Category: 5338-44-3

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5338-44-3 as follows. Application In Synthesis of Ethyl 4-acetamidobenzoate

General procedure: Phosphorus oxychloride, 4.8 mL (7.7 g, 50 mmol) and 1.3 g (20 mmol) of NaN3 were added to a vigorously stirred solution of amide 2a-2e, 6, 11a-11e, 15, 19a, 19b, 22, 25a, 25b, or 27 (10 mmol) in 20 mL of acetonitrile. The mixture was refulxed for 5-7 h, acetonitrile was evaporated, the residue was dissolved in water with ice, and the solution was neutralized with saturated soda solution. The precipitate that formed was filtered off. Liquid tetrazoles were extracted with methylene chloride, and the solvent was evaporated in a vacuum.

According to the analysis of related databases, 5338-44-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Obushak, M. D.; Pokhodylo, N. T.; Shyyka, O. Ya.; Russian Journal of Organic Chemistry; vol. 56; 5; (2020); p. 802 – 812; Zh. Org. Khim.; vol. 56; 5; (2020); p. 753 – 765,13;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

These common heterocyclic compound, 5338-44-3, name is Ethyl 4-acetamidobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H13NO3

General procedure: To a solution of amidoxime 1 (2 mmol) and ester 2 (3 mmol) inDMSO (2 mL) 120 mg (3 mmol) powdered NaOH was rapidlyadded.The reaction mixture was stirred at room temperature for therequired time (TLC or precipitation of the product). The reactionmixture was diluted with cold water (30e50 mL). The resultingprecipitate was ltered off, washed with water (30 mL) and dried inair at 50 C.

The synthetic route of Ethyl 4-acetamidobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Baykov, Sergey; Sharonova, Tatyana; Shetnev, Anton; Rozhkov, Sergey; Kalinin, Stanislav; Smirnov, Alexey V.; Tetrahedron; vol. 73; 7; (2017); p. 945 – 951;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics