Synthetic Route of 62005-48-5, These common heterocyclic compound, 62005-48-5, name is N-(2,2-Dimethoxyethyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 0086] To a solution of crude N-(2,2-dimethoxyethyl)ethanesulfonamide in acetone: water (1: 1, 4 niL) was added Amberlyst-15 Hydrogen form (1.0 g). The resulting mixture was stirred over two days at room temperature. The suspension was filtered through celite and concentrated under reduced pressure to afford crude N-(2-oxoethyl)ethanesulfonamide (614 mg) as a yellow oil. Used without further purification. 1H NMR (400 MHz, CDC13) delta 9.68 (s, J = 1.1 Hz, 1H), 4.15 (d, J = 5.2 Hz, 2H), 3.07 (q, J = 7.4 Hz, 2H), 1.40 (t, J = 7.4 Hz, 3H).
Statistics shows that N-(2,2-Dimethoxyethyl)acetamide is playing an increasingly important role. we look forward to future research findings about 62005-48-5.
Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; BRUCELLE, Francois; GEHLING, Victor, S.; KHANNA, Avinash; (74 pag.)WO2018/81343; (2018); A1;,
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