate amide linker (La) in 1:1 molar ratio gave the corresponding tetranuclear complex 2b. All the macrocycles were isolated as their triflate salts in high yields and were fully characterized by various spectroscopic techniques. Finally, the mol. structures of all the assemblies were determined unambiguously by single-crystal X-diffraction anal. The combination of acceptor 1a or 1b with an unsym. linear ditopic donor La results in a self-sorted linkage isomeric (head-to-tail) macrocycle (2a or 2b) despite the possibility of formation of two different isomeric macrocycles (head-to-head or head-to-tail) due to different connectivity of the donor. Mol. structures of the complexes 2a and 2b showed tetranuclear rectangular geometry with dimensions of 5.51 Å × 13.29 Å for 2a and 7.91 Å × 13.46 Å for 2b. In both cases, two binuclear RuII2 building blocks are connected by a μ-N-(4-pyridyl)isonicotinamide donor in a head-to-tail fashion. Surprisingly, the macrocycle 2a loses one counteranion and cocrystallizes with monodeprotonated 1,3,5-trihydroxybenzene via strong intermol. π-π stacking and H bonding. The tweezer complex 3 showed strong fluorescence in solution, and it showed fluorescence sensing toward nitroarom. compounds A fluorescence study demonstrated a marked quenching of the initial fluorescence intensity of the macrocycle 3 upon gradual addition of trinitrotoluene and exhibits significant fluorescence quenching response only for nitroarom. compounds compared to various other aromatic compounds tested. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Related Products of 64479-78-3 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Structural Diversity in Multinuclear PdII Assemblies that Show Low-Humidity Proton Conduction》 was published in Chemistry – A European Journal in 2014. These research results belong to Samanta, Dipak; Mukherjee, Partha Sarathi. SDS of cas: 64479-78-3 The article mentions the following:

Systematic study on synergetic effects of geometry, length, denticity, and asymmetry of donors was performed through the formation of uncommon PdII aggregates by employing the donor in a multicomponent self-assembly of a cis-blocked 90° PdII acceptor and a tetratopic donor. Some of these assemblies represent the 1st examples of these types of structures, and their formation is not anticipated by only taking the geometry of the donor and the acceptor building units into account. Anal. of the crystal packing of the x-ray structure revealed several H bonds between the counteranions (NO3-) and H2O mols. (O-H···O=N). Also, H-bonded 3-dimensional-networks of H2O are present in the mol. pockets, which show H2O-adsorption properties with some variation in H2O affinity. These complexes exhibit proton conductivity (1.87 × 10-5-6.52 × 10-4 Scm-1) at 296 K and low relative humidity (∼46 %) with activation energies of 0.29-0.46 eV. Also, the conductivities further increase with the enhancement of humidity. The ability of these assemblies to exhibit p-conducting properties under low-humidity conditions makes these materials highly appealing as electrolytes in batteries and in fuel-cell applications. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3SDS of cas: 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.SDS of cas: 64479-78-3 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Molecular Hydrogels from Bolaform Amino Acid Derivatives: A Structure-Properties Study Based on the Thermodynamics of Gel Solubilization》 was published in Chemistry – A European Journal in 2012. These research results belong to Nebot, Vicent J.; Armengol, Jose; Smets, Johan; Prieto, Susana Fernandez; Escuder, Beatriu; Miravet, Juan F.. COA of Formula: C11H9N3O The article mentions the following:

Insight is provided into the aggregation thermodn. associated with hydrogel formation by mol. gelators derived from L-valine and L-isoleucine. Solubility data from NMR measurements are used to extract thermodn. parameters for the aggregation in water. At room temperature and up to 55°C, these systems form self-assembled fibrillar networks in water with quite low or zero enthalpic component, whereas the entropy of the aggregation is favorable. These results are explained by considering that the hydrophobic effect is dominant in the self-assembly. However, studies by NMR and IR spectroscopy reveal that intermol. hydrogen bonding is also a key issue in the aggregation process of these mols. in water. The low enthalpy values measured for the self-assembly process are ascribed to the result of a compensation of the favorable intermol. hydrogen-bond formation and the unfavorable enthalpy component of the hydrophobic effect. Addnl., by using the hydrophobic character as a design parameter, enthalpy-controlled hydrogel formation, as opposed to entropy-controlled hydrogel formation, can be achieved in water if the gelator is polar enough. It is noteworthy that these two types of hydrogels, enthalpy- vs. entropy-driven hydrogels, present quite different response to temperature changes in properties such as the min. gelator concentration or the rheol. moduli. Finally, the presence of a polymorphic transition in a hydrogel upon heating above 70°C is reported and ascribed to the weakening of the hydrophobic effect upon heating. The new soft polymorphic materials present dramatically different solubility and rheol. properties. Altogether these results are aimed to contribute to the rational design of mol. hydrogelators, which could be used for the tailored preparation of this type of soft materials. The reported results could also provide ground for the rationale of different self-assembly processes in aqueous media. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3COA of Formula: C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.COA of Formula: C11H9N3O The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Zipped-up chain-type coordination polymers: unsymmetrical amide-containing ligands inducing β-sheet or helical structures》 was written by Uemura, Kazuhiro; Kumamoto, Yuki; Kitagawa, Susumu. Recommanded Product: 64479-78-3 And the article was included in Chemistry – A European Journal in 2008. The article conveys some information:

The crystal structures of thirteen AgI coordination polymers involving py-CONH-(CH2)n-py (py = pyridine; n = 0, 1) derivatives were determined by single-crystal x-ray analyses. All of the compounds form 1-dimensional chains composed of AgI atoms and bridging ligands {[Ag(py-CONH-(CH2)n-py)][X]}n (X = PF6-, ClO4-, BF4-, and NO3- with solvent mols.). The unsym. coordination environments around AgI atoms induce direction in the chains, i.e., -[NH-(CH2)n-py-Ag-py-CO]-, which resembles the alignment of amino acid chains in proteins. In {[Ag(4-pia)][X]}n (1 ⊃ X; 4-pia = N-(4-pyridyl)isonicotinamide; X = PF6-, ClO4-, BF4-, and NO3-), {[Ag(4-pmia)][X]}n (2 ⊃ X; 4-pmia = N-(pyridin-4-ylmethyl)isonicotinamide; X = PF6-, ClO4-·H2O, and NO3-·H2O), and {[Ag(3-pmia)][X]}n (3 ⊃ X; 3-pmia = N-(pyridin-3-ylmethyl)isonicotinamide; X = PF6-, ClO4-, BF4-, and NO3-·H2O), each chain is aligned parallel to neighboring chains, but adjacent chains run in the opposite direction. Particularly in {[Ag(3-pmia)]-[PF6]}n (3 ⊃ PF6-), {[Ag(3-pmia)][ClO4]}n (3 ⊃ ClO4-), and {[Ag(3-pmia)][BF4]}n (3 ⊃ BF4-), amide moieties of 3-pmia ligands are complementarily H bonded to amide moieties in neighboring chains, as in the β-sheet motif in proteins. However, in {[Ag(4-pmna)][PF6]·MeOH}n (4-pmna = N-(pyridin-4-ylmethyl)nicotinamide), all chains in the crystal form left-handed (4a ⊃ PF6-·MeOH) and right-handed (4b ⊃ PF6-·MeOH) helical structures with a helical pitch of 28 Å. Heterogeneous anion exchanges proceed reversibly in 2, but not in 3, which provides information about the thermal stabilities of the crystals. The results came from multiple reactions, including the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Recommanded Product: 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Recommanded Product: 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C11H9N3OOn June 3, 2020, Riascos-Rodriguez, Karina; Marks, Samuel; Evans, Paul G.; Hernandez-Rivera, Samuel P.; Ruiz-Caballero, Jose L.; Pinero, Dalice; Hernandez-Maldonado, Arturo J. published an article in Crystal Growth & Design. The article was 《Lithium Functionalization Promoted by Amide-Containing Ligands of a Cu(pzdc)(pia) Porous Coordination Polymer for CO2 Adsorption Enhancement》. The article mentions the following:

A pillared layer network containing amide functional groups (Cu(pzdc)(pia); pzdc = pyrazine-2,3-dicarboxylate; pia = N-(4-pyridyl)isonicotinamide) was used to test a postsynthesis metalation rationale to insert lithium and create a porous surface with enhanced CO2 adsorption capacity. Synchrotron powder X-ray diffraction (XRD) was used to determine variations after lithiation in long-range and textural properties. CO2 adsorption measurements at room temperature showed a concave up isotherm shape with an increasing adsorption at high pressures, surpassing by 1 order of magnitude the values previously reported for the unmodified material. There was significant hysteresis upon desorption, which suggests structural variations consequent to different or stronger adsorption sites. Results from elemental, thermal gravimetric, and crystal refinement analyses indicate that the lithium content is ca. 3 Li atoms per asym. unit. Raman scattering showed N-Li and Li-O stretching bands, a shift of pia amide- and pyridyl-related bands, and other significant skeletal vibrations associated with nitrogen and oxygen lone pair variations. In situ XRD and CO2 adsorption observations at up to 50 bar at ambient temperature were consistent with the anticipated structural dynamic variation. The lattice changes observed at pressures below 10 bar following lithiation may be directly related to an enhancement in the CO2 adsorption amount The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Synthetic Route of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Synthetic Route of C11H9N3O Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Coordination-driven self-assembly of 2D-metallamacrocycles using a shape-selective PtII2-organometallic 90° acceptor: design, synthesis and sensing study》 were Shanmugaraju, Sankarasekaran; Samanta, Dipak; Gole, Bappaditya; Mukherjee, Partha Sarathi. And the article was published in Dalton Transactions in 2011. Reference of N-(Pyridin-4-yl)isonicotinamide The author mentioned the following in the article:

Synthesis of two-dimensional metallamacrocycles via coordination-driven self-assembly of a shape-selective Pt(II)2-mol. building unit incorporating carbazole-ethynyl functionality is described. An equimolar (1:1) combination of a Pt(II)2-organometallic 90° acceptor, 3,6-bis[trans-Pt(PEt3)2(NO3)(ethynyl)]carbazole (1), with rigid linear ditopic donors La (La = 4,4′-bipyridine) and Lb (Lb = trans-1,2-bis(4-pyridyl)ethylene) afforded the corresponding [4 + 4] self-assembled octanuclear mol. squares in quant. yields. Conversely, a similar treatment of 1 with amide-based unsym. flexible ditopic donor, Lc (Lc = N-(4-pyridyl)isonicotinamide), gave a [2 + 2] self-sorted mol. rhomboid as a single product. Despite the possibility of several linkage isomeric macrocycles (rhomboid, triangle and square) due to the different connectivity of Lc, the formation of a single and sym. mol. rhomboid as the only product is an interesting observation. All the self-assembled macrocycles were fully characterized by multinuclear NMR (1H and 31P) and ESI-MS anal. Further structural insights about the size and shape of the macrocycles were obtained through energy minimization using d. functional theory (DFT) calculations Decoration of the starting carbazole building unit with Pt-ethynyl functionality enriches the assemblies to be more π-electron rich and luminescent in nature. The two octanuclear mol. squares could sense the presence of electron deficient nitroaroms. in solution by fluorescence quenching of the initial intensity upon addition They exhibited the largest quenching response with high selectivity for nitroaroms. compared to several other electron deficient aromatics tested. In the experiment, the researchers used many compounds, for example, N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Reference of N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Reference of N-(Pyridin-4-yl)isonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics