Category: 5339-69-5

Gajda, Tadeusz et al. published their research in Synthesis in 1981 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 5339-69-5

Phase-transfer-catalyzed N-alkylation of carboxamides and sulfonamides was written by Gajda, Tadeusz;Zwierzak, Andrzej. And the article was included in Synthesis in 1981.Application of 5339-69-5 This article mentions the following:

The conversion of PhCONH2 to PhCONHR and PhCONR2 (R = Et, Pr, Bu, Me2CHCH2, PhCH2, Me2CH) was catalyzed by Bu4N+ HSO4– (I). A mixture of PhCONH2, EtBr, NaOH, and I in C6H6 was refluxed to give PhCONHEt. Similarly prepared were EtCONHR1 (R1 = Et, Pr, Bu), PhSO2N(R2)2 (R2 = Me, Et, Bu, PhCH2, Me2CH), and MeSO2N(R3)2 (R3 = Et, PhCH2, Me2CH). In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Application of 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ohrui, Satoshi et al. published their research in Bunseki Kagaku in 1991 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Name: N-Isopropylbenzenesulfonamide

Determination of primary amines by benzenesulfonylation/GC with flame photometric detection was written by Ohrui, Satoshi;Kataoka, Hiroyuki;Miyamoto, Yoshiaki;Ohtsuka, Kimiyo Takeda;Nakita, Masami. And the article was included in Bunseki Kagaku in 1991.Name: N-Isopropylbenzenesulfonamide This article mentions the following:

A selective and sensitive GC (gas chromatog.) method is described for the determination of primary amines. After benzenesulfonylation of by the Hinsberg reaction, primary amines were completely separated from secondary amines by extraction with hexane in 50% KOH-22.5% MeOH solution Benzenesulfonyl derivatives of primary amines in acidic aqueous layer were extracted by Et2O and determined by GC with flame photometric detection (FPD-GC) using a DB-1 capillary column. The FPD-GC calibration curves of amines were linear in the range of 20-1000 ng for the derivatives and the detection limits were about 10-100 pg as injection amounts This was >20 times more sensitive than the results obtained by GC with flame ionization detection. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Name: N-Isopropylbenzenesulfonamide).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Name: N-Isopropylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Aiyun et al. published their research in Organic Letters in 2021 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of N-Isopropylbenzenesulfonamide

Structurally Diverse Synthesis of Five-, Six- and Seven-membered Benzosultams through Electrochemical Cyclization was written by Liu, Aiyun;Guo, Tiantian;Zhang, Shuangshuang;Yang, Han;Zhang, Qi;Chai, Yonghai;Zhang, Shengyong. And the article was included in Organic Letters in 2021.Quality Control of N-Isopropylbenzenesulfonamide This article mentions the following:

A metal- and oxidant-free approach to structurally diverse synthesis of benzosultams I (R1 = i-Pr, t-Bu, Me; R2 = H, 8-Ph, 7,9-di-Me, 9-F, etc.), II (R3 = H, Me) and III (R4 = H, 4-Cl, 5-Me, 6-Me, etc.) from aryl sulfonamides R1C6H3S(O)2R5 (R5 = H, 4-Me, 3-Cl, 6-Cl, etc.) through an electrochem. cyclization was developed. By varying the ortho-substituent on aryl sulfonamides, five-, six-, and seven-membered benzosultams I, II and III were efficiently assembled in an atom- and resource-economic manner. The generality of the process is demonstrated by the formation of five to seven-membered cyclic products from substrates bearing substituents R1C6H3S(O)2R5 with different electronic effects and steric hindrance. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Quality Control of N-Isopropylbenzenesulfonamide).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of N-Isopropylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lai, Zhencheng et al. published their research in Organic Letters in 2020 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C9H13NO2S

Redox Cyclization of Amides and Sulfonamides with Nitrous Oxide for Direct Synthesis of Heterocycles was written by Lai, Zhencheng;Wang, Chaorong;Li, Jiaming;Cui, Sunliang. And the article was included in Organic Letters in 2020.Electric Literature of C9H13NO2S This article mentions the following:

A redox cyclization of amides R1C(O)NHR2 (R1 = C6H5, 1-naphthyl, 5-methylthiophen-2-yl, etc.; R2 = Me, t-Bu, cyclopropyl, etc.) and sulfonamides 4-R3C6H4S(O)2NHR4 (R3 = H, Me, t-Bu, Ph, OMe, Cl; R4 = Me, t-Bu, cyclopropyl, etc.) with nitrous oxide (N2O) for the direct synthesis of heterocycles, e.g., I has been described. Various amides and sulfonamides could undergo directed ortho metalation (DoM) by treatment with BuLi, and the lithium intermediate could be trapped by N2O gas to achieve redox cyclization. N2O serves as an N-atom donor to mediate the intramol. coupling of lithium species toward heterocycle formation with free external oxidant. This protocol offers a direct synthesis of heterocycles with features of readily available starting materials, simple operation, and a broad substrate scope. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Electric Literature of C9H13NO2S).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C9H13NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xu, Liang et al. published their research in Synlett in 2004 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: N-Isopropylbenzenesulfonamide

Novel N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides with periodic acid catalyzed by chromium(III) acetate hydroxide was written by Xu, Liang;Zhang, Suhong;Trudell, Mark L.. And the article was included in Synlett in 2004.Name: N-Isopropylbenzenesulfonamide This article mentions the following:

Chromium(III) acetate hydroxide was found to be an efficient catalyst for N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides to furnish sulfonamides in good to excellent yields with periodic acid in acetonitrile at room temperature In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Name: N-Isopropylbenzenesulfonamide).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: N-Isopropylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Krasnogorskaya, N. N. et al. published their research in Zhurnal Prikladnoi Spektroskopii in 1989 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Related Products of 5339-69-5

Study of self-association of benzenesulfonamides in carbon tetrachloride by the NMR method was written by Krasnogorskaya, N. N.;Shcherbakova, E. S.;Gur’yanova, E. N.;Gabdikeeva, A. R.;Poletaeva, M. G.. And the article was included in Zhurnal Prikladnoi Spektroskopii in 1989.Related Products of 5339-69-5 This article mentions the following:

Self-association of title compounds PhSO2NHR (R = Bu, Me2CH) in CCl4 was studied by 1H NMR. It occurs via intermol. NH···O hydrogen bonds. The degree of self-association increases with concentration and decreases with a rise in temperature Thermodn. parameters for associated mols. were determined In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Related Products of 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Related Products of 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Dinghai et al. published their research in Journal of the American Chemical Society in 2017 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 5339-69-5

Asymmetric Copper-Catalyzed Intermolecular Aminoarylation of Styrenes: Efficient Access to Optical 2,2-Diarylethylamines was written by Wang, Dinghai;Wu, Lianqian;Wang, Fei;Wan, Xiaolong;Chen, Pinhong;Lin, Zhenyang;Liu, Guosheng. And the article was included in Journal of the American Chemical Society in 2017.Related Products of 5339-69-5 This article mentions the following:

We have developed a copper-catalyzed enantioselective intermol. aminoarylation of alkenes using a novel N-fluoro-N-alkylsulfonamide as the amine reagent, which could react with the Cu(I) catalyst to release a related amino radical. After addition to styrene, the generated benzylic radical could couple with a chiral L*CuIIAr complex to achieve enantioselective arylation. Various optical 2,2-diarylethylamines were efficiently synthesized from simple styrenes with high enantioselectivity, and these products can serve as valuable synthons toward bioactive mols.’ synthesis. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Related Products of 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Badawi, A. M. et al. published their research in Delta Journal of Science in 1991 | CAS: 5339-69-5

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of N-Isopropylbenzenesulfonamide

New metal compounds of sulfonamides as fungicides against plant pathogenic fungi was written by Badawi, A. M.;Salama, M. A.;Mahmoud, M. B.. And the article was included in Delta Journal of Science in 1991.Application In Synthesis of N-Isopropylbenzenesulfonamide This article mentions the following:

Copper, zinc, tin, cobalt and mercury complexes of N-iso-Pr benzenesulfonamide were synthesized and tested as fungicides for control of some plant pathogenic fungi. Structure-activity relationships were discussed. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Application In Synthesis of N-Isopropylbenzenesulfonamide).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application In Synthesis of N-Isopropylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics