Category: 640-61-9

Adding a certain compound to certain chemical reactions, such as: 640-61-9, name is N,4-Dimethylbenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 640-61-9, Product Details of 640-61-9

The reaction mixture, which was prepared from Bromoethynylbenzene (1.38 g, 7.31mmol), N-Methyl-p-toluenesulfonamide (1.23 g, 6.65 mmol), K2CO3 (1.83 g, 13.3mmol), CuSO4?5H2O (0.17 g, 0.66 mmol) and 1,10-Phenanthroline (0.24 g, 1.33mmol) in Toluene (8 mL), was stirred at 60 C for 40 h. After cooled to rt, the resulting mixture was filtered on celite, and the volatiles were removed under reduce pressure. The residue was separated by column chromatograpy on silica gel(Hexane/EtOAc = 3:1) to provide 1f (1.74 g, 92%). IR (KBr) nu 2233, 1339, 1189 cm-1; 1H NMR (400 MHz, CDCl3) delta 2.46 (s, 3H), 3.15(s, 3H), 7.07-7.32 (m, 3H), 7.32-7.64 (m, 4H) 7.84 (d, J = 8.2 Hz, 2H); 13C NMR(100 MHz, CDCl3) delta 21.6, 39.2, 68.9, 83.9, 122.6, 127.7, 127.8, 128.2, 129.7, 131.3,133.1, 144.8; EI-LRMS m/z 285 (M+), 130, 105, 89; EI-HRMS m/z calcd for C16H15NO2S (M+) 285.0823, found 285.0817.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,4-Dimethylbenzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wakamatsu, Hideaki; Yanagisawa, Rika; Kimura, Sho; Osawa, Nao; Natori, Yoshihiro; Yoshimura, Yuichi; Synlett; vol. 28; 16; (2017); p. 2135 – 2138;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 640-61-9,Some common heterocyclic compound, 640-61-9, name is N,4-Dimethylbenzenesulfonamide, molecular formula is C8H11NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared according to the general procedures. 1) Tube reactorwith 4 static mixers, a 6 mL reactor volume and a residencetime of 3 min, 1.5 M NaOCl (aq) at 1 mL/min and 1 MN-benzylmethylamine in EtOAc at 1 mL/min. 2) CSTR with a reactor volume of 50 mL, and residence time of 25 min. 1.1 MNaOCl (aq) at 1 mL/min and 1 M N-benzylmethylamine intoluene at 1 mL/min were used. The product was isolated foreach reactor volume by separation of the organic phase for eachreactor volume of solution and removal of the solvent by rotaryevaporation to give a white solid (1 reactor volume gives666 mg, 3.0 mmol, quantitative yield). NMR data matches thatreported in the literature [37]. 1H NMR (CDCl3, 500 MHz) deltappm 7.82 (d, J = 8.4 Hz, 2H, CHAr), 7.42 (d, J = 8.4 Hz, 2H,CHAr), 3.09 (s, 3H, NCH3), 2.48 (s, 3H, Ar-CH3); 13C NMR(CDCl3, 125 MHz) delta ppm 145.75 (CAr), 129.80 (2CHAr),129.78 (2 CHAr), 128.28 (CAr), 45.51 (NCH3), 21.70 (ArCH3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,4-Dimethylbenzenesulfonamide, its application will become more common.

Reference:
Article; Blacker, A. John; Jolley, Katherine E.; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 2408 – 2417;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 640-61-9 as follows. HPLC of Formula: C8H11NO2S

Add 0.2 mmol of N-methyl-p-toluenesulfonamide and a stirrer to a clean Schlenk reaction tube.Then, 1.0 mL of DMF solvent was added by syringe, and 1.0 mmol of NaOH was added to the reaction tube.Finally, 0.6 mmol of 1,1-dichloroethylene was added with a micro syringe, and the bottle was stoppered with a soft rubber stopper, and reacted at 70 C for 24 hours.TLC dot plate detection; after the reaction is completed, the reaction solution is added with ice water and extracted with ethyl acetate three times.The organic layer is concentrated and separated by column chromatography to obtain pure N-methyl-N-ethynyl p-toluenesulfonamide.White solid, yield 93%.

According to the analysis of related databases, 640-61-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangxi Normal University; Zhao Junfeng; Tu Yongliang; Zeng Xianzhu; (9 pag.)CN109320441; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 640-61-9,Some common heterocyclic compound, 640-61-9, name is N,4-Dimethylbenzenesulfonamide, molecular formula is C8H11NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared according to the general procedures. 1) Tube reactorwith 4 static mixers, a 6 mL reactor volume and a residencetime of 3 min, 1.5 M NaOCl (aq) at 1 mL/min and 1 MN-benzylmethylamine in EtOAc at 1 mL/min. 2) CSTR with a reactor volume of 50 mL, and residence time of 25 min. 1.1 MNaOCl (aq) at 1 mL/min and 1 M N-benzylmethylamine intoluene at 1 mL/min were used. The product was isolated foreach reactor volume by separation of the organic phase for eachreactor volume of solution and removal of the solvent by rotaryevaporation to give a white solid (1 reactor volume gives666 mg, 3.0 mmol, quantitative yield). NMR data matches thatreported in the literature [37]. 1H NMR (CDCl3, 500 MHz) deltappm 7.82 (d, J = 8.4 Hz, 2H, CHAr), 7.42 (d, J = 8.4 Hz, 2H,CHAr), 3.09 (s, 3H, NCH3), 2.48 (s, 3H, Ar-CH3); 13C NMR(CDCl3, 125 MHz) delta ppm 145.75 (CAr), 129.80 (2CHAr),129.78 (2 CHAr), 128.28 (CAr), 45.51 (NCH3), 21.70 (ArCH3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,4-Dimethylbenzenesulfonamide, its application will become more common.

Reference:
Article; Blacker, A. John; Jolley, Katherine E.; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 2408 – 2417;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 640-61-9, name is N,4-Dimethylbenzenesulfonamide, A new synthetic method of this compound is introduced below., SDS of cas: 640-61-9

General procedure: To a mixture of the corresponding sulfonamide (5 mmol), DMAP (0.5 mmol%)and Et3N (1.5 mL, 10 mmol) in CH2Cl2 (10 mL) was added slowly the acyl chloride made above in CH2Cl2 (10 mL) at 0C. The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was washed with 5% HCl, brine and H2O. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure to give crude product, which was purified by column chromatography on silica gel to afford N-tosylcarboxylic amide.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Chen; Huang, Lingyun; Wang, Fengze; Zou, Gang; Tetrahedron Letters; vol. 59; 23; (2018); p. 2299 – 2301;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 640-61-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 640-61-9, name is N,4-Dimethylbenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a resealable Schlenk tube was added Fe3O4SiO2-P-AuOTf (66 mg, 0.025 mmol). The reaction tubewas evacuated and back-filled with argon and this evacuation/back-fillprocedure was repeated one additional time. Alkynylcyclopropane(0.5 mmol), sulfonamide (0.6 mmol) and DCE (5 mL) were then addedunder a stream of argon. The reaction tube was quickly sealed and thecontents were stirred while heating in an oil bath at 100 C for 24 h. After thereaction mixture was cooled to room temperature, the supported goldcatalyst was magnetically separated and the reaction mixture wasconcentrated under vacuum and then purified by flash chromatography(petroleum ether/ethyl acetate = 7:1) to afford the corresponding product.The recovered gold catalyst was washed with DCE (2 2 mL), air-dried andused directly for the next run.

The chemical industry reduces the impact on the environment during synthesis N,4-Dimethylbenzenesulfonamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yi, Feiyan; Huang, Bin; Nie, Quan; Cai, Mingzhong; Tetrahedron Letters; vol. 57; 39; (2016); p. 4405 – 4410;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 640-61-9, name is N,4-Dimethylbenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 640-61-9, category: amides-buliding-blocks

The reaction mixture, which was prepared from Bromoethynylbenzene (1.38 g, 7.31mmol), N-Methyl-p-toluenesulfonamide (1.23 g, 6.65 mmol), K2CO3 (1.83 g, 13.3mmol), CuSO4?5H2O (0.17 g, 0.66 mmol) and 1,10-Phenanthroline (0.24 g, 1.33mmol) in Toluene (8 mL), was stirred at 60 C for 40 h. After cooled to rt, the resulting mixture was filtered on celite, and the volatiles were removed under reduce pressure. The residue was separated by column chromatograpy on silica gel(Hexane/EtOAc = 3:1) to provide 1f (1.74 g, 92%). IR (KBr) nu 2233, 1339, 1189 cm-1; 1H NMR (400 MHz, CDCl3) delta 2.46 (s, 3H), 3.15(s, 3H), 7.07-7.32 (m, 3H), 7.32-7.64 (m, 4H) 7.84 (d, J = 8.2 Hz, 2H); 13C NMR(100 MHz, CDCl3) delta 21.6, 39.2, 68.9, 83.9, 122.6, 127.7, 127.8, 128.2, 129.7, 131.3,133.1, 144.8; EI-LRMS m/z 285 (M+), 130, 105, 89; EI-HRMS m/z calcd for C16H15NO2S (M+) 285.0823, found 285.0817.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,4-Dimethylbenzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wakamatsu, Hideaki; Yanagisawa, Rika; Kimura, Sho; Osawa, Nao; Natori, Yoshihiro; Yoshimura, Yuichi; Synlett; vol. 28; 16; (2017); p. 2135 – 2138;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

640-61-9, The chemical industry reduces the impact on the environment during synthesis 640-61-9, name is N,4-Dimethylbenzenesulfonamide, I believe this compound will play a more active role in future production and life.

General procedure: To a mixture of the corresponding sulfonamide (5 mmol), DMAP (0.5 mmol%)and Et3N (1.5 mL, 10 mmol) in CH2Cl2 (10 mL) was added slowly the acyl chloride made above in CH2Cl2 (10 mL) at 0C. The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was washed with 5% HCl, brine and H2O. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure to give crude product, which was purified by column chromatography on silica gel to afford N-tosylcarboxylic amide.

The chemical industry reduces the impact on the environment during synthesis N,4-Dimethylbenzenesulfonamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Wang, Chen; Huang, Lingyun; Wang, Fengze; Zou, Gang; Tetrahedron Letters; vol. 59; 23; (2018); p. 2299 – 2301;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

640-61-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 640-61-9, name is N,4-Dimethylbenzenesulfonamide, A new synthetic method of this compound is introduced below.

To a solution of bromoethynylbenzene (1.4 g, 8.0 mmol) in 24 mL of anhydrous toluene in a reaction vial were added methyl phenylcarbamate (1.5 g, 9.6 mmol), K3PO4 (3.4 g, 16 mmol), copper sulfate-pentahydrate (400 mg, 16 mmol), and 1,10-phenanthroline (577 mg, 3.2 mmol). The reaction mixtures was capped under an argon atmosphere, and heated in an oil bath at 80 ?C for 15 h. The progress of the reaction was monitored using TLC analysis. Upon completion, the reaction mixture was allowed to cool to room temperature, and diluted with 15 mL of ethyl acetate. The mixture was filtered through a pad of celite, and the filtrate was concentrated in vacuo. The crude residue was purified by column chromatography with eluent of Hexane/ ethyl acetate = 19/1 to give 1.6 g of 1 in 80 % yield as a yellow oil. 1H NMR (400 MHz, CDCl3) delta 7.55 (dd, J = 1.2, 8.6 Hz, 2H), 7.45-7.40 (m, 4H), 7.33-7.28 (m, 4H), 3.92 (s, 3H). 13C NMR. (100 MHz, CDCl3) delta 154.9, 139.7, 131.5, 129.1, 128.4, 128.0, 127.2, 124.8, 123.0, 83.0, 70.3, 54.5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Sato, Akihiro H.; Ohashi, Kazuhiro; Iwasawa, Tetsuo; Tetrahedron Letters; vol. 54; 10; (2013); p. 1309 – 1311;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics