Adding a certain compound to certain chemical reactions, such as: 626-88-0, name is 1-Bromo-4-methylpentane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-88-0, category: bromides-buliding-blocks
To a solution of Magnesium turning (46 mg, 1.9 mmol) with catalytic amount of iodine indiethylether (1 mL) was added 1-bromo-4-methyl pentane(0.345 mL, 2.37 mmol). The reaction mixture was stirred under argon gas until complete consumption of the Magnesium turning at ambient temperature. To a reaction mixture was added 9 (500 mg,1.58 mmol) in diethylether (1 mL) at ambient temperature. The reaction mixture was stirred until the bubbling was over at ambient temperature. The reaction mixture was quenched with 2 N HCl, and diluted with EtOAc. The organic phase was washed with H2O and brine, dried over MgSO4, and concentrated in vacuo. Purification of the residue via flash column chromatography on silica gel (EtOAc:n-Hexane 1:10 to 1:5) afforded 96 mg (15%) of the desired alcohol11: 1H NMR (CDCl3, 300 MHz) d 5.35 (d, J 5.3 Hz, 1H), 3.53 (m, 1H),2.32-2.24 (m, 2H), 2.11-0.86 (m, 42H). LR-MS (FAB) m/z 425(M Na)
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Reference:
Article; Kim, Kyeojin; Maharjan, Sony; Lim, Changjin; Kim, Nam-Jung; Agrawal, Vijayendra; Han, Young Taek; Lee, Sujin; An, Hongchan; Yun, Hwayoung; Choi, Hyun-Jung; Kwon, Young-Guen; Suh, Young-Ger; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 184 – 194;,
Bromide – Wikipedia,
bromide – Wiktionary