Category: 625-51-4

Adding a certain compound to certain chemical reactions, such as: 625-51-4, name is N-(Hydroxymethyl)acetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 625-51-4, Formula: C3H7NO2

To a solution of 200 mg (0.50 mmol) of (4R)-1-{[6-(4-fluorophenoxy)pyridin-3-yl)methyl}-4-mercaptopyrrolidin-2-one dihydrochloride obtained in Example 17 in 1 mL of trifluoroacetic acid, 49 mg (0.55 mmol) of acetamidemethanol was added, the reaction mixture was stirred at room temperature for 10 minutes, and then the solvent was distilled off under reduced pressure. To the residue thus obtained was added ethyl acetate, and the mixture was washed with saturated aqueous sodium hydrogen carbonate and then saturated brine, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by preparative TLC (chloroform:methanol = 10:1) to yield 154 mg (79%) of the title compound. Melting Point 94 – 95C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(Hydroxymethyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1500658; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

625-51-4, A common compound: 625-51-4, name is N-(Hydroxymethyl)acetamide, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

EXAMPLE 5 40.8 g (0.4 mol) of acetic anhydride were cooled to 10 C. After this, 16.4 g (0.2 mol) of phosphorous acid were introduced in the course of 5 minutes, with stirring and cooling. 17.8 g (0.2 mol) of N-hydroxymethylacetamide were subsequently added dropwise at 10 C. in the course of 10 minutes. After this, the mixture was first allowed to come to room temperature and then refluxed for 2.5 hours. The mixture was subsequently cooled. 10 ml of water were then added in portions. After this, the mixture was kept under reflux for 1 hour. After this, a mixture of 10 ml of acetic acid and 1.5 ml of water was added, and stirring was continued. After crystallisation and filtration with suction, 16.3 g (53% of theory) of acetylaminomethanephosphonic acid of a melting point of 188-194 C. were obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(Hydroxymethyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoechst Aktiengesellschaft; US5432291; (1995); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics