Category: 57957-24-1

Adding a certain compound to certain chemical reactions, such as: 57957-24-1, name is N-(1-Phenylvinyl)acetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57957-24-1, Safety of N-(1-Phenylvinyl)acetamide

General procedure: A reaction tube was charged with N-acetylenamide 1a (100 mg, 0.636 mmol), alkyne 2a (124 mg, 0.699 mmol), Cu(OAc)2.H2O (126 mg, 0.636 mmol), KPF6 (23.4 mg, 0.127 mmol) and [RuCl2(p-cymene)]2 (7.8 mg, 0.0127 mmol). To that, DME or water (3 mL) was added by syringe. The reaction mixture was stirred at 110 C under N2 as indicated time in the table 1.The reaction mixture was cooled down to rt, diluted with 10 mL of DCM. The mixture was then filtered through Celite. The combined organic portion was washed with water, then dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel with hexane/ethyl acetate as eluent to yielded the desired pyrrole 3a (202 mg, 0.605 mmol) in 95% yield. Products obtained in this work were characterized by spectral methods particularly with 1H, 13C NMR, and ESI-Mass analyses, further, the data were compared with those reported.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(1-Phenylvinyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Murugan, Kaliyappan; Liu, Shiuh-Tzung; Tetrahedron Letters; vol. 54; 21; (2013); p. 2608 – 2611;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 57957-24-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57957-24-1 as follows.

The compound 1a prepared in Example 2 was a boronized substrate, a different chiral ligand prepared in situ and Rh (nbd)2BF4As a catalyst, under different conditions, the preparation of chiral alpha-amino tertiary borate.The reaction is carried out by reacting alpha-arylalkenamide (1a) (0.3 mmol, 1.0 equiv), [Rh (nbd)2] BF4(0.006 mmol, 2 mol%), chiral ligands (0.006 mmol, 2 mol%), boronic acid pinacol ester (0.45 mmol, 1.5 equiv) and base (0.06 mmol, 0.2 equiv) were added to the dry reaction tube.Add solvent (1 mL).Followed by reaction at 60 C for 12 hours.The reaction was quenched with water (3 mL) and extracted with ethyl acetate (10 mL x 3).The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography.The ee value of the reaction was determined by HPLC (OD-H or AD-H).

According to the analysis of related databases, 57957-24-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Tang Wenjun; Zhao Guoqing; Hu Naifu; (31 pag.)CN106146543; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 57957-24-1,Some common heterocyclic compound, 57957-24-1, name is N-(1-Phenylvinyl)acetamide, molecular formula is C10H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 12. Asymmetric hydrogenation of different unsaturated hydrocarbon compounds with chiral ligand 6 and [Rh(nbd)2]BF4 at room temperature.The following compounds were hydrogenated in presence of a catalyst of the invention (ligand 6 and [Rh(nbd)2]BF4) at room temperature.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-(1-Phenylvinyl)acetamide, its application will become more common.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 57957-24-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57957-24-1, name is N-(1-Phenylvinyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

; (Examples 10 to 22); In a 50-mL autoclave, 6 mg (1.0¡Á10-2 mmol) of the [rhodium(I)((1S,1S’,2R,2R’)-1,1′-do-tert-butyl-[2,2′]-diphosphetane)(norbornadiene)]hexafluorophosphate synthesized in Example 8 and used as a catalyst and 1 mmol of the dehydroamino acid derivative (or enamide derivative) shown in Table 1 were charged. Then, the system was evacuated and purged with hydrogen four times. The autoclave was returned to normal pressure, and a cock was opened to rapidly add 4 mL of degassed dehydrated methanol from the cock using a syringe and then closed. The reactor was cooled with dry ice/ethanol, and then the reaction system was again evacuated and purged with hydrogen four times. After the hydrogen pressure was set to a predetermined value, the refrigerant was removed, and the reaction system was stirred with a magnetic stirrer until hydrogen consumption was stopped. After the completion of reaction, the reaction solution was passed through silica gel column chromatography (developing solvent: ethyl acetate) to remove the catalyst, and then the residue was concentrated with an evaporator to obtain a reduced product. In any reaction, the yield was about 100%. The optical purity (ee) of each product was analyzed with chiral HPLC or chiral GC. The results are shown in Table 1. These results were obtained at a ratio of substrate : catalyst = 100 : 1. [Table 1]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(1-Phenylvinyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics