Application of 6329-26-6, These common heterocyclic compound, 6329-26-6, name is Ethyl (2-chloroethyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a) A mixture of 1-(4-bromophenyl)piperazine (0.018 mol) and ethyl (2-chloroethyl)-carbamate (0.036 mol) was stirred for 2 hours at 130 C. Triethylamine (3 ml) was added and the mixture was stirred for 15 minutes at 130 C. The reaction mixture was cooled to room temperature, CH2 Cl2 was added and the resulting mixture was washed with water. The organic layer was separated, dried, filtered and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2 Cl2 /CH3 OH 95/5). The pure fractions were collected and the solvent was evaporated, yielding 4.3 g (67.2%) of ethyl [2-[4-(4-bromophenyl)-1-piperazinyl]-ethyl]carbamate (interm. 1).
Statistics shows that Ethyl (2-chloroethyl)carbamate is playing an increasingly important role. we look forward to future research findings about 6329-26-6.
Reference:
Patent; Janssen Pharmaceutica, N.V.; US6103725; (2000); A;,
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