Category: 530-40-5

Rao, G. Venkateswara published the artcilePreferential reactivity of pyridylmagnesium chloride with N,N-dialkyl arylamides over carbonitriles: synthesis of 2-(aroyl) pyridines, COA of Formula: C10H14N2O, the publication is Synthetic Communications (2009), 39(10), 1835-1846, database is CAplus.

Reaction of 2-pyridylmagnesium chlorides with N,N-dialkyl arylamides afford exclusively 2-(aroyl)pyridines in high yields and purity without the formation of any tertiary alc. This method employs easily available raw materials and avoids the use of hazardous lithium reagents and cryogenic conditions. Further, preferential reactivity of this Grignard reagent with N,N-dialkyl arylamides over its carbonitrile counterparts offers a variety of 2-(aroyl)pyridines including the ones containing carbonitrile groups on the aryl ring.

Synthetic Communications published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, COA of Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yavorskii, N. P. published the artcileComplexes of cadmium thiocyanate and bromide with nitrogen-containing drugs, Formula: C10H14N2O, the publication is Farmatsiya (Moscow, Russian Federation) (1970), 19(2), 49-53, database is CAplus.

A study of complex formation of Cd thiocyanate (I) and CdBr2 with N-containing bases is presented. Piperazine, isoniazid, and amidopyridine form complexes XCd(CNS)2 (X = base) with I, with hexamethylenetetramine X.2Cd(CNS)2, and with nicotine X2.Cd(CNS)2.2HCNS. With CdBr2, complexes of the type X.CdBr2.2HBr are obtained with N-containing bases. The formed complexes with I and with CdBr2 are poorly H2O soluble The reaction sensitivity for I ranges from 5 to 40,000 γ/ml, and for CdBr2 from 10 to 30,000 γ/ml of the investigated bases. Complexes of preparations used in the form of salts have a common composition

Farmatsiya (Moscow, Russian Federation) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C30H24BrCuN2P, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Marchlewski, L. published the artcileAbsorption of ultra-violet light by some organic substances. XXIX, Formula: C10H14N2O, the publication is Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques (1933), 95-8, database is CAplus.

The α, β and γ isomers of C₅H₄NCONEt₂ in aqueous solution give similar absorption spectra in the ultra-violet, but the spectra are quite different from that of C₅H₅N (cf. C. A. 23, 5405). Each shows one absorption band with maximum and min. as follows: α isomer, maximum at 2625 A. U., min. at 2455 A. U.; β isomer, maximum at 2615 A. U., min. at 2475 A. U.; γ isomer, maximum at 2580 A. U., min. at 2430 A. U.

Bulletin International de l’Academie Polonaise des Sciences et des Lettres, Classe des Sciences Mathematiques et Naturelles, Serie A: Sciences Mathematiques published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhao, Yigang published the artcileC-H Activation by Amide Chelation Control: Ruthenium-Catalyzed Direct Synthesis of 2-Aryl-3-furanamides, Formula: C10H14N2O, the publication is Advanced Synthesis & Catalysis (2014), 356(7), 1527-1532, database is CAplus.

A new, catalytic methodol. for the synthesis of heterobiaryls by the ruthenium-catalyzed C-H activation/cross-coupling of heterocyclic amides with 2-aryl-1,3,2-dioxaborinanes is surveyed. From this survey, the highly regioselective reaction of furan-3-carboxamide to give 2-aryl-3-furanamides is optimized and generalized in scope with respect to the 2-aryl-1,3,2-dioxaborinane partners. E.g., in presence of RuH₂(CO)(PPh₃)₃ in toluene, reaction of N,N-diethylfuran-3-carboxamide with 2-aryl-1,3,2-dioxaborinane derivative (I) gave 92% heterobiaryl (II). Established thereby is a one-step synthetic method which may supercede the broadly applied two-step directed ortho metalation (DoM)-cross coupling reaction involving cryogenic and strong base conditions and which has potential for further ortho and remote metalation chem.

Advanced Synthesis & Catalysis published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C11H10N4, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Watanabe, M. published the artcileTandem directed metalation reactions. Short syntheses of polycyclic aromatic hydrocarbons and ellipticine alkaloids, COA of Formula: C10H14N2O, the publication is Journal of the American Chemical Society (1980), 102(4), 1457-60, database is CAplus.

Starting with N,N-diethylbenzamides and aromatic aldehydes and proceeding via ortho lithiated intermediates, a one-pot synthesis of anthraquinones, e.g. I and II, was achieved. The scope and limitations of this tandem metalation sequence was explored for a variety of aromatic and heteroaromatic amides and aldehydes. The use of this reaction for the short syntheses of carcinogenic polycyclic aromatic hydrocarbons and antitumor ellipticine alkaloids, e.g. III was demonstrated.

