Category: 61189-99-9

Transamidation of primary amides with amines catalyzed by zirconocene dichloride was written by Atkinson, Benjamin N.;Chhatwal, A. Rosie;Lomax, Helen V.;Walton, James W.;Williams, Jonathan M. J.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2012.Application of 61189-99-9 This article mentions the following:

Zirconocene dichloride has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80° in 5-24 h. For favorable substrates, the reaction can be performed at temperatures as low as 30°. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Application of 61189-99-9).

2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application of 61189-99-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Total synthesis of antibiotic althiomycin was written by Inami, Kaoru;Shiba, Tetsuo. And the article was included in Bulletin of the Chemical Society of Japan in 1985.Quality Control of 2,2-Diethoxyacetamide This article mentions the following:

Total synthesis of antibiotic althiomycin (I) was achieved staring from D-cysteine. The imide bond between thiazoline and the pyrrolinone part was constructed by coupling reaction of sodium salt of pyrrolinone with cysteine active ester or by photoreaction with diketene. The hydroxymethyl group attached on the carbon adjacent to C-2 of the thiazoline ring, was introduced by aldol condensation posterior to the thiazoline ring formation. The thiazole part was introduced in a final step in whole process of the total synthesis of the antibiotic. The synthetic althiomycin was identical with the natural antibiotic in all respects. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Quality Control of 2,2-Diethoxyacetamide).

2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of 2,2-Diethoxyacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mechanochemical Synthesis of Primary Amides was written by Gomez-Carpintero, Jorge;Sanchez, J. Domingo;Gonzalez, J. Francisco;Menendez, J. Carlos. And the article was included in Journal of Organic Chemistry in 2021.Electric Literature of C6H13NO3 This article mentions the following:

Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters RCOOEt (R = 3-fluorophenyl, 1,3-diethoxy-1,3-dioxopropan-2-yl, thiophen-2-yl, etc.) and 2-chromanone with ethanol and calcium nitride afforded the corresponding primary amides RC(O)NH₂in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodol. was applied to α-amino esters (S)-H₂NCH(CH₂R¹)C(O)OEt [R¹ = Ph, (methylsulfanyl)methyl] and N-Boc dipeptide esters (S)-(CH₃)₃COC(O)NHCH(CH₂R²)C(O)NHCH₂C(O)OEt (R² = H, Ph, 1H-indol-3-yl) and also to the synthesis of rufinamide, an antiepileptic drug. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Electric Literature of C6H13NO3).

2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C6H13NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics