Category: 6292-59-7

Related Products of 6292-59-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6292-59-7 as follows.

c) A solution of 0.353 g of 4,6-dichloro-5-(2-methoxyphenoxy)-2-(thiophen-2-yl)-pyrimidine in 5 ml of DMSO was heated to 150° C. with 0.376 g of p-tert-butylbenzenesulphonamide for 30 minutes. The solution was concentrated in a high vacuum and the oily residue was poured on to ice, made acid (pH=3) and the suspension was extracted with ethyl acetate. The organic extracts were combined, washed with water, dried over sodium sulfate and concentrated under reduced pressure. The residue was chromatographed on silica gel with toluene-ethyl acetate 9:1 and yielded 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(thiophen-2-yl)-pyrimidin-4-yl]-benzenesulphonamide as a white foam.

According to the analysis of related databases, 6292-59-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoffmann-La Roche Inc.; US5292740; (1994); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 6292-59-7, A common heterocyclic compound, 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, molecular formula is C10H15NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20 By reacting 4,6-dichloro-5-[(2-methoxy-4-methyl)phenoxy]pyrimidine with p-t-butylbenzenesulfonamide and thereafter with ethylene glycol Na there was obtained p-t-butyl-N-[6-(2-hydroxyethoxy)-5-[(2-methoxy-p-tolyl)oxy]-4-pyrimidinyl]benzenesulfonamide as a solid.

The synthetic route of 6292-59-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US5292740; (1994); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6292-59-7, Safety of 4-(tert-Butyl)benzenesulfonamide

p-t-butyl benzene sulphonamide (2.2 g, 0.0104 mol) was taken in Dimethyl Sulphoxide and potassium carbonate was added (2.75 g, 0.0198 mol) under inter atmosphere and stirred for 0.5 h. 3.4 g of 4,6- dichloro 5-(2-methoxyphenoxy) [2,2]-bipyrimidinyl compound (formula-3) 3.44 g, 0.009 mol was added and heated to 120° C. and maintained at the same temperature for 2 h. The reaction mass was quenched in iN hydrochloric acid and stirred for 2 h. Product precipitates out and was filtered and washed with water and dried under vacuum yielding 4.3 g (9 6percent) of pale yellow crystalline solid 4,6- dichioro 5-(2-methoxyphenoxy) [2,2]- bipyrimidinyl compound of formula-3 having the X-ray diffraction pattern with peaks at 8.547, 9.867, 11.068, 11.97, 13.851, 14.726, 15.539, 17.213, 18.428, 20.463, 22.232, 22.704, 23.536,23.937, 24.827, 26.291, 26.545, 27.294, 27.815, 28.223,29.278, 30.022, 30.5, 31.447, 31.996, 32.454, 33.43, 33.644,34.251, 34.89, 35.662, 36.393, 37.402, 38.523, 39.022,40.238, 40.724, 41.35, 41.93, 43.732, 44.289, 45.24, 47.267, 47.978,49.123,49.438, 50.22, ±0.2 degrees two theta values.

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Reference:
Patent; Biocon Limited; Venkata, Srinivas Pullela; Kothakonda, Kiran Kumar; Rajmahendra, Shanmughasamy; Chandrasekaran, Indrajit; Kaliappan, Mariappan; Mailar, Rekha Shivappa; US2014/275535; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 6292-59-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of p-tert-butylbenzenesulfonamide (VI) (13.5 g, 63 mmol) was dissolved in sodium hydroxide solution (31.5 mL, 2N) and the solvent was distilled off under reduced pressure to give the sodium salt of p-tert-butylbenzenesulfonamide.A solution of tert-butylbenzenesulfonamide sodium and 4,6-dichloro-5- (2-methoxyphenoxy) -2,2 ‘-bipyridine (V) (21.05 g, 60.3 mmol) (200 mL) and heated to 90 ° C with stirring for 3 h. TLC was complete. The residue was diluted with IN hydrochloric acid and the pH was adjusted to 3 to 4 with IN hydrochloric acid. The crystals were recrystallized and dried under reduced pressure to give 29.5 g of a white solid as N- [6-chloro (2-methoxyphenoxy) [2,2 ‘] – dipyridyl] -4-yl] -4- (1,1-dimethylethyl) -benzenesulfonamide (W) The yield was 93percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(tert-Butyl)benzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Tianci International Pharmaceutical Co., Ltd.; Li Xinjuanzi; Li Jianzhi; Ma Xilai; Chi Wangzhou; Liu Hai; Hu Xuhua; Zheng Xiaoli; Zhai Zhijun; Li Jianxun; (14 pag.)CN104193687; (2017); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6292-59-7, Product Details of 6292-59-7

Process for conversion of compound (2) to (3) (stage 2)A mixture of DMSO (10 vol), potassium carbonate (1.2 eq), 4-tert-butyl phenyl sulfonamide (1 eq) and compound (2) (1 eq) was heated at 1200C for 10 hours. After completion of the reaction, water (25 vol) was added to the reaction mixture, the reaction mixture was acidified with a solution of tartaric acid (1.8 eq) in water (25 vol) to pH 3, and the precipitated solid was filtered under vacuum and dried under vacuum (lOmbar) at 500C for 2 hours. The product (compound (3)) was obtained as a light brown solid (molar yield = 100percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; WO2009/98517; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 6292-59-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6292-59-7 as follows.

c) A solution of 0.353 g of 4,6-dichloro-5-(2-methoxyphenoxy)-2-(thiophen-2-yl)-pyrimidine in 5 ml of DMSO was heated to 150° C. with 0.376 g of p-tert-butylbenzenesulphonamide for 30 minutes. The solution was concentrated in a high vacuum and the oily residue was poured on to ice, made acid (pH=3) and the suspension was extracted with ethyl acetate. The organic extracts were combined, washed with water, dried over sodium sulfate and concentrated under reduced pressure. The residue was chromatographed on silica gel with toluene-ethyl acetate 9:1 and yielded 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(thiophen-2-yl)-pyrimidin-4-yl]-benzenesulphonamide as a white foam.

According to the analysis of related databases, 6292-59-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoffmann-La Roche Inc.; US5292740; (1994); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, SDS of cas: 6292-59-7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6292-59-7, Name is 4-(tert-Butyl)benzenesulfonamide, molecular formula is C10H15NO2S. In an article, author is Guo, Xuliang,once mentioned of 6292-59-7.

The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.

If you’re interested in learning more about 6292-59-7. The above is the message from the blog manager. SDS of cas: 6292-59-7.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Bai, Xiaodong, once mentioned the application of 6292-59-7, Name is 4-(tert-Butyl)benzenesulfonamide, molecular formula is C10H15NO2S, molecular weight is 213.3, MDL number is MFCD00068599, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/6292-59-7.html.

The partial structure and immunology of the lipopolysaccharide (LPS) of Pseudomonas stutzeri KMM 226, a bacterium isolated from a seawater sample collected at a depth of 2000 m, was characterised. The O-polysaccharide was built up of disaccharide repeating units constituted by l-Rhap and d-GlcpNAc: -> 2)-alpha-l-Rhap-(1 -> 3)-alpha-d-GlcpNAc-(1 ->. The structural analysis of the lipid A showed a mixture of different species. The major species were hexa-acylated and penta-acylated lipids A, bearing the 12:0(3-OH) in amide linkage and 10:0(3-OH) in ester linkage, while the secondary fatty acids were present only as 12:0. The presence of 12:0(2-OH) was not detected. The immunology experiments demonstrated that P. stutzeri KMM 226 LPS displayed a low ability to induce TNF-alpha, IL-1 beta, IL-6, IL-8 and IL-10 cytokine production and acted as an antagonist of hexa-acylated Escherichia coli LPS in human blood in vitro.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 6292-59-7, Name is 4-(tert-Butyl)benzenesulfonamide, molecular formula is C10H15NO2S. In an article, author is Liu, Panyu,once mentioned of 6292-59-7, HPLC of Formula: https://www.ambeed.com/products/6292-59-7.html.

Ovarian cancer is one of the most fatal female malignancies while targeting apoptosis is critical for improving ovarian cancer patients’ lives. Survivin is regarded as the most robust anti-apoptosis protein, and its overexpression in ovarian cancer is related to poor survival and apoptosis resistance. Piperlongumine (PL) extracted from peppers is defined as an active alkaloid/amide and exhibits a broad spectrum of antitumor effects. Here, we demonstrate that PL induces the rapid depletion of survivin protein levels via reactive oxygen species (ROS)-mediated proteasome-dependent pathway in vitro, while exerting a remarkable inhibitory influence on the proliferation of ovarian cancer cells. Overexpression of survivin raises the survival rate of ovarian cancer cells to PL. Moreover, PL inhibits ovarian cancer cells xenograft tumor growth and downregulates survivin in vivo. Our findings reveal a previously unrecognized mechanism of PL in suppressing survivin expression as well as survivin promotes piperlongumine resistance in ovarian cancer and suggest that ROS-mediated proteasome-dependent pathway can be exploited to overcome apoptosis resistance triggered by aberrant expression of survivin.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Related Products of 6292-59-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 6292-59-7, Name is 4-(tert-Butyl)benzenesulfonamide, SMILES is C1=CC(=CC=C1C(C)(C)C)[S](N)(=O)=O, belongs to amides-buliding-blocks compound. In a article, author is Wang, Jin, introduce new discover of the category.

A method for the synthesis of N-Cbz-protected phosphorylic analogs of proline by cyclic amidoalkylation of various hydrophosphorylic compounds was developed. Combination of amide and carbonyl fragments in the 4-N-Cbz-aminobutyraldehyde molecule allows to realize the three-center two-component amide version of the Kabachnik-Fields reaction.

Related Products of 6292-59-7, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6292-59-7.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics