Category: 618-48-4

Adding a certain compound to certain chemical reactions, such as: 618-48-4, name is 3-Chlorobenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 618-48-4, SDS of cas: 618-48-4

General procedure: DDQ (20 mol%, 9.08 mg, 0.04 mmol) and BPO (20 mol%,9.69 mg, 0.04 mmol) were added to a mixture of 1,3-diarylpropene1 (0.24 mmol) and substrate 2 (0.2 mmol) in CH3NO2 (1 mL). Thereaction was carried out at 100 C under an oxygen atmosphere(oxygen balloon) for 24 h. The resulting mixture was purified by flashcolumn chromatography on silica gel (petroleum ether:ethyl acetate =10:1-20:1) to give the desired pure product 3a-k.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Cheng, Dongping; Zhou, Xiayi; Yuan, Kun; Yan, Jizhong; Journal of Chemical Research; vol. 40; 3; (2016); p. 127 – 129;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 618-48-4, name is 3-Chlorobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 618-48-4

Then slowly raise the temperature, turn on the ultrasonic generator at the same time, control the ultrasonic frequency of 20KHz, the concentrated ultrasonic horn is directly immersed in the reaction liquid of the kettle body, and a large amount of energy is directly transmitted to the reaction medium.Effectively convert electrical energy into ultrasonic energy, and control the size of ultrasonic energy by changing the amplitude of the generator. Use a constant temperature system to make the material react at a constant temperature of 230 ~ 250 C for 2h, and then continue to increase the temperature, control the temperature of 250 ~ 270 C, and react for 2h. To generate a mixture containing m-chlorobenzonitrile, turn off the ultrasonic generator.Crude nitrile was distilled off from the mixture containing m-chlorobenzonitrile under reduced pressure, and the residue after distillation contained intermediate products (ammonium m-chlorobenzoate and m-chlorobenzamide) produced by the reaction, which were left in the ultrasonic thermostat and continued at the next feeding reaction.The crude nitrile is washed with water, filtered, dried and then distilled under reduced pressure to obtain the finished product. The content of m-chlorobenzonitrile measured by high performance liquid chromatography was 97.0%. Calculate the yield. Based on m-chlorobenzoic acid, the yield of finished m-chlorobenzonitrile is 92.5%.The wastewater produced by washing the crude nitrile with water contains available raw materials m-chlorobenzoic acid, the intermediate products ammonium m-chlorobenzoate, and m-chlorobenzamide. The water is recovered by distillation and concentration, and the intermediate products are recovered. After drying, During the secondary reaction, it was put into the reaction kettle as part of the raw materials to continue the reaction.

The synthetic route of 3-Chlorobenzamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanmenxia Huanyu Biochemical Technology Co., Ltd.; Duan Jingjie; Zhang Weimin; Liang Zhenxian; Wei Zhanyong; Tan Jing; Zhang Kun; Wang Xinyue; Wang Yan; Wang Zhiquan; (7 pag.)CN110467541; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics