Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60041-89-6, name is 2-Amino-5-fluoro-N-phenylbenzamide, This compound has unique chemical properties. The synthetic route is as follows., Formula: C13H11FN2O
[415] To a 0 °C stirred mixture of 2-amino-5-fluoro-N-phenylbenzamide (1.0 g, 4.35 mmol) and (2iS)-2-(teri-butoxycarbonylamino)propanoic acid (987 mg, 5.22 mmol) in DCM (8 mL) were added DIPEA (1.5 mL, 8.6 mmol) and HATU (1.99 g, 5.23 mmol), the mixture was stirred at 45 °C overnight. Water (30 mL) was added to the above mixture, and the resulting mixture was extracted with EtOAc (50 mL chi 2). The combined organic phases were concentrated in vacuo, and the residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 5/1) to give the title compound as an off-white solid (1.6 g, 92.0percent). MS (ESI, neg. ion) m/z: 400.2 [M-H]”; NMR (400 MHz, DMSO-<) delta (ppm): 1 1.08 (s, 1H), 10.49 (s, 1H), 8.47 (dd, J = 9.1, 5.3 Hz, 1H), 7.73 (d, J= 7.7 Hz, 3H), 7.52 (d, J = 6.5 Hz, 1H), 7.44 (td, J = 8.8, 3.0 Hz, 1H), 7.36 (t, J = 7.9 Hz, 2H), 7.15 (t, J = 7.4 Hz, 1H), 4.08-3.93 (m, 1H), 1.30 (s, 9 H), 1.28-1.27 (d, J=4.0 Hz, 3 H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 60041-89-6.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; WANG, Tingjin; FENG, Xuejin; WU, Shuang; ZHANG, Tao; WANG, Liang; (139 pag.)WO2016/149160; (2016); A1;,
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