Related Products of 622-46-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 622-46-8, name is Phenyl carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of this phenyl carbamate (188 mg, 0.59 mmol) in toluene (3 ml) were added triethylamine (72 mg, 0.71 mmol) and 3-[4-(2-heptylaminoethyl)piperazin-1-yl]propanol (168 mg, 0.59 mmol) and the mixture was stirred at 80 C. for 3 hours. The reaction solution was diluted with water and extracted with chloroform. The organic layer was washed with water and a saturated sodium chloride solution successively, dried over anhydrous sodium sulfate and concentrated in vacuo. The resulting residue was purified by a silica gel column chromatography (silica gel 15 g, developing solvent; chloroform_methanol=40:1 10:1) to provide 249 mg (yield 83%) of N’-[2,4-bis(methylthio)-6-methyl-3-pyridyl]-N-heptyl-N-[2-[4-(3-hydroxypropyl)piperazin-1-yl]ethyl]urea as colorless oil. The same reaction and treatment as in Example 19 were conducted using this urea compound instead of N’-(2,6-diisopropylphenyl)-N-heptyl-N-[2-[4-(3-hydroxypropy 1)piperazin-1-yl]ethyl]urea, and the resulting compound was converted into its salt with hydrochloride in a conventional manner to provide the desired compound as colorless powdery crystals. Melting point: 208-210 C. IR (KBr) cm-1: 3421, 3258, 1658, 1562, 1494. 1H-NMR (d6-DMSO) delta: 0.87 (3H, t, J=6.8 Hz), 1.21-1.35 (8H, m), 1.50-1.66 (2H, m), 2.28 (2H, quint, J=6.6 Hz), 3.39 (6H, s), 2.45 (3H, s), 2.75-4.01 (18H, m), 6.88 (1H, s), 7.30-7.37 (2H, m), 7.63-7.68 (2H, m), 8.34 (1H, br s). Elementary analysis as: C32H48N6O2S3.2HCl Calculated: C, 53.54; H, 7.02; N, 11.71; S, 13.40; Cl, 9.88. Found: C, 53.35; H, 7.01; N, 11.63; S, 13.37; Cl, 9.88.
The synthetic route of Phenyl carbamate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kowa Company, Ltd.; US6969711; (2005); B2;,
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