Category: 5455-98-1

Lukowska-Chojnacka, Edyta; Plenkiewicz, Jan published an article in 2011, the title of the article was Simple synthesis of 尾-acetoxy thiocyanates from oxiranes.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

A convenient and simple method for the preparation of previously unknown 尾-acetoxy thiocyanates by regioselective ring opening of the corresponding oxiranes with thiocyanate anion followed by acetylation is described. The shorter reaction times, better yields of the products, and easy workup are the advantages of this methodol. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to oxirane ammonium thiocyanate regioselective ring opening, acetoxy thiocyanate preparation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 19, 2020, Chen, Hui-Ting; Huang, Yangen; Qing, Feng-Ling; Xu, Xiu-Hua published an article.Computed Properties of 5455-98-1 The title of the article was Trifluoromethylthiolation of epoxides with AgSCF3: a new access to vinyl trifluoromethyl thioethers. And the article contained the following:

An unexpected synthesis of vinyl trifluoromethyl thioethers RCH=CHSCF3 [R = Ph, PhCO2CH2, indol-1-ylmethyl, etc.] from epoxides is described. Treatment of epoxides with AgSCF3 in the presence of n-Bu4NI and KI in toluene afforded various vinyl trifluoromethyl thioethers in moderate to good yields. The use of easily available substrates and tolerance of wide functional groups are the notable advantages of this protocol. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to vinyl trifluoromethyl thioether preparation diastereoselective, epoxide silver trifluoromethanethiolate trifluoromethylthiolation ring opening, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 20, 2015, Wang, Zhen; Kuninobu, Yoichiro; Kanai, Motomu published an article.Computed Properties of 5455-98-1 The title of the article was Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond Activation. And the article contained the following:

We achieved a palladium-catalyzed C-H activation/C-C coupling reaction between arenes with a pyridyl, aminoquinolinyl, imino, or amide directing group, and oxiranes. The reaction proceeded at room temperature without any additives and tolerated a wide variety of functional groups, and the products were obtained in good to excellent yields, even on gram scale. This is the first example of a transition-metal-catalyzed intermol. direct coupling reaction between a C-H bond of aromatic compounds and a carbon atom of oxiranes via C-H bond activation. By using N-methoxybenzamide as a substrate, we obtained 3-substituted isochroman-1-ones in one pot. The coupling reaction proceeded with stereoretention. Kinetic isotope effect experiments suggested that C-H bond activation is the rate-determining step. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to arene oxirane ring opening palladium catalyst, carbon hydrogen bond activation intermol direct coupling, hydroxyalkyl arene preparation, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 13, 2021, Kawamata, Yu; Hayashi, Kyohei; Carlson, Ethan; Shaji, Shobin; Waldmann, Dirk; Simmons, Bryan J.; Edwards, Jacob T.; Zapf, Christoph W.; Saito, Masato; Baran, Phil S. published an article.Synthetic Route of 5455-98-1 The title of the article was Chemoselective Electrosynthesis Using Rapid Alternating Polarity. And the article contained the following:

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochem. offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using d.c. (DC). In contrast, applying a.c. (AC) has been known to change reaction outcomes considerably on an anal. scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver elec. current-rapid alternating polarity (rAP)-enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chem. reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chem. topics such as the synthesis of PROTACs. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to electrochem chemoselective reduction ketone rapid alternating polarity, Heterocyclic Compounds (One Hetero Atom): General and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2014, Spear, Kerry L.; Campbell, Una published a patent.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of piperidinylindoline derivatives for use as nervous system agents. And the patent contained the following:

Title compounds I [R1 = halo, OH, CN, (un)substituted alkyl, aryl, etc.; R2 = H, halo, OH, alkyl, etc.; or R1 and R2 are taken together with the C atom to which they are attached to form an (un)substituted alkenyl, cycloalkyl or heterocyclyl; R3 = H, OH, halo, CN, alkyl, etc.; R5 = (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, etc.; each X independently = CH or N; Y = absent, O, NH, N-alkyl, or (un)substituted alkylene], and their pharmaceutically acceptable salts, are prepared and disclosed as nervous system agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in CAMP assays on CHO cells expressing the human NOP/MOP receptors (data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to piperidinylindoline preparation nervous system agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 13, 2021, Kawamata, Yu; Hayashi, Kyohei; Carlson, Ethan; Shaji, Shobin; Waldmann, Dirk; Simmons, Bryan J.; Edwards, Jacob T.; Zapf, Christoph W.; Saito, Masato; Baran, Phil S. published an article.Synthetic Route of 5455-98-1 The title of the article was Chemoselective Electrosynthesis Using Rapid Alternating Polarity. And the article contained the following:

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochem. offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using d.c. (DC). In contrast, applying a.c. (AC) has been known to change reaction outcomes considerably on an anal. scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver elec. current-rapid alternating polarity (rAP)-enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chem. reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chem. topics such as the synthesis of PROTACs. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to electrochem chemoselective reduction ketone rapid alternating polarity, Heterocyclic Compounds (One Hetero Atom): General and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2014, Spear, Kerry L.; Campbell, Una published a patent.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of piperidinylindoline derivatives for use as nervous system agents. And the patent contained the following:

Title compounds I [R1 = halo, OH, CN, (un)substituted alkyl, aryl, etc.; R2 = H, halo, OH, alkyl, etc.; or R1 and R2 are taken together with the C atom to which they are attached to form an (un)substituted alkenyl, cycloalkyl or heterocyclyl; R3 = H, OH, halo, CN, alkyl, etc.; R5 = (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, etc.; each X independently = CH or N; Y = absent, O, NH, N-alkyl, or (un)substituted alkylene], and their pharmaceutically acceptable salts, are prepared and disclosed as nervous system agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in CAMP assays on CHO cells expressing the human NOP/MOP receptors (data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to piperidinylindoline preparation nervous system agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 29, 2012, Uttam, Surana; Krishnan, Vaidehi; Ting, Anthony; Lim, Hong Hwa published a patent.HPLC of Formula: 5455-98-1 The title of the patent was Naphthalamide derivatives having antiproliferative activity. And the patent contained the following:

The invention relates to compounds for use in medicine. The compounds are of general formula (I) as disclosed herein and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers thereof, wherein X, X’ and X are independently O or S; Z is N or P; R3 is optional and is selected from the group consisting of optionally substituted C1-8 alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6 alkoxy, optionally substituted C1-6 thioalkyl, optionally substituted C5-10 aryl, optionally substituted C6-11 alkylaryl, optionally substituted C1-6 alkylamino, optionally substituted C1-6 alkylcarbonyl, optionally substituted C1-6 alkylsulfonamino, optionally substituted (C1-C6)alkylsulfinyl, optionally substituted C1-6 alkylcarbonylamino, optionally substituted hetero(C4-C10)aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; R1, R2, R4, R5, R6, R7, R8, R9, and R10 are independently selected from the group consisting of hydrogen, optionally substituted C1-8 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6 alkoxy, optionally substituted C1-6 thioalkyl, optionally substituted C5-10 aryl, optionally substituted C6-11 alkylaryl, optionally substituted C1-6 alkylamino, optionally substituted C1-6 alkylcarbonyl, optionally substituted C1-6 alkylsulfonamino, optionally substituted (C1-C6)alkylsulfinyl, optionally substituted C1-6 alkylcarbonylamino, optionall. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1

The Article related to naphthalamide derivative antiproliferative agent, antitumor agent naphthalamide derivative, antifungal agent naphthalamide derivative, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.HPLC of Formula: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ali, Mohammad; Zarchi, Karimi; Tarabsaz, Ali published an article in 2015, the title of the article was Ring Opening of Epoxides by Using Cross-Linked Poly(4-Vinylpyridine)-Supported Thiocyanate in the Presence of Polymer-Supported Sulfuric Acid Under Solvent-Free Conditions.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

Cross-linked poly(4-vinylpyridine)-supported thiocyanate ion, [P4-VP]SCN, is introduced as recyclable polymeric reagent for the efficient and regioselective conversion of epoxides to thiocyanohydrins in the presence of cross-linked poly(4-vinylpyridine)-supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The ring-opening reaction of epoxides take place very fast under solvent-free conditions and the regioselective thiocyanohydrins are prepared in high yields at 65°C. The present method offers advantages such as short reaction time, simple reaction work-up, and the polymeric reagents can be regenerated and reused several times without significant loss of their activity. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to epoxide ring opening polymer supported reagent solvent free, Plastics Manufacture and Processing: Chemical Properties Of Resins and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2014, Sugawara, Yasuhisa; Sakata, Koji; Tomioka, Yasuhiro; Demizu, Hiroyuki; Satoh, Hiroki published a patent.Formula: C11H9NO3 The title of the patent was Solid electrolytic capacitor. And the patent contained the following:

Provided is a solid electrolytic capacitor having a low initial equivalent series resistance (ESR) in which the ESR increase with time can be suppressed. It is a solid electrolytic capacitor, including an electroconductive polymer layer, a graphite layer on the electroconductive polymer layer, and a silver layer on the graphite layer, wherein the electroconductive polymer layer and the graphite layer, and/or, the graphite layer and the silver layer are bonded by a chem. bond. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to capacitor electrolytic solid low equivalent series resistance, Electric Phenomena: Capacitors, Dielectrics, Insulators, Electrets and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics