Category: 5455-98-1

On January 22, 2015, Bottegoni, Giovanni; De Simone, Alessio; Ruda, Gian Filippo; Cavalli, Andrea; Bandiera, Tiziano; Piomelli, Daniele published a patent.Product Details of 5455-98-1 The title of the patent was Preparation of phenyl carbamates as inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR). And the patent contained the following:

Disclosed are compounds I [Ar = aromatic or heteroaromatic single or fused ring comprising heteroatoms selected from N, O and S; R1, R2 = independently H, halo, alkyl, etc.; X = N or CH; Y = -CH2(CH2)nCH2- or -CH2CH:CHCH2- (wherein Y is optionally substituted by B) ; n = 0-3; B = F, OH, CH2OH, etc.; R3 = aromatic or heteroaromatic ring, benzyl, benzoyl (optionally substituted by R5), etc.; R5 = OH, NH2, CN, etc.; R4 = H, halo, alkyl, etc.; or R3 and R4, together with the Ph ring to which they are connected, may form 9H-carbazole ring; or pharmaceutically acceptable salts thereof]. For example, compound II was prepared by following general procedure: to a solution of Boc2O (1.4 equiv) in acetonitrile were added DMAP (1 equiv)/acetonitrile and an amine (1 equiv)/acetonitrile, the resulting mixture was stirred at room temperature for 10 min, treated with an alc. derivative (1.2-1.4 equiv) at room temperature for 22 h, concentrated in vacuo, dissolved in Et acetate, washed with saturated aqueous NaHCO3, dried over Na2SO4, concentrated, and purified. The exemplified compound II exhibited IC50 of 4.4 nM for human FAAH and EC50 of 14.0 nM for D3DR. Compounds I are claimed useful for the treatment of nicotine use disorders, substance abuse addiction, eating diorders, etc. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Product Details of 5455-98-1

The Article related to fatty acid amide hydrolase faah inhibitor phenyl carbamate preparation, d3 dopamine receptor d3dr modulator phenyl carbamate preparation, nicotine eating disorder substance abuse addiction treatment phenyl carbamate and other aspects.Product Details of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 15, 2015, Mueller, Thomas Ernst; Guertler, Christoph; Basu, Susmit; Leitner, Walter published a patent.Application of 5455-98-1 The title of the patent was Method for the production of oxazolidinone compounds. And the patent contained the following:

The present invention relates to a method for the production of oxazolidinone compounds, comprising the step of slowly reacting an isocyanate compound with an epoxide compound in the presence of a Lewis acid catalyst. The invention further relates to an oxazolidinone compound, obtainable by a method according to the invention, with a color as determined according to ASTM D1209-05 (2011) of ≤200 and a molar ratio of the oxazolidinone compound to isocyanurate byproduct o/i of ≥85/15. Lastly, the invention relates to an oligomeric or polymeric oxazolidinone compound, obtainable by a method according to the invention using an isocyanate compound with two or more NCO groups per mol. and an epoxide compound with two or more epoxy groups per mol., comprising at least two units derived from the isocyanate compound and at least two units derived from the epoxide compound, with a color as determined according to ASTM D1209-05 (2011) of ≤200. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to oxazolidinone derivative manufacture epoxide isocyanate reaction lewis acid catalyst, diepoxide diisocyanate copolymer manufacture lewis acid catalyst, discoloration prevention oxazolidinone derivative manufacture lewis acid reaction catalyst and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 22, 2014, Mueller, Thomas Ernst; Guertler, Christoph; Basu, Susmit; Leitner, Walter published a patent.Formula: C11H9NO3 The title of the patent was Production of low and high molecular weight oxazolidinone compounds. And the patent contained the following:

The invention relates to a method for the production of oxazolidinone compounds, comprising the step of slowly reacting an isocyanate compound with an epoxide compound in the presence of a Lewis acid catalyst. The invention further relates to an oxazolidinone compound, obtainable by a method according to the invention, with a color as determined according to ASTM D1209 – 05 (2011) of ≤200 and a molar ratio of the oxazolidinone compound to isocyanurate byproduct o/i of ≥85/15. Lastly, the invention relates to an oligomeric or polymeric oxazolidinone compound, obtainable by a method according to the invention using an isocyanate compound with two or more NCO groups per mol. and an epoxide compound with two or more epoxy groups per mol., comprising at least two units derived from the isocyanate compound and at least two units derived from the epoxide compound, with a color as determined according to ASTM D1209 – 05 (2011) of ≤200. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to oxazolidinone derivative manufacture epoxide isocyanate reaction lewis acid catalyst, diepoxide diisocyanate copolymer manufacture lewis acid catalyst, discoloration prevention oxazolidinone derivative manufacture lewis acid reaction catalyst and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2020, Parasram, Marvin; Shields, Benjamin J.; Ahmad, Omar; Knauber, Thomas; Doyle, Abigail G. published an article.Recommanded Product: 5455-98-1 The title of the article was Regioselective Cross-Electrophile Coupling of Epoxides and (Hetero)aryl Iodides via Ni/Ti/Photoredox Catalysis. And the article contained the following:

A cross-electrophile coupling reaction of epoxides and (hetero)aryl iodides that operates via the merger of three catalytic cycles involving a Ni-, Ti-, and organic photoredox catalyst has been developed. Three distinct classes of epoxides, styrene oxides, cyclic epoxides, and terminal aliphatic epoxides, underwent coupling in moderate to good yield and high regioselectivity with the use of three different nitrogen-based ligands for Ni under otherwise identical reaction conditions. The mild reaction conditions accommodate a broad scope of abundant and complex coupling partners. Mechanistic studies suggest that when styrene oxides are employed radical intermediates are involved via Ti-radical ring opening of the epoxide. Conversely, for terminal aliphatic epoxides, involvement of an iodohydrin intermediate enables the formation of the unexpected linear product. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 5455-98-1

The Article related to arylalkyl alc regioselective preparation, epoxide hetero aryl iodide cross electrophile coupling photoredox catalyst, arylation, cross-electrophile coupling, epoxides, nickel catalysis, photochemistry, photoredox catalysis, radical chemistry, titanium catalysis and other aspects.Recommanded Product: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2020, Ebrahimi, Amirhossein; Rezazadeh, Mostafa; Khosravi, Hormoz; Rostami, Ali; Al-Harrasi, Ahmed published an article.Application of 5455-98-1 The title of the article was An Aminopyridinium Ionic Liquid: A Simple and Effective Bifunctional Organocatalyst for Carbonate Synthesis from Carbon Dioxide and Epoxides. And the article contained the following:

An aminopyridinium ionic liquid was presented as a green, tunable, and active metal-free one-component catalytic system for the atom-efficient transformation of oxiranes and CO2 to cyclic carbonates. Inclusion of a pos. charged moiety into aminopyridines, through a simple single-step synthesis, provided a one-component ionic liquid catalytic system with superior activity; effective in ring opening of epoxide, CO2 inclusion, and stabilization of oxoanionic intermediates. An efficiency assessment of a variety of pos. charged aminopyridines was pursued, and the impact of temperature, catalyst loading, and the kind of nucleophile on the catalytic performance was also investigated. Under solvent-free conditions, this bifunctional organocatalytic system was used for the preparation of 18 examples of cyclic carbonates from a broad range of alkyl- and aryl-substituted oxiranes and CO2, where up to 98% yield and high selectivity were achieved. DFT calculations validated a mechanism in which nucleophilic ring-opening and CO2 inclusion occur simultaneously towards cyclic carbonate formation. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to aminopyridinium ionic liquid organocatalyst preparation green chem, oxirane carbon dioxide aminopyridinium iodide organocatalyst cycloaddition reaction mechanism, dioxolanone preparation, carbon dioxide, hydrogen-bond donors, ionic liquids, organocatalysis, ring-opening reactions and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2016, Toda, Yasunori; Komiyama, Yutaka; Kikuchi, Ayaka; Suga, Hiroyuki published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Tetraarylphosphonium Salt-Catalyzed Carbon Dioxide Fixation at Atmospheric Pressure for the Synthesis of Cyclic Carbonates. And the article contained the following:

Phosphonium salts exhibit great utility in organic synthesis. However, tetraarylphosphonium salts (TAPS) have found limited use as catalysts. We demonstrate the TAPS-catalyzed carbon dioxide fixation at atm. pressure for the coupling reaction with epoxides. Five-membered cyclic carbonates were obtained, including enantio-enriched carbonates. Mechanistic studies revealed the origin of the behavior of TAPS to be the in situ formation of an active species by TAPS addition to epoxides via halohydrin intermediates. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to cyclic carbonate preparation carbon dioxide fixation epoxide atm pressure, tetraarylphosphonium salt preparation catalyst carbon fixation, crystal mol structure hydroxy methylphenyl triphenylphosphonium bromide, carbon dioxide fixation tetraarylphosphonium salt catalyzed epoxide atm pressure and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parzuchowski, Pawel G.; Swiderska, Aleksandra; Roguszewska, Marlena; Rolinska, Karolina; Wolosz, Dominik; Maminski, Mariusz published an article in 2020, the title of the article was Hyperbranched poly(ether-siloxane)s containing ammonium groups: Synthesis, characterization and catalytic activity.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

In this article we report an easy synthetic route towards hyperbranched polyglycerols (Amm-HBPGs) containing trimethylammonium groups and siloxane or hydroxyl end-groups. Siloxane derivatives of Amm-HBPGs were synthesized in an efficient five-step procedure including an anionic ring opening copolymerization of the phthalimide-epoxy monomer with glycidol, followed by reactions with allyl bromide, hydrosilylation with hydrogenheptamethyltrisiloxane, hydrazinolysis of phthalimide groups and quaternization of resulting amine groups with Me iodide. Hydroxyl derivatives were obtained by quaternization of previously reported aminated HBPG’s with Me iodide. Polymeric products were characterized using various NMR techniques, FTIR, and elemental anal. Both Amm-HBPGs were shown to be effective in catalysis of addition of CO2 to oxirane. The hydrophilic catalysts showed higher efficiency but synthesis of ethylene carbonate was accompanied by formation of small amounts of ethylene glycol. The siloxane-containing catalyst was easily separable from reaction mixture showing high potential in the process of converting carbon dioxide into valuable chem. raw materials. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to trimethylammonium polyether siloxane hyperbranched polymer anionic ring opening copolymerization, carbon dioxide oxirane ethylene carbonate cycloaddition catalyst, carbon dioxide, catalysis, cycloaddition, ethylene carbonate, hyperbranched polymer, oxirane, polyglycidol, polysiloxane and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 24, 2016, Shia, Kak-Shan; Jan, Jiing-Jyh; Tsou, Lun Kelvin; Chen, Chiung-Tong; Chao, Yu-Sheng published a patent.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of quinazoline heterocyclic compounds and use thereof to mobilize hematopoietic stem cells and endothelial progenitor cells. And the patent contained the following:

Heterocyclic compounds I [wherein: M = (CH2)m; each of R1 and R2, independently, is H, halogen, NO2, CN, NH2, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; or, R1 and R2, together with the two carbon atoms to which they are bonded, are C5-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl, each of alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [Each of R3 and R4, independently, is NRbRc, Z1 or Z2; in which: each of Rb and Rc, independently, is H or C1-6-alkyl;R5 is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, arylalkyl, heteroaryl alkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, aryl, and heteroaryl being optionally substituted;]. [R6 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl;L1 is heteroaryl, C1-10-heterocycloalkyl, NH, or NRd; in which Rd is C(:O)(CH2)2CHNH2CO2Re; Re being H, C1-6-alkyl, C3-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl;R7 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, alkoxyl, cycloalkyl,heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [M is 1 – 6; n is 1 – 6; each of R8 and R9, independently, is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted; L2 is C1-6-alkyl; or L2, together with R8 8or R9 and the nitrogen atom to which they are bonded, is C4-10-heterocycloalkyl or heteroaryl; and,]. [R10 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, ester, amide thioamide, or acyl; each of alkyl, alkoxyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl alkyl, and heteroaryl alkyl being optionally substituted] are shown herein. Thus, quinazoline II was prepared from 2,4-dichloroquinazoline via amination with tert-Bu 4-aminopiperidine-1-carboxylate; amination with aminotriazle III; and debutoxycarbonylation. The synthesis of II is also desribed. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to heterocyclic compound preparation pharmaceutical composition mobilizer hematopoietic stem cells, tissue injury treatment quinazoline pyrimidine compound, cancer treatment quinazoline pyrimidine compound, inflammatory disease treatment quinazoline pyrimidine compound, autoimmune disease treatment quinazoline pyrimidine compound and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics