Category: 614-76-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 614-76-6, name is 2-BroMoacetanilide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 614-76-6

2-Bromoacetanilide (1 .68 g, 90% content, 7.06 mmol) is dissolved in dry THF (15 mL) and cooled to -78 C under a nitrogen atmosphere. n-Butyllithium (2.5 M solution in hexane, 5.93 mL, 14.8 mmol) is added dropwise and the mixture stirred at -78 C for 30 minutes. tert-Butyl 2-formylpropan-2-ylcarbamate (1 .39 g, 7.42 mmol) in dry THF (10 mL) is added dropwise and the mixture stirred for 30 minutes at -78 C then allowed to warm to -50 C over 1 hour. Saturated aqueous ammonium chloride solution (20 mL) is added, the mixture allowed to warm to room temperature and the phases separated. The organic phase is washed with brine, dried and the solvent removed. The residue is purified by flash chromatography (Eluent 0-2% MeOH in DCM) to give the title product (370 mg, 16%). UPLC-MS (Method 1 ): Rt = 1 .02 min MS (ESI+): m/z = 323 (M+H)+

According to the analysis of related databases, 614-76-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MAZZAFERRO, Rocco; FERRARA, Marco; GIOVANNINI, Riccardo; LINGARD, Iain; (195 pag.)WO2016/75239; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 614-76-6, These common heterocyclic compound, 614-76-6, name is 2-BroMoacetanilide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of aa (2.0 g, 9.34 mmol), tributylvinyl stannane (3.55 mL, 12.15 mmol) and Pd(PPh3)2Cl2 (1.64 g, 2.335 mmol) in toluene was heated at 95 C. under nitrogen after degassing. After 1 hour, the reaction mixture was concentrated and purified by flash chromatography (SiO2, 100% CH2Cl2 to 50% EtOAc/CH2CL2) followed by recrystalization from EtOH/H2O to give bb (732 mg, 49%). HPLC Rt=1.45 min.

Statistics shows that 2-BroMoacetanilide is playing an increasingly important role. we look forward to future research findings about 614-76-6.

Reference:
Patent; Gavai, Ashvinikumar V.; Norris, Derek J.; Han, Wen-Ching; Vite, Gregory D.; Fink, Brian E.; Tokarski, John S.; US2005/192310; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics