Synthetic Route of 5577-13-9, A common heterocyclic compound, 5577-13-9, name is Ethyl tosylcarbamate, molecular formula is C10H13NO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of ethyl (phenylsulfonyl) carbamate (1.2 mmol, 18a-d) in toluene (5 mL) was addeddropwise to a solution of 8a-d or 14a-d (1 mmol) in toluene (15 mL). Upon completion of the addition,the reaction mixture was stirred at 120 C for 6 h and monitored by thin-layer chromatography (TLC).The reaction mixture was cooled to room temperature and concentrated under a reduced pressure.Then, ethyl acetate was added and the insoluble materials were collected by filtration and driedto yield the target compounds 19a-d, 20a-d, 21a-d, 22a-d and 23a-d, which were recrystallizedfrom isopropanol.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhao, Bingbing; Lei, Fei; Wang, Caolin; Zhang, Binliang; Yang, Zunhua; Li, Wei; Zhu, Wufu; Xu, Shan; Molecules; vol. 23; 7; (2018);,
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