Category: 5455-98-1

On May 7, 2020, Koopmans, Carsten; Laemmerhold, Kai; Guertler, Christoph; Frick-Delaittre, Elena; Wolf, Aurel; Simon, Joachim; Wang, Min; Thiel, Daniel; Leitner, Walter published a patent.Related Products of 5455-98-1 The title of the patent was Production of thermoplastic polyoxazolidinone polymers and thermoplastic polyoxazolidinone. And the patent contained the following:

A process for producing thermoplastic polyoxazolidinone, comprising (i) reaction of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E) forming an intermediate compound (F) and (ii) reaction of a compound (G) with the intermediate (F) formed in step (i), where the bisepoxide compound (B) comprises isosorbide diglycidyl ether, where compound (D) is ≥1 compounds selected from monofunctional isocyanate and monofunctional epoxide, and where compound (G) is an alkylene oxide. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to thermoplastic polyoxazolidinone polymer, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 22, 2019, Sulake, Rohidas Shivaji; Mitra, Rangan; Kadam, Navnath Ambadas; Siyan, Rajinder Singh; Bhise, Nandu Baban; Singh, Girij Pal published a patent.HPLC of Formula: 5455-98-1 The title of the patent was Process for preparation of Neratinib intermediates. And the patent contained the following:

The present invention relates to a process for the preparation of Neratinib intermediates of compound I and compound II [X = halo]. The process involves reaction of compound III [LG = a leaving group] with acetonitrile to yield compound IV [LG is as defined above], reaction of IV with dimethylacetamide to yield compound V [LG is as defined above]; cyclizing V to yield compound VI; halogenation of VI to yield compound VII [X = halo] and reduction of VII to yield II [X = halo]; optionally II can be protected to yield compound VIII [X = halo]. E.g., a multi-step synthesis of VIII [X = Cl], starting from III [LG = OEt] (preparation given) and acetonitrile, was described. The process for the preparation of compound I which comprises the steps of: (a) reacting compound IX [R = alkyl] with alkyl acetate to give compound X [R = alkyl], (b) reducing X 7 in the presence of reducing agent to obtain a compound XI [R = alkyl], and (c) converting XI to compound I, was disclosed. For example, reacting IX [R = Et] with tert-Bu acetate followed by reducing X [R = Et] using NaBH4, and treating XI [R = Et] with Et3N, MsCl in DCM, and hydrolysis of resulting tert-Bu (E)-4-(dimethylamino)but-2-enoate in EtOAc-HCl solution afforded I.HCl. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1

The Article related to neratinib intermediate preparation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.HPLC of Formula: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Wang, Huihong; Cao, Fei; Gao, Weiwei; Wang, Xiaodong; Yang, Yuhang; Shi, Tao; Wang, Zhen published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Pd(II)-Catalyzed Annulation Reactions of Epoxides with Benzamides to Synthesize Isoquinolones. And the article contained the following:

Epoxides as alkylating reagents were unprecedentedly applied in Pd(II)-catalyzed C-H alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones I [R = 7-Me, 6-t-Bu, 6,8-di-OMe, etc.; R1 = Me, n-pentyl, Bn, etc.; R2 = OMe, OEt, OBn, etc.] rather than isochromans, which was accomplished through alerting the previously reported reaction mechanism by the addition of oxidant and TEA. Under these conditions, various isoquinolones were prepared with yields up to 92%. In addition, this methodol. was successfully employed in the total syntheses of rupreschstyril, siamine, and cassiarin A in an expedient fashion. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to isoquinolone preparation, epoxide benzamide ch alkylation oxidative annulation palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 7, 2022, Rostami, Ali; Ebrahimi, Amirhossein; Sakhaee, Nader; Golmohammadi, Farhad; Al-Harrasi, Ahmed published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Microwave-Assisted Electrostatically Enhanced Phenol-Catalyzed Synthesis of Oxazolidinones. And the article contained the following:

An electrostatically enhanced phenol is utilized as a straightforward, sustainable, and potent one-component organocatalyst for the atom-economic transformation of epoxides to oxazolidinones under microwave irradiation Integrating a pos. charged center into phenols over a modular one-step preparation gives rise to a bifunctional system with improved acidity and activity, competent in rapid assembly of epoxides and isocyanates under microwave irradiation in a short reaction time (20-60 min). A careful assessment of the efficacy of various pos. charged phenols and anilines and the impact of several factors, such as catalyst loading, temperature, and the kind of nucleophile, on catalytic reactivity were examined Under neat conditions, this one-component catalytic platform was exploited to prepare more than 40 examples of oxazolidinones from a variety of aryl- and alkyl-substituted epoxides and isocyanates within minutes, where up to 96% yield and high degree of selectivity were attained. DFT calculations to achieve reaction barriers for different catalytic routes were conducted to provide mechanistic understanding and corroborated the exptl. findings in which concurrent epoxide ring-opening and isocyanate incorporation were proposed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to oxazolidinone preparation microwave irradiation, epoxide isocyanate cycloaddition electrostatically enhanced phenol catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 3, 2020, Nishiyori, Ryuichi; Okuno, Ken; Shirakawa, Seiji published an article.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Triethylamine Hydroiodide as a Bifunctional Catalyst for the Solvent-Free Synthesis of 2-Oxazolidinones. And the article contained the following:

Among the wide variety of heterocycles, 2-oxazolidinones are recognized as some of the most important heterocyclic compounds in medicinal chem. Therefore, the development of a practical method for their synthesis would be an important development. Herein, we report an efficient method for the synthesis of 2-oxazolidinones under solvent-free conditions using triethylamine hydroiodide as a simple and effective bifunctional organocatalyst. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to epoxide isocyanate triethylamine hydroiodide cyclization catalyst, oxazolidinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 10, 2016, Bergman, Ylva Elisabet; Lessene, Romina; Ganame, Danny; Foitzik, Richard Charles; Morrow, Benjamin Joseph; Camerino, Michelle Ang; Walker, Scott Raymond; Lagiakos, H. Rachel; Feutrill, John; Stupple, Paul Anthony published a patent.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5 inhibitors. And the patent contained the following:

The invention relates to compounds of formula I, II and III as PRMT5-inhibitors; their preparation and use in the treatment of cancer and hemoglobinopathy. Compounds of formula I, II and III wherein n = 1 and 2; R is H and Me; R1 is halo and Me; R2a and R2b are independently F, H, Me and CH2OH; R2c and R2n are independently F, H, Me and CH2OH; R3a and R3b are independently H and Me; R4a is OH, NH2, CONH2 and CH2OH; R4b is H and Me; R5 is H and Me; A is (un)substituted Ph, (un)substituted naphthyl; and (un)substituted C5-12 heteroaryl, are claimed. Example compound IV was prepared by acylation of 1-amino-3-((2,3-dihydro-1H-inden-2-yl)amino)propan-2-ol with 4-chlorobenzoic acid. The invention compounds were evaluated for their PRMT5 inhibitory activity. From the assay, it was determined that example IV exhibited IC50 value of 0.792 μM. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to aminoindane aminotetrahydronaphthalene aminobenzocyclobutane preparation prmt5 inhibitor treatment cancer hemoglobinopathy, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 1, 2018, Peters, Edward Norman published a patent.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Epoxy hardener composition and associated forming method, uncured and cured epoxy resin compositions, and article. And the patent contained the following:

A hardener composition comprising: (A) 1 to 80% of a hydroxyl-diterminated poly(phenylene ether) having an intrinsic viscosity of 0.03 to 0.2 dL per g measured by Ubbelohde viscometer at 25° in chloroform; and (B) 20 to 99% of an anhydride having structure I wherein q is zero or 1, Ra is C1-C6-alkyl, and X is -CH2-, -(CH2)2-, -O-, or -S-; wherein the hardener composition exhibits a single glass transition temperature from -80 to 200°, wherein the single glass transition temperature has a value of -46 to 110°; and wherein the hardener composition comprises zero to 1% of solvents for the hydroxyl-diterminated poly(phenylene ether). Also disclosed are a method of forming the hardener composition, a curable epoxy composition incorporating the hardener composition, a cured composition formed from the curable epoxy composition, and an article that includes the cured composition The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to polyoxyphenylene anhydride epoxy hardener composition long pot life, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 14, 2011, Meyer, Jorg; Keul, Helmut; Moller, Martin published an article.COA of Formula: C11H9NO3 The title of the article was Poly(glycidyl amine) and Copolymers with Glycidol and Glycidyl Amine Repeating Units: Synthesis and Characterization. And the article contained the following:

The synthesis and characterization of poly(glycidol-co-glycidyl amine), poly(glycidol)-block-poly(glycidyl amine), and poly(glycidol) end-capped with a glycidyl amine unit is reported. Copolymerization of ethoxyethyl glycidyl ether with epichlorohydrin using tetraoctylammonium bromide/triisobutylaluminium as catalyst leads to statistical or block copolymers. Sequential addition of the monomers to the initiator leads to block copolymers while simultaneous copolymerization of the monomers results in statistical copolymers. The resulting polyethers with protected hydroxymethyl and chloromethyl side groups were converted in three steps to poly(epoxide)s with hydroxymethyl and aminomethyl side chains. These polymers have a high potential for the preparation of multifunctional polymers since amine and alc. groups can be addressed selectively by electrophiles. An intermediate in the synthesis of these functional poly(epoxide)s are polyethers with hydroxymethyl and azidomethyl side chains. The azide group of these copolymers was further functionalized via a click reaction with propargyl alc. proving the reactivity of the polymer bound azide group. Furthermore, preparation of poly(glycidol)s bearing a glycidyl amine end group is reported. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).COA of Formula: C11H9NO3

The Article related to polyglycidyl amine copolymer, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.COA of Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 22, 2018, Weber, Anna; Rangheard, Claudine; Kessler, Michael; Leitner, Walter; Guertler, Christoph; Koopmans, Carsten; Mueller, Thomas Ernst published a patent.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Process for the synthesis of polyoxazolidinone compounds. And the patent contained the following:

The invention relates to a method for the production of polyoxazolidinone compounds, comprising reacting an isocyanate compound (A) with an epoxide compound (B) in the presence of a catalyst (C), wherein the isocyanate compound (A) comprises a isocyanate compound (A1), comprising at least two isocyanate groups (I1 ≥ 2), preferred two isocyanate groups (I1 = 2), wherein the epoxide compound (B) comprises a epoxide compound (B1) and an epoxide compound (B2) different from the epoxide compound (B1), wherein the epoxide compound (B1) comprising at least two terminal epoxide groups (F1 ≥ 2), preferred two terminal epoxide groups (F1 = 2), linked together by a linking group (L1), and the epoxide compound (B2) comprising at least two terminal epoxide groups (F2 ≥ 2), preferred two terminal epoxide groups (F2 = 2), linked together by a linking group (L2 ), wherein the linking group (L2) comprises acyclic and covalent bonds to each other free of conjugated multiple bonds within the main chain, wherein the epoxide compound (B2) is present in the epoxide compounds B1 and B2 in an amount of ≥ 0.01 – < 10 mol%, preferred 1 - 9 mol%, more preferred 3 - 8 mol% based on the molar ratio the terminal epoxide groups in the epoxide compound (B1) and of the sum of the terminal epoxide groups in the epoxide compound (B1) and terminal epoxide groups in the epoxide compound (B2). Polyoxazolidinone compound, obtainable by the inventive method, is also claimed. Spun fiber, comprising a polyoxazolidinone compound, is also concerned. Textile, comprising a spun fiber, is also directed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to polyoxazolidinone compound synthesis catalyst, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 6, 2020, there was a patent about epoxides.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Method for the production of thermoplastic polyoxazolidinone polymers. And the patent contained the following:

The invention relates to a process for producing thermoplastic polyoxazolidinones, comprising copolymerization of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E), characterized in that, the bisepoxide compound (B) comprises isosorbide diglycidyl ether, the catalyst (C) is selected from the group consisting of alkali halogenides and earth alkali halogenides, and transition metal halogenides, the compound (D) is selected from the group consisting of monofunctional isocyanate, monofunctional epoxide, and wherein the process comprises: (a) placing the solvent (E) and the catalyst (C) in a reactor to provide a mixture; and (b) adding the diisocyanate compound (A), the bisepoxide compound (B), and the compound (D) to the mixture resulting from step (a). Thermoplastic polyoxazolidinone obtainable by the inventive process is also claimed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to thermoplastic polyoxazolidinone polymerization, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics