Category: 5455-98-1

On December 1, 2016, Gampe, Christian M.; Kahne, Daniel Evan; Kahne, Suzanne Walker; Qiao, Yuan; East, Stephen; Parkes, Alastair L.; Southey, Michelle; Hunter, James; Whittaker, Mark; Arthuis, Martin published a patent.Application of 5455-98-1 The title of the patent was Preparation of 6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one derivatives as inhibitors of bacterial glycosyl transferases. And the patent contained the following:

The title compounds of formula I [A = independently each (un)substituted C2-6 alkyl, aryl, carbocyclyl, 5-membered heteroaryl, or 6-membered heteroaryl; B = independently H or each (un)substituted alkyl, alkenyl, alkynyl, aryl, carbocyclyl, heterocyclyl, or heteroaryl; Y = a bond or each (un)substituted C1-6-alkylene, C3-6 carbocyclylene, or heterocyclylene; X = a bond, O, CH2, NRNX, NRNX-C(O)-NRNX, or (un)substituted heterocyclylene; L = a bond, O, C(O), NRLBC(O), C(O)NRLB, NRLB, or SO2; each RLB = independently H or each (un)substituted alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or RLB and B are taken together with their intervening atoms to form an (un)substituted heterocyclic ring; R1 = H, halogen, or (un)substituted substituted C1-6 alkyl; RN1 = H, (un)substituted C1-6 alkyl, or a nitrogen protecting group; RNX = H, (un)substituted C1-6 alkyl, or a nitrogen protecting group], pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof are prepared The invention also provides pharmaceutical compositions of the compounds I for human and veterinary use. The compounds I are useful for inhibiting bacterial growth and therefore are useful in treating and/or preventing bacterial infections. Thus, 100 mg 2-(4-tert-butylphenyl)-4-(methylsulfanyl)-6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one and 190 mg N-(3-aminopropyl)-4-chloro-3-methylaniline were dissolved in 4 mL 1,4-dioxane, heated to 130° in a microwave for 11 h, then concentrated, and purified using HPLC to give 7.9 mg 2-(4-tert-butylphenyl)-4-[[3-[(4-chloro-3-methylphenyl)amino]propyl]amino]-6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one (II) (5% yield). II showed min. inhibitory concentration of 3.1, 2, and 4 μg/mL against methicillin-susceptible Staphylococcus aureus Newman, S. aureus 29213, and S. aureus 43300 at 24 h, resp. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to bacterial infection prevention treatment pyrazolotriazinone preparation, pyrazolotriazinone preparation inhibitor bacterial glycosyl transferase antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 18, 2016, Mueller, Thomas Ernst; Guertler, Christoph; Basu, Susmit; Rangheard, Claudine; Rivillo, David; Leitner, Walter; Koehler, Burkhard published a patent.Synthetic Route of 5455-98-1 The title of the patent was Manufacturing of polyoxazolidinone compounds with high stability by reacting a biscarbamate compounds with a bisepoxide compounds. And the patent contained the following:

The present invention relates to polyoxazolidinone compounds, a method for the production of polyoxazolidinone compounds, comprises the step of reacting a biscarbamate compound with a bisepoxide compound in the presence of a mono-carbamate, a mono-isocyanate and/or a mono-epoxide compound as chain regulator and a suitable base having a pKb value of ≤ 9 as catalyst. The invention further relates to the use of polyoxazolidinone compounds with high thermal stability. Thus, a mixture of O,O’-Dimethyl-4,4′-methylendiphenyl-1,1′-dicarbamate 6.33 g, 4,4′-isopropylidenediphenol diglycidyl ether 3.45 g, 4-tert-butylphenyl glycidyl ether 5.20 g and DBU 16.5 mg was admixed and heated 180° to get polyoxazolidinone with Tg 127 and thermal stability until 389°. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to polyoxazolidinone bisepoxide isocyanate thermal stability, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 8, 2018, there was a patent about biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Method for production of polyoxazolidinone, and spun fiber comprising polyoxazolidinone. And the patent contained the following:

A method for production of polyoxazolidinone compounds comprises reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) has a pKb value of ≤ 9. The invention also relates to a polyoxazolidinone compound produced according to the method, and a spun fiber comprising the polyoxazolidinone compound Thus, di-Me diphenylmethane-4,4′-dicarbamate (5.62 g, 17.9 mmol) and resorcinol diglycidyl ether (in resin form, Denacol EX 201, 3.65 g, 16.4 mmol) in o-dichlorobenzene (20 mL) were heated to 180° while stirring at 400 rpm, followed by addition of tert-butyliminotri(pyrrolidino)phosphorane (55 μL, 1% mol relative to biscarbamate) and tetraphenylstibonium bromide (0.18 g, 2% mol relative to biscarbamate), stirring for 480 min, adding 4-tert-butylphenyl glycidyl ether (1.5 mL, 6 mmol), o-dichlorobenzene (10 mL) and N-methyl-2-pyrrolidinone (5 mL), and stirring for another 60 min to obtain a polyoxazolidinone (chemoselectivity to oxazolidinone > 98%, 5-oxazolidinone regioisomer content of 50%, and 4-oxazolidinone content of 50%.). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 9, 2018, Mueller, Thomas Ernst; Guertler, Christoph; Koopmans, Carsten; Marker, Volker; Rangheard, Claudine; Leitner, Walter published a patent.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Method for production of polyoxazolidinone, and spun fiber comprising polyoxazolidinone. And the patent contained the following:

A method for production of polyoxazolidinone compounds comprises reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) has a pKb value of ≤ 9. The invention also relates to a polyoxazolidinone compound produced according to the method, and a spun fiber comprising the polyoxazolidinone compound Thus, di-Me diphenylmethane-4,4′-dicarbamate (5.62 g, 17.9 mmol) and resorcinol diglycidyl ether (in resin form, Denacol EX 201, 3.65 g, 16.4 mmol) in o-dichlorobenzene (20 mL) were heated to 180° while stirring at 400 rpm, followed by addition of tert-butyliminotri(pyrrolidino)phosphorane (55 μL, 1% mol relative to biscarbamate) and tetraphenylstibonium bromide (0.18 g, 2% mol relative to biscarbamate), stirring for 480 min, adding 4-tert-butylphenyl glycidyl ether (1.5 mL, 6 mmol), o-dichlorobenzene (10 mL) and N-methyl-2-pyrrolidinone (5 mL), and stirring for another 60 min to obtain a polyoxazolidinone (chemoselectivity to oxazolidinone > 98%, 5-oxazolidinone regioisomer content of 50%, and 4-oxazolidinone content of 50%.). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2013, Ali, Mohammad; Zarchi, Karimi; Tarabsaz, Ali published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was A versatile and regioselective synthesis of vicinal azidoalcohols using cross-linked poly(4-vinylpyridine) supported azide ion under solvent-free conditions. And the article contained the following:

A new polymeric reagent, cross-linked poly(4-vinylpyridine) supported azide ion, [P4-VP]N3, was introduced as polymeric reagents for efficient and regioselective conversion of epoxides to azidohydrins in the presence of crosslinked poly(4-vinylpyridine) supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The advantages of this polymeric reagent over some of those reported in the literature are easy work-up procedure and regeneration of the reagent. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to versatile regioselective synthesis vicinal azidoalc crosslinked polyvinylpyridine, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mamat, Marhaba; Liu, Changhong; Abdukerem, Dilshat; Abdukader, Ablimit published an article in 2021, the title of the article was A visible-light-induced thiol addition/aerobic oxidation cascade reaction of epoxides and thiols for the synthesis of β-hydroxylsulfoxides.COA of Formula: C11H9NO3 And the article contains the following content:

A photochem. thiol addition/aerobic oxidation cascade reaction had been developed. This protocol enabled efficient oxidative coupling of epoxides and thiols to access structurally valuable β-hydroxylsulfoxides RSO2CH2C(R1R2)OH [R = 4-MeC6H4, 4-ClC6H4, 4-MeOC6H4, etc.; R1 = H, Me; R2 = Me, Et, CO2Et, etc.]. A broad range of functional groups were compatible to obtain moderate to good yields of the target products. Mechanistic studies revealed a sequential reaction pathway involving base-promoted thiol addition of thiols to epoxides and visible-light-induced aerobic oxygenation of thioethers. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).COA of Formula: C11H9NO3

The Article related to beta hydroxylsulfoxide preparation, epoxide thiol cascade addition aerobic oxidation rose bengal catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.COA of Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 15, 2019, Wu, Chenggui; Yang, Xinjun; Shang, Yong; Cheng, Hong-Gang; Yan, Wei; Zhou, Qianghui published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy. And the article contained the following:

Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and an oxa-cyclization. This is a mild, scalable, chemoselective, and atom-economical protocol, compatible with various functionalized aryl iodides, epoxides, and terminal alkynes. With the ability to build up the mol. complexity rapidly and efficiently from feedstock chems., this method will have wide applications in organic synthesis. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to benzofused dioxabicycle preparation chemoselective regioselective, aryl iodide epoxide terminal alkyne catellani reaction oxacyclization, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2021, Alvarez-Miguel, Lucia; Burgoa, Jesus Damian; Mosquera, Marta E. G.; Hamilton, Alex; Whiteoak, Christopher J. published an article.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Catalytic Formation of Cyclic Carbonates using Gallium Aminotrisphenolate Compounds and Comparison to their Aluminium Congeners: A Combined Experimental and Computational Study. And the article contained the following:

The use of gallium aminotrisphenolate compounds as catalysts for the synthesis of cyclic carbonates from epoxides and CO2 was reported. The results showed that they were highly active and more so than the corresponding aluminum congeners. The catalyst system was applicable at low and elevated temperatures across a wide substrate scope including terminal, internal, multiple and fully deuterated epoxides. Applying low catalyst loadings allowed for a TON of 344,000 to be obtained, highlighting their stability. A DFT investigation confirmed that the gallium catalysts have lower energetic profiles compared to the aluminum congeners. Measurement of the Lewis acidity of both the gallium and aluminum aminotrisphenolate compounds using the Gutmann-Beckett method provided the exptl. proof that the gallium compounds were more Lewis acidic than their aluminum congeners. Finally, Ab-Initio Mol. Dynamic (AIMD) simulations investigated and quantified the dynamic behavior of the catalytic systems, highlighting an important increase in fluxionality in some cases which helps to explain the increase in catalytic activity. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to gallium aminotrisphenolate catalyst preparation lewis acidity, epoxide carbon dioxide gallium catalyst, cyclic carbonate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2012, Reddy, Pingili Krishna; Mukkanti, K.; Rao, Dodda Mohan published an article.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis of antibiotic linezolid analogues. And the article contained the following:

New oxazolidinones were synthesized and were evaluated for antibacterial activity against S. aureus, S. citreus, P. vulgaris, S. typhimurium, and K. pneumoniae. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to oxazolidinone antibiotic linezolid analog preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fiorio, Jhonatan L.; Rossi, Liane M. published an article in 2021, the title of the article was Clean protocol for deoxygenation of epoxides to alkenes via catalytic hydrogenation using gold.Electric Literature of 5455-98-1 And the article contains the following content:

The epoxidation of olefin as a strategy to protect carbon-carbon double bonds is a well-known procedure in organic synthesis, however the reverse reaction, deprotection/deoxygenation of epoxides is much less developed, despite its potential utility for the synthesis of substituted olefins. Here, we disclose a clean protocol for the selective deprotection of epoxides, by combining com. available organophosphorus ligands and gold nanoparticles (Au NP). Besides being successfully applied in the deoxygenation of epoxides, the discovered catalytic system also enables the selective reduction N-oxides and sulfoxides using mol. hydrogen as reductant. The Au NP catalyst combined with triethylphosphite P(OEt)3 is remarkably more reactive than solely Au NPs. The method is not only a complementary Au-catalyzed reductive reaction under mild conditions, but also an effective procedure for selective reductions of a wide range of valuable mols. that would be either synthetically inconvenient or even difficult to access by alternative synthetic protocols or by using classical transition metal catalysts. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to clean protocol deoxygenation epoxide alkene catalytic hydrogenation gold, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics