In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-70-0, name is 2,4-Dimethylbromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H9Br
General procedure: By using 3,6-di-tert-butyldimethylsilyloxy-Si-xanthone obtained in Example 1, the step (6), Compounds (a) to (e) were synthesized by the following procedures. (0134) A bromobenzene derivative (1.0 mmol) and anhydrous tetrahydrofuran (THF, 5 mL) were added to a sufficiently dried flask under an argon atmosphere. The mixture was cooled to -78 C., and then 1 M sec-butyllithium (0.5 mmol) was added thereto, and the mixture was stirred for 20 minutes. 3,6-Di-tert-butyldimethylsilyloxy-Si-xanthone (0.015 to 0.019 mmol) dissolved in anhydrous THF (5 mL) was slowly added to the mixture at the same temperature, and the mixture was brought to room temperature. The mixture was stirred at room temperature for 1 hour, and then 2 N hydrochloric acid (5 mL) was added thereto, and the mixture was stirred for 20 minutes. The reaction mixture was extracted with dichloromethane, and the organic layer was washed with brine, and dried over anhydrous sodium sulfate. The solvent was removed, and then the residue was purified by HPLC to obtain the objective substance.
The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNIVERSITY OF TOKYO; Nagano, Tetsuo; Hanaoka, Kenjiro; Koide, Yuichiro; Egawa, Takahiro; US9170266; (2015); B2;,
Bromide – Wikipedia,
bromide – Wiktionary