Journal of the American Chemical Society published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C12H25Br, COA of Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sattler, Hans J. published the artcileNMR spectroscopy of heterocycles, 2. Ring alkylated and isomeric nicetamide derivatives, COA of Formula: C10H14N2O, the publication is Archiv der Pharmazie (Weinheim, Germany) (1976), 309(3), 222-8, database is CAplus and MEDLINE.

Barriers to amide group rotation (ΔG*) in I (R = H, Me; R1 = H, Me; R2 = H, CONEt2; R3 = H, Me), II, and III (R = H, Me, CONEt2) were determined via 1H NMR spectral data. The ΔG* values ranged from 14.9 to 17.5 kcal/mole.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, COA of Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sattler, H. J. published the artcileStructure-activity relations in analeptics of nicethamide type. I. Diethylamides of homologs and vinylogs of nicotinic and isonicotinic acids, Computed Properties of 530-40-5, the publication is Arzneimittel-Forschung (1974), 24(5), 743-6, database is CAplus and MEDLINE.

The diethylamides I and II (bond in 3 or 4 position, Z = bond, CH2, CH2CH2, or CH:CH) were prepared and showed respiratory analeptic activities in rabbits. I were prepared in 68-76% yield by reaction of the corresponding pyridinecarboxylic acid with ClCO2Et and Et2NH. II were prepared by reaction of acetylpyridines with MeONa and HCO2Et and subsequently with Et2NH.

Arzneimittel-Forschung published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Computed Properties of 530-40-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lieber, Charles M. published the artcileKinetic studies of ligand substitution rates for the Ru(NH₃)₅(H₂O)²⁺ ion in Nafion films, Synthetic Route of 530-40-5, the publication is Journal of the American Chemical Society (1986), 108(20), 6103-8, database is CAplus.

Substitution rates were measured for reaction of a number of pyridines with the Nafion-bound Ru(NH₃)₅(H₂O)²⁺ complex. Reaction activities were determined by electrochem. techniques, which also allow for determination of site thermodn. and heterogeneity during the course of the reaction. Diffusion-coefficient effects were investigated by variation in polymer film thickness, and partition coefficients were determined under equilibrium conditions by optical absorbance techniques. The partition-coefficient corrected rate law is 1st order in Nafion-bound [Ru^II] and first order in ligand concentration in the polymer phase. The partition-coefficient corrected bimol. rate constants for a variety of pyridine ligands vary by a factor of 5, which contrasts with the relatively constant substitution rates observed in aqueous solution Also, sterically hindered ligands, such as 2-pyropylpyridine, have surprisingly high substitution rate constants on the Nafion-bound Ru^II ion. These rate data indicate that pronounced mol. reactivity changes can occur upon electrode modification and have implications with respect to the design of chem. modified electrodes for use in electrocatalysis.

Journal of the American Chemical Society published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Synthetic Route of 530-40-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Neumann, Wilhelm P. published the artcileSyntheses with the compounds R₃M-Hg-MR₃. Part XVII. N-Silyl and N-germylpyridinyl radicals and their stabilization reactions, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Chemische Berichte (1979), 112(3), 936-49, database is CAplus.

The reactions of pyridines functionally substituted in the 2-, 3-, or 4-position with (Me₃Si)₂Hg (I) or (Me₃Ge)₂Hg are described. With I the initially formed N-silylpyridinyls yield mostly N,ω-bis(silyl) derivatives (e.g., II from N,N-diethyl-4-pyridinecarboxamide) and tetrahydro-4,4′- or -2,2′-bipyridines, depending on mesomeric and steric conditions. Pyridine 2- or 3-acyl derivatives yield O-silylated hydropyridoins (Me₃SiOCRR¹)₂ (R = 2-pyridyl, R¹ = H or Me; R = 3-pyridyl, R¹ = Ph). 2-Cyanopyridine forms a persistent N-silylpyridinyl. N-Germylpyridinyls are formed only for pyridines of low electron d. or in cases involving strong mesomeric stabilization. ESR data are given for most of the radicals.

Chemische Berichte published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kim, Inwon published the artcileFunctionalization of Pyridinium Derivatives with 1,4-Dihydropyridines Enabled by Photoinduced Charge Transfer, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Organic Letters (2020), 22(21), 8730-8734, database is CAplus and MEDLINE.

By exploiting electron donor-acceptor (EDA) complexes between 1,4-dihydropyridines and N-amidopyridinium salts under visible light irradiation, we discovered that photoinduced intermol. charge transfer induces a single-electron transfer event without requiring a photocatalyst for the facile functionalization of pyridines. The generality of this method is amenable to various types of 1,4-dihydropyridine radical precursors to generate structurally different radicals such as alkyl, acyl, and carbamoyl radicals, ultimately providing facile access to synthetically valuable C4-functionalized pyridines. A broad range of functional groups are well accommodated under mild and metal-free conditions, and the synthetic utility of the present method is showcased by the late-stage functionalization of a variety of biol. relevant pyridine-based compounds, pharmaceuticals, and peptide feedstocks.

Organic Letters published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics