Category: 54468-86-9

Some common heterocyclic compound, 54468-86-9, name is 2-Amino-N,N-dimethylbenzenesulfonamide, molecular formula is C8H12N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 54468-86-9

General procedure: To a solution of 2-(isopropylsulfonyl)aniline (3.0 g,15.1 mmol) in DMF (80 mL) was added sodium hydride (1.2 g,30.1 mmol, 60% in mineral oil) at 0 C. After stirring for 30 min,2,4,5-trichloropyrimidine was added to the reaction mixture followedby warming the mixture to room temperature. After stirringfor 2 h, the reaction mixture was quenched with ice and dilutedwith excess water. The precipitate was filtered and the solid wasdried by blowing nitrogen gas to obtain 3c as an off-white solid(3.75 g, 72%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 54468-86-9, its application will become more common.

Reference:
Article; Jang, Jaebong; Son, Jung Beom; To, Ciric; Bahcall, Magda; Kim, So Young; Kang, Seock Yong; Mushajiang, Mierzhati; Lee, Younho; Jaenne, Pasi A.; Choi, Hwan Geun; Gray, Nathanael S.; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 497 – 510;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

54468-86-9, name is 2-Amino-N,N-dimethylbenzenesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-Amino-N,N-dimethylbenzenesulfonamide

To a screw cap vial was added 2-amino-(N, N-dimethyl) phenylsulphonamide (34.9mg, 0. [17MMOL),] DPT (40.5mg, 0. [17MMOL)] and [CH2CI2] (3mL). The resultant bright orange solution was stirred at room temperature for 1 hour and forty-five minutes. At this time, DPT was again added (21. Omg, 0. [09MMOL)] and after one hour of stirring, a TLC was taken showing the reaction to be 50% complete. DPT was again added (21. Omg, 0. [09MMOL)] and the reaction was heated to [50C] for one hour. The reaction mixture was put through an SPE tube [(CH2CI2)] to yield the title compound as a yellow oil (34. [1 MG,] 98%).

The synthetic route of 54468-86-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NPS ALLELIX CORP.; WO2004/22534; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54468-86-9, name is 2-Amino-N,N-dimethylbenzenesulfonamide, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks

Compound c18-3 (1 g, 5 mmol) was placed in a 100 mL three-necked flask and added to N,N-dimethylformamide (20 mL).The ice salt bath was below 0 C, then sodium hydride (0.4 g, 10 mmol) was added and stirred for 15 minutes.Then a solution of compound b2 (0.86 mL, 10 mmol) in N,N-dimethylformamide was added and stirred at room temperature overnight.10mL of water was added, extracted with ethyl acetate, the organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate,Concentration through the column gave 0.47 g of a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 54468-86-9, name is 2-Amino-N,N-dimethylbenzenesulfonamide, molecular formula is C8H12N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H12N2O2S

General procedure: To a solution of 2-(isopropylsulfonyl)aniline (3.0 g,15.1 mmol) in DMF (80 mL) was added sodium hydride (1.2 g,30.1 mmol, 60% in mineral oil) at 0 C. After stirring for 30 min,2,4,5-trichloropyrimidine was added to the reaction mixture followedby warming the mixture to room temperature. After stirringfor 2 h, the reaction mixture was quenched with ice and dilutedwith excess water. The precipitate was filtered and the solid wasdried by blowing nitrogen gas to obtain 3c as an off-white solid(3.75 g, 72%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 54468-86-9, its application will become more common.

Reference:
Article; Jang, Jaebong; Son, Jung Beom; To, Ciric; Bahcall, Magda; Kim, So Young; Kang, Seock Yong; Mushajiang, Mierzhati; Lee, Younho; Jaenne, Pasi A.; Choi, Hwan Geun; Gray, Nathanael S.; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 497 – 510;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